Antiulcerogenic activity of the extracts of Struthanthus marginatus

Freire, Sonia; Andrade, Karla N. de S.; Aragão, Gilvan A.; Noronha, Elda Pereira; Silva, Selma do N.; Cartágenes, Maria do Socorro de Sousa; Borges, Marilene O. R.; Ribeiro, Maria Nilce de Sousa; Torres, Luce Maria Brandão; Borges, Antônio Carlos Romão

doi:10.1590/s0102-695x2011005000150

Cited by 11 publications

(11 citation statements)

References 23 publications

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“…For example, the species Struthanthus marginatus (Desr.) Blume contains trace elements, including silicon, manganese, iron, copper, and zinc, which could explain its traditional use for wound healing (Freire et al, 2011;Leitão et al, 2013). In another work, rutin was extracted from Struthanthus subtilis Kujit and exhibited in vitro cytotoxic activity against human tumor cell lines (Cordero et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, dosedependent hypotension and cardiotoxic effects were reported for the methanol extract of leaves of Struthanthus venetus (Kunth) Blume (Lorenzana-Jiménez et al, 2006). Leaf extracts of S. marginatus exhibited in vivo protection against gastric lesions induced by ulcerogenic agents without any toxicity, which could justify its popular use for gastric disorders (Freire et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Vittorazzi

Endringer

Andrade

et al. 2015

Pharmaceutical Biology

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Context: Struthanthus vulgaris (Vell.) Mart. (Loranthaceae) has been widely used in traditional medicine in Brazil to bathe wounds. Objective: The objective of this study is to investigate the in vitro wound healing effects, together with the antioxidant and antimicrobial activities of S. vulgaris leaf and branch extracts. Material and methods: Ethanol leaf and branch extracts of S. vulgaris were investigated at 1-100 mg/ml concentrations in the scratch assay after 14 h. Antioxidant activity was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, and the antibacterial activity was tested at concentrations up to 1000 mg/ml against Gram-positive and Gramnegative bacteria by the microdilution test after 24 h. The total phenolic and flavonoid contents were determined by colorimetric methods. Results: Struthanthus vulgaris leaf and branch extracts at 100 mg/ml concentration stimulated migration and proliferation of fibroblasts and enhanced cell numbers by 56.2% and 18.6%, respectively. Antioxidant activity exhibited IC 50 values of 24.3 and 18.9 mg/ml for the leaf and branch extracts, respectively. The ethanol leaf extract showed antimicrobial activity against the Gram-positive Staphylococcus mutans and Staphylococcus aureus bacteria, exhibiting minimum inhibitory concentration values of 125 and 500 mg/ml, respectively. An appreciable total phenolic content in the leaves (813.6 ± 2.7 mg/g) and branches (462.8 ± 9.6 mg/g), and relatively low concentration of flavonoids in the leaves (13.3 ± 4.3 mg/g) and branches (1.9 ± 0.2 mg/g), was detected. Discussion and conclusion: The antioxidant and antibacterial activities, together with the strong ability to stimulate proliferation and migration of fibroblasts, provide some support for the traditional use of S. vulgaris.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Vittorazzi

Endringer

Andrade

et al. 2015

Pharmaceutical Biology

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“…Studies have shown that gastric ulcer occurs in at least 10% of the world's population (Freire et al, 2011;Shimoyama et al, 2013). The etiology of disease is not completely understood, however it is known that the extent of injuries to the gastric mucosa depends on the balance between aggressive and protective factors (Banic´et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Copaifera langsdorffii: evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves

Lemos

Santin

Mizuno

et al. 2015

Revista Brasileira de Farmacognosia

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Revista Brasileira de Farmacognosia 25 (2015) 238-245 w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c tGastric ulcer is a prevalent gastrointestinal disease, and the drugs currently used in the treatment produce several adverse effects. In this context, the search for new therapeutic antiulcer agents is essential, and medicinal plants have great potential. Here, we investigated the gastroprotective properties of Copaifera langsdorffii Desf., Fabaceae, hydroalcoholic extract obtained from leaves and its isolated compounds. The phytochemistry studies and the compounds isolations were performed using chromatographic and spectroscopic methodologies. The hydroalcoholic extract was evaluated using ethanol/HCl, non-steroidal anti-inflammatory drug, stress-induced-ulcer and chronic ulcer-model. The effects on gastric content volume, pH, total acidity and mucus stomach production were evaluated in the pylorus ligated-model. The C. langsdorffii extract obtained from leaves (50, 250 or 500 mg/kg) reduced the injured area compared to control group in all experiments. The extract showed a significant decrease in the total gastric juice acidity and an increase in mucus production (500 mg/kg) when compared to vehicle. Among isolated compounds (30 mg/kg) ␣-humulene, ␤-caryophyllene and caryophyllene oxide showed greater gastroprotective activity in the ethanol/HCl induced ulcer model. The data herein obtained shown that C. langsdorffii leaves extract and isolated compounds from it, presented gastroprotective properties in different animal models of gastric ulcer. These effects may be associated with the ability of the extract to decrease gastric secretion and increase the mucus production.

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“…After 30 min, the animals were euthanized and their small intestines were removed. The distance traveled by the charcoal plug from the pylorus to the cecum was measured and expressed as a percentage of the total intestinal length (adapted from Freire et al, 2011).…”

Section: Small Intestinal Transitmentioning

confidence: 99%

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Monteiro¹,

Carvalho²,

Marques³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Syzygium cumini L. Skeels (Myrtaceae) commonly known as jambolan is used as traditional medicine to treat gastrointestinal disorders in children in Brazil. This work is one of the first to evaluate the antidiarrhoeal and antispasmodic activity of the standardized extract of S. cumini leaves (HESc) in experimental models in vitro and in vivo rodents. Mice pre-treated with HESc (100, 250 and 1000 mg/kg) and atropine (1.0 mg/kg) had reduced intestinal transit velocity of 11.0; 23.2 and19.1%, respectively compared to saline control (46.6±0.9). In isolated rats jejunum, HESc (50, 150 and 300 µg/mL) shifted to the right cumulative concentration-response curves to ACh with changing maximum effect (E max ), which is characteristic of non-competitive antagonism to ACh. HESc also promoted relaxation (E max 90.2±5.8%) in preparations pre-contacted with KCl (75 mM). Additionally, it reduced the maximal CaCl 2 -induced response in 15.4; 56.3 and 92.1% in a concentration-dependent manner. The study results show that HESc has an antidiarrhoeal and spasmolytic potential that can be partly explained by the reduction of intestinal transit velocity and blockage of the voltage-dependent calcium channels in the smooth intestinal muscle.

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Antiulcerogenic activity of the extracts of Struthanthus marginatus

Cited by 11 publications

References 23 publications

Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Copaifera langsdorffii: evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

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