Antiviral activity against type A influenza virus of birds A/chicken/Kurgan/05/2005 (H5N1) and humans A/Aichi/2/68 (H3N2) was investigated for aqueous extracts from mycelium of 11 basidial fungi species collected in the Altai Mountains (Altai Republic, Russia). The most perspective strains for producing antiviral medicines are studied strains Daedaleopsis confragosa, Datronia mollis, Ischnoderma benzoinum, Trametes gibbosa, T. versicolor, Laricifomes officinalis, and Lenzites betulina.
This review presents data on the studied antiviral activities of Agaricomycetes mushrooms against the herpes, West Nile, influenza, human immunodeficiency, and hepatitis viruses, as well as orthopoxviruses, including the variola virus. Polysaccharides and other compounds (e.g., proteins, glycoproteins, terpenoids, melanins, nucleosides) exhibit antiviral activity against many viruses that are pathogenic in humans. Effective strains isolated from wild mushrooms in culture represent promising objects for the development of biotechnological drugs, including ones possessing antiviral activity. The data on antitumor and antiviral activities of compounds from the same mushroom species indicate the correlation of these properties. With regard to this connection, preparations of Basidiomycetes may have prophylactic value in preventing cancers with a viral etiology.
The antiviral properties of water extracts from pharmaceutical raw materials of the chaga mushroom, Inonotus obliquus, were studied against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). All studies with infectious materials were carried out in an isolated virological laboratory of the State Research Center of Virology and Biotechnology Vector of Rospotrebnadzor, which has a sanitary and epidemiological conclusion for the right to work with pathogenic biological agents of I-II pathogenicity groups. Antiviral activity was determined by the ability of I. obliquus water extracts to inhibit the replication of SARS-CoV-2 (nCoV/Victoria /1/2020 strain) in Vero E6 and Vero cell cultures. The results of these studies showed that water extracts of I. obliquus are characterized by low toxicity in Vero and Vero E6 cell cultures and have antiviral activity against SARS-CoV-2. The 50% inhibitory concentration ranged from 0.75 to 11.6 μg/mL. A patent for the invention was received (Patent RU,
Basidial fungi have long been known as sources of antitumor compounds such as polysaccharides. Studies conducted by scientists from different countries demonstrate that polysaccharides and other fungal compounds (proteins, glycoproteins, terpenoids, melanins, nucleosides, etc.) exhibit antiviral activity against many viruses pathogenic for humans. The review presents data on the studied antiviral activities of higher basidial fungi against herpes, West Nile, influenza, human immunodeficiency and hepatitis viruses as well as orthopoxviruses including variola virus. Many species of basidial fungi and various classes of biologically active compounds obtained from them are capable of effectively inhibiting the development of viruses in cells and animals while possessing low toxicity. Biologically active compounds from the same fungal species can exhibit antiviral effects against different pathogens. Effective strains isolated from wild mushrooms in culture represent promising objects for the development of biotechnological drugs, including ones possessing antiviral activity. The data on antitumor and antiviral activities of compounds from the same fungal species indicate the correlation of these properties. In this connection, preparations of basidial fungi may have prophylactic value in preventing cancers of viral etiology.
Проведена оценка водных экстрактов из базидиальных грибов в клеточной культуре Vero на вирусах натуральной оспы и осповакцины. Вируснейтрализующий эффект проявили Inonotus obliquus (чага), Ganoderma applanatum (плоский трутовик), Fomitopsis officinalis (лиственничный трутовик).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.