Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip

Bighetti, Aparecida Erica; Antônio, Márcia Aparecida; Kohn, Luciana Konecny; Rehder, Vera Lúcia Garcia; Foglio, Mary Ann; Possenti, Ana; Vilela, Luciane Ribeiro; Carvalho, João Ernesto de

doi:10.1016/j.phymed.2003.09.006

Cited by 120 publications

(83 citation statements)

References 23 publications

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“…20 These plants are used mainly in form of crude extracts, infusions, and medicated dressings. 21 In order to identify new therapeutic agents and to make the use of medicinal plants safer, many groups have been investigating the therapeutic and toxic properties of native and exotic plants. 21,22 Many phytochemical, toxicological, and therapeutic studies of plants have been carried out or are in progress, but much more could be done, given the vast range of plant biodiversity.…”

Section: Resultsmentioning

confidence: 99%

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Souza-Moreira

Salvagnini

Santos

et al. 2011

Journal of Medicinal Food

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The growing list of drug-resistant microorganisms and the persistence of deaths due to diarrhea are compelling reasons to study plants in search of new therapeutic agents. The chemical constitution and popular use of the edible fruits of Campomanesia xanthocarpa O. Berg motivated this study to assess the antimicrobial and antidiarrheal properties of the fruits. An extract in 70% ethanol was prepared, and its antimicrobial activity was tested against several strains of bacteria by the agar diffusion and microdilution methods. Antidiarrheal activity was analyzed by testing intestinal motility in an animal model. Preliminary phytochemical study indicated the presence of flavonoids, saponins, and tannins in the hydroalcoholic extract. Antimicrobial activity was significant, but the minimum inhibitory concentration proved to be higher than the maximum extract concentration tested. The extract did not show significant activity for intestinal motility. Although this fruit extract did not show great results as an antimicrobial or antidiarrheal agent, the study contributes to the search for new plant agents and could be referred to as a research protocol by investigators in this area.

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Section: Resultsmentioning

confidence: 99%

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Souza-Moreira

Salvagnini

Santos

et al. 2011

Journal of Medicinal Food

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“…Warfarin is a particular well-known coumarin which is used as an 0939Ð5075/2008/0100Ð0021 $ 06.00 " 2008 Verlag der Zeitschrift für Naturforschung, Tübingen · http://www.znaturforsch.com · D oral anticoagulant (Pineo and Hull, 2003), but the coumarins also have long been recognized to possess antioxidant (Tyagy et al, 2005), anti-inflammatory (Kontogiorgis and Hadjipavlou-Litina, 2003), antifilarial (Tripathy et al, 2000), antiulcerogenic (Bighetti et al, 2005), trypanocidal (Alvim et al, 2005), antibacterial (Kayser and Kolodziej, 1999), antitumour (Kempen et al, 2003) and anti-HIV activities (Uchiumi et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Coumarins

Montagner

Souza

Groposoa

et al. 2008

Zeitschrift Für Naturforschung C

101

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The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 μg/ml for Fusarium solani and 250 μg/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.

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“…Desses extratos alguns métodos de análise visando separação, purificação e consequentemente o isolamento do marcador químico 1,2-benzopirona tem sido relatados, dentre eles podemos citar, cromatografia em camada delgada, cromatografia em coluna, cromatografia líquida de alta eficiência preparativa, cromatografia líquida de alta eficiência e cromatografia gasosa (Bighetti et al, 2005;Maiorano et al, 2005;Muceneeki et al, 2009;Yatsuda et al, 2005).…”

Section: Processos De Extração Separação E Isolamento De Constituintunclassified

“…Bras. IV, 2005. Tricoma glandular peltado e tricoma glandular unisseriado, com variável número de células na base e com célula terminal esférica ou espatulada são encontrados em depressão na epiderme, sendo este em maior frequência Lucas, 1942;Oliveira et al, 1984Oliveira et al, , 1985aOliveira et al, , 1993Oliveira et al, , 1994Vilegas et al, 1997;Veneziani et al, 1999;Fierro et al, 1999;Magalhães, 2000;Franchi, 2000;Cabral et al, 2001;Moura et al, 2002;Lima & Biasi, 2002;Castro, 2002;Yatsuda et al, 2005Costa et al, 2008;Silva et al, 2008. Cumarina; diidrocumarina; ácido o-cumárico Oliveira et al, 1984Oliveira et al, , 1994Biguetti, 1999;Magalhães, 2000;Lima & Biasi, 2002;Biavatti et al, 2004;Bighetti et al, 2005;Yatsuda et al, 2005;Santos et al, 2006;Graça et al, 2007b. Oliveira et al, 1984Oliveira et al, , 1985aOliveira et al, , 1993Oliveira et al, , 1994Oliveira et al, , 1999Vilegas et al, 1997;Veneziani et al, 1999;Fierro et al, 1999;Moura et al, 2002;Amaral et al, 2003;Yatsuda et al, 2005.…”

Section: Mikania Glomerataunclassified

Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae: estudos agronômicos, genéticos, morfoanatômicos, químicos, farmacológicos, toxicológicos e uso nos programas de fitoterapia do Brasil

Gasparetto¹,

Campos²,

Budel³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:No Brasil as espécies de Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae, popularmente conhecidas como guaco, são amplamente utilizadas com evidências pré-clínicas para o tratamento de doenças onde estejam envolvidas suas ações broncodilatadoras, antialérgicas, antiasmáticas, anti-inflamatórias, antiulcerogênicas e relaxantes da musculatura lisa. Em virtude das propriedades terapêuticas atribuídas as essas espécies, ambas foram oficializadas na farmacopéia brasileira, e por serem bastante semelhantes, dificilmente são diferenciadas. Com o objetivo de contribuir com novas pesquisas, a presente revisão descreve, de forma sistematizada, sobre os aspectos farmacológicos, toxicológicos, químicos, agronômicos, morfoanatômicos, genéticos e o uso nos programas de fitoterapia do Brasil destas espécies. As principais diferenças e semelhanças entre as duas espécies são evidenciadas através da comparação das informações baseadas na literatura específica.Unitermos: Asteraceae, Mikania glomerata, Mikania laevigata, guaco, plantas medicinais.ABSTRACT: "Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae: agronomic, genetic, anatomical, chemical, pharmacological, toxicological studies and its use in herbal therapy programs in Brazil." In Brazil the species of Mikania glomerata Spreng. and M. laevigata Sch. Bip. ex Baker, Asteraceae popularly known as guaco, are widely used with preclinical evidence for the treatment of diseases whose actions involve bronchodilators, antiallergic, anti-asthmatic, anti-inflammatory, antiulcerogenic and smooth muscles relaxant. Due to the therapeutic properties attributed to these species, both were included in the official Brazilian Pharmacopoeia, and because of their similarity, they are hardly differentiated. In order to contribute to the new research, this review describes their several aspects: pharmacology, toxicology, chemical, agricultural, anatomical, genetics and the use in herbal medicine programs in Brazil, in a systematic way. The main differences and similarities between the two species are evidenced by comparing the information based on literature.

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Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip

Cited by 120 publications

References 23 publications

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Antidiarrheal Activity ofCampomanesia xanthocarpaFruit

Antifungal Activity of Coumarins

Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae: estudos agronômicos, genéticos, morfoanatômicos, químicos, farmacológicos, toxicológicos e uso nos programas de fitoterapia do Brasil

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