Antifungal Activity of Coumarins

Abstract

The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 μg/ml for Fusarium solani and 250 μg/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.

Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids

“…Monitoring of the reaction progress and product purification was carried out by TLC. (16 (19). Yield 75% (0.204 mmol, 117 mg); yellow pale oil; IR (cm (25).…”

“…Coumarins and chromones are important classes of compounds having versatile biological activities [14][15][16][17][18][19][20][21][22]. Both moieties are well known for their antiprotozoal activity.…”

Spectral and quantum-mechanical characterizations of 7-amino-4-trifluoromethyl coumarin

“…Coumarins are used as a gain medium in some dye lasers, and as a sensitizer in photovoltaic technologies [1][2]. They have shown some evidence of biological activity (anti-tumor activity and anti-fungal properties [3,4]), but they are approved for few medical uses as pharmaceuticals: the treatment of asthma and lymphedema [5,6]. Coumarins are moderately toxic to the liver and kidneys, with an average lethal dose (LD 50 ) of 275 mg/kg, a low toxicity compared to related compounds.…”

Atividade antioxidante, antimicrobiana e caracterização de compostos bioativos da casca interna de Kielmeyera coriacea Mart. & Zucc

“…Os resultados da atividade antifúngica frente às leveduras C. (SINGH et al, 2011;ZUBRICKÁ et al, 2015, MOKOKA et al, 2013MONTAGNER et al, 2008 A banda de absorbância em 230nm poderia ser atribuída aos flavonoides, já que os taninos condensados são formados por unidades de flavan-3-ol (uma classe de flavonoides).…”

“…5,71 879,1802879,1815 Winterhalter, 2010;Hamed et al, 2014;Rockenbach et al, 2012Rockenbach et al, . 6,72 867,2131Rockenbach et al, 867,2143 EE, PDM, PAE, Fraser, Collette, Hancock, 2016;Souza, 2008Souza, . 5,89 577,1351Souza, 577,1371 EE, PDM, PAE, PBU PA-B (E)Cat-(E)Cat Ge et al, 2017;Rodrigues et al, 2007;Sun et al, 2007;Stefova et al, 2017Stefova et al, .…”