Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models

Kalra, Pankaj; Sharma, Swati; Suman, .; Kumar, Suresh

doi:10.4103/0975-7406.80778

Cited by 45 publications

(15 citation statements)

References 19 publications

(25 reference statements)

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“…Free and total acidity were estimated according to Srivastava et al ( 2010 ) and were expressed as mEq/L. Pepsin activity was measured according to the method of Kalra et al ( 2011 ) and was expressed as μg/mL. For histological assessment, the isolated stomachs were subjected to tissue processing and staining with hematoxylin and eosin (H & E) for histopathological examination which were recorded with 100x lenses.…”

Section: Methodsmentioning

confidence: 99%

GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.

et al. 2017

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Peptic ulceration is among the most prevalent gastrointestinal disorders characterized by pepsin and gastric acid mediated mucosal damage, as result of imbalance between defensive and offensive processes. The main objective of the current study was to investigate the antiulcer potentials of Polygonum hydropiper crude methanolic ectract (Ph.Cr) in aspirin induced ulcerogenesis using pylorus ligated rat model. In-vitro urease and Proteus mirabilis inhibitory potentials were evaluated using standard protocols. All fractions were analyzed using GC-MS to identify major components. The aspirin induced ulcerogenesis in pylorus ligated rat model was associated with significant changes in the mean ulcer score [F(5, 30) = 7.141, P = 0.0002], gastric juice volume [F(5, 30) = 8.245, P < 0.0001], gastric juice pH [F(5, 30) = 5.715, P = 0.0008], free acidity [F(5, 30) = 4.544, P = 0.0033], total acidity [F(5, 30) = 2.740, P = 0.0373], and pepsin concentration [F(5, 30) = 2.335, P = 0.0664]. Pre-treatment with Ph.Cr at 100, 200, and 400 mg/kg dose exhibited marked gastroprotective and anti-ulcerogenic effect in the aspirin induced pyloric ligation ulcerogenesis model at 100, 200, and 400 mg/kg as indicated by ulcerative biochemical parameters. In urease inhibition assay, leaves essential oil (Ph.Lo), saponins (Ph.Sp), and chloroform extract (Ph.Chf) exhibited highest activities with IC50 of 90, 98, and 520 μg/ml, respectively. Ph.Sp, Ph.Chf, ethyl acetate (Ph.EtAc), and Ph.Cr showed MICs of 25, 30, 32.25, and 40.50 μg/ml, respectively against P. mirabilis. Several compounds were identified in GC-MS analysis of samples. Significant in-vivo antiulcer, urease inhibitory as well as anti-proteus potentials of P. hydropiper solvent extracts, signify its potential use for the management of peptic ulcers and may provide scientific bases for the traditional uses of the plant.

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Section: Methodsmentioning

confidence: 99%

GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.

et al. 2017

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“…Tamarindus indica L. is a plant tree indigenous from the tropical Africa and America but also cultivated in several regions, such as China, India, Philippines and Spain. The methanolic extract of the seed coat of this plant (100 mg/kg and 200 mg/kg) has been evaluated for determining their antiulcer potential on ibuprofen, alcohol and pyloric ligation-induced gastric lesions using albino Wistar rats [ 63 ]. The results of this study showed that the methanolic extract reduced total gastric juice volume and free and total gastric secretion acidity in pylorus ligation-induced ulcer model, while reduced ulcer index (comparable with ranitidine, 50 mg/kg, as control) [ 63 ].…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

et al. 2018

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In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.

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“…In Recent Studies . The methanolic extract of the seed coat of T. indica at doses of 100 and 200 mg/kg significantly reduces the total volume of gastric juice and free and total acidity of gastric secretion in pylorus ligation induced ulcer model as compared to control [ 84 ].…”

Section: Findings and Discussionmentioning

confidence: 99%

A Review on Antiulcer Activity of Few Indian Medicinal Plants

Vimala¹,

Shoba²

2014

International Journal of Microbiology

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Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract. Ulceration occurs when there is a disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance. It may be due to the regular usage of drugs, irregular food habits, stress, and so forth. Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. The formation of peptic ulcers depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. A number of synthetic drugs are available to treat ulcers. But these drugs are expensive and are likely to produce more side effects when compared to herbal medicines. The literature revealed that many medicinal plants and polyherbal formulations are used for the treatment of ulcer by various ayurvedic doctors and traditional medicinal practitioners. The ideal aims of treatment of peptic ulcer disease are to relieve pain, heal the ulcer, and delay ulcer recurrence. In this review attempts have been made to know about some medicinal plants which may be used in ayurvedic as well as modern science for the treatment or prevention of peptic ulcer.

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Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models

Cited by 45 publications

References 19 publications

GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.

GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

A Review on Antiulcer Activity of Few Indian Medicinal Plants

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