Antiviral Activity of Polyporoid Mushrooms (Higher Basidiomycetes) from Altai Mountains (Russia)

Teplyakova, T. V.; Psurtseva, Nadezhda V.; Косогова, Т. А.; Мазуркова, Н. А.; Khanin, Viacheslav A; Vlasenko, V. A.

doi:10.1615/intjmedmushr.v14.i1.40

Cited by 60 publications

(27 citation statements)

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“…A previous study demonstrated that polysaccharides possessed potent anti-inflammatory activity in rats with burn injuries [26]. As mentioned above, an extract of T. versicolor, containing a polysaccharide known as PSK [16] displays some potent biological activities, including immune activity [13], antiviral activity [14], and antimetastatic activity [27]. However the precise chemical source of this mushroom's antioxidant activity is not known.…”

Section: Anti-inflammatory Activity Of Samplesmentioning

confidence: 99%

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Antioxidant/Anti-Inflammatory Activities and Chemical Composition of Extracts from the Mushroom Trametes Versicolor

Kamiyama¹,

Shibamoto

Horiuchi³

et al. 2013

IJNFS

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Abstract:The mushroom, Trametes versicolor is commonly used as a traditional Chinese medicine and is known to exhibit various biological activities. However, its antioxidant activity has remained unknown. In the present study, various extracts obtained from the Trametes versicolor mushroom were examined for antioxidant and anti-inflammatory activities. Among the extracts obtained with Soxhlet extraction, the extract from acetone exhibited the highest antioxidant activity (50.9%), followed by the extracts from methanol (33.9%), n-hexane (29.5%), and chloroform (15.2%) at the level of 500 µg/mL. This acetone fraction displayed a dose-dependent anti-inflammatory activity or lipoxygenase inhibitory activity by 76.4% at 500 µg/mL, 55.6% at 200 µg/mL, and 37.0% at 100 µg/mL. Among a total of 76 compounds identified in this acetone extract, hexadecanoic acid was the largest component (18.11 mg/kg), followed by 5-hydroxy-2-pentanone (17.33 mg/kg), lactic acid (3.25 mg/kg), and acetic acid (3.21 mg/kg). The following possible principles of antioxidant activity were identified: furfural (1.48 mg/kg), γ-butyrolactone (0.51 mg/kg), furfuryl alcohol (0.49 mg/kg), 2-methoxy-4-vinylphenol (0.49 mg/kg), and 2,6-dimetoxy-4-vinylphenol (0.33 mg/kg), and benzaldehyde (0.15 mg/kg).

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Section: Anti-inflammatory Activity Of Samplesmentioning

confidence: 99%

“…Trametes versicolor is a Chinese medicinal mushroom known to possess a wide range of biological activities including immune-enhancing activity [12], antitumor [13], and antiviral effects [14]. A prophylactic bioactive of the mushroom extract, known as PSK, has been demonstrated to be effective against carcinogenesis [15].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant/Anti-Inflammatory Activities and Chemical Composition of Extracts from the Mushroom Trametes Versicolor

Kamiyama¹,

Shibamoto

Horiuchi³

et al. 2013

IJNFS

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“…This fungus is a gilled polyphore, a type of mushroom that grows on the trunks/bark of trees throughout North America [18]. Interestingly, it has been studied and found to exhibit anticancer, antimicrobial, antiviral, antioxidant, and anti-inflammatory properties [19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Fungal Keratitis Secondary to Trametes betulina: A Case Report and Review of Literature

et al. 2017

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“…There have been different studies on the various medicinal uses of Lenzites spp. antimicrobials 8,9 , anti-viral 10 , and immunosuppresser 11 . Phytochemical analysis of compounds presents in Lenzites spp.…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer property of Lenzites betulina (L) Fr. on cervical cancer cell lines and its anti-tumor effect on HeLa-implanted mice

Sanyal

Ghosh

2019

Preprint

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In global scenario cervical cancer is increasing. New drugs from natural compounds are in search. Mushrooms are now recognized as miniature pharmaceutical factories producing hundreds of novel constituents. We have taken ethanolic extract Lenzities betulina (LBE) wild mushroom for evaluation of its as anti-cancer property against cervical cancer cell lines e.g. HeLa, CaSki and SiHa and anti tumor activity against HeLa implanted tumor on mice. The extraction was done by dip and stirring method in 90% ethanol for 72 h. For evaluation of anti-cervical cancer, several assays were performed such as MTT assay, cell morphology by phase contrast microscope and F-action polymerization by Laser scanning confocal microscope and nuclear morphology DAPI staining under inverted fluorescence microscope, MMP, ROS, cell cycle, autophagy and stem cell population by flow cytometry and DNA laddering were done. Western blotting was done for protein expression. To evaluate anti-metastatic activity, anti-cologenic assay and wound healing assay were adopted. For chemo-analysis of the LBE, GC-MS was done. The results from Cytotoxicity assay showed that at highest dose of LBE (1000 µg/ml) after 24 h, percentage of cell inhibitions were 85.13 %, 77.13 % and 47.70 % against HeLa , CaSki and SiHa respectively and the calculated IC 50 values were 492.52 ± 2.6 µg/ml, 612.22 ± 4.2 µg/ml, and 1210.30 ± 6.4 µg/ml respectively . Depending upon the cytotoxicity screening, HeLa cell line was considered for the further studies. Cell morphology study exhibited that LBE treated HeLa cells became round from normal spindle shape. DAPI staining showed that LBE treated nucleus became condensed and fragmented. DNA fragmentation at 230 and 300 base pair zone from agarose gel assay was observed. LBE induced ROS generation and reduced MMP. It up regulated the expression of apoptotic genes and p53 while down regulated Bcl2, pro-caspase 3 and pro caspase-9 gene. Cell cycle was arrested at G2/M checkpoint. Autophagic induction was exhibited by vacuole formation in treated cells. CSC population of treated cells was reduced and F-actin polymerization was observed in treated cells. In addition, LBE suppressed metastatic nature by inhibition of cell migration and colonization. The inhibition of growth of the tumors in HeLa cell-implanted mice showed that treatment with 50 mg LBE/kg of body weight of mice led to a marked reduction in the volume (93.22 ± 9.2 %) and weight (90.42 ±9.55 %) of the tumors. The GC-MS profile of LBE shows that out of 69 compounds, 9, 12-Octadecadienoic acid (Z, Z) and 8, (3.beta22E) are in a significantly higher proportion with the percentage peak area 22.13 and 19.72 respectively. Library search for bioactivity showed that these compounds are anti-cancerous and interestingly 4'-Hydroxy-6methoxyaurone binding with P-glycoprotein inhibits the cancer cells to become drug resistant. In conclusion, LBE is very prominent anti-cervical cancer having a lot of anti-cancerous compounds which are probably acting synergistically. This report of anti-ce...

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Antiviral Activity of Polyporoid Mushrooms (Higher Basidiomycetes) from Altai Mountains (Russia)

Cited by 60 publications

References 0 publications

Antioxidant/Anti-Inflammatory Activities and Chemical Composition of Extracts from the Mushroom Trametes Versicolor

Antioxidant/Anti-Inflammatory Activities and Chemical Composition of Extracts from the Mushroom Trametes Versicolor

Fungal Keratitis Secondary to Trametes betulina: A Case Report and Review of Literature

Anti-cancer property of Lenzites betulina (L) Fr. on cervical cancer cell lines and its anti-tumor effect on HeLa-implanted mice

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