Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

Sharifi‐Rad, Mehdi; Fokou, Patrick Valère Tsouh; Sharopov, Farukh; Martorell, Miquel; Ademiluyi, Adedayo O.; Rajković, Jovana; Salehi, Bahare; Martins, Natália; Iriti, Marcello; Sharifi‐Rad, Javad

doi:10.3390/molecules23071751

Cited by 156 publications

(92 citation statements)

References 180 publications

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“…Natural products are a rich source of chemical diversity that has boosted pharmaceutical industry over the centuries [1,2]. Plants and herbs have been applied in both prevention and treatment of human disorders since ancient times [3][4][5]. Indeed, many investigations on herbs and plants have been conducted, and their efficacy proved as a compelling source of antioxidant, antimicrobial, anti-inflammatory [6], anticancer and neuroprotective agents [7,8].…”

Section: Introductionmentioning

confidence: 99%

Cucurbita Plants: From Farm to Industry

et al. 2019

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The Cucurbita genus, a member of Cucurbitaceae family, also known as cucurbits, is native to the Americas. Genus members, like Cucurbita pepo and Cucurbita maxima, have been used for centuries in folk medicine for treating gastrointestinal diseases and intestinal parasites. These pharmacological effects are mainly attributed to their phytochemical composition. Indeed, Cucurbita species are a natural source of carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, functional carbohydrates, and polysaccharides, that beyond exerting remarkable biological effects, have also been increasingly exploited for biotechnological applications. In this article, we specifically cover the habitat, cultivation, phytochemical composition, and food preservative abilities of Cucurbita plants.

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Section: Introductionmentioning

confidence: 99%

Cucurbita Plants: From Farm to Industry

et al. 2019

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“…Medicinal plants have been used in human pharmacologic treatments for a long time (Mishra, Saklani, Sharifi‐Rad, Iriti, Salehi, Maurya, et al, ; Mishra, Saklani, Salehi, et al, ; Prakash et al, ; Salehi, Sharopov, et al, ; Salehi, Valussi, et al, ; M. Sharifi‐Rad, Fokou, et al, ; M. Sharifi‐Rad, Nazaruk, et al, ; M. Sharifi‐Rad, Roberts, et al, ). Stevia is one of these species with healthy properties and is used especially in South America and some Asian regions (Lemus‐Mondaca et al, ).…”

Section: From Nutritional Concerns To Therapeutic Applicationsmentioning

confidence: 99%

Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches

Salehi

López

Martínez‐López

et al. 2019

Phytotherapy Research

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Stevia rebaudiana Bertoni, a plant from South America and indigenous of Paraguay, has shown several biological effects and healthy properties, although it is especially used in South America and some Asiatic regions. In addition, it is a natural sweetener, almost 300 times sweeter than sucrose, being attributed to its phytoconstituents prominent antioxidant, antimicrobial, antidiabetic (antihyperglycemic, insulinotropic, and glucagonostatic), antiplatelet, anticariogenic, and antitumor effects. In this sense, this work aims to provide an extensive overview on the historical practices of stevia and its effects in human health based on its chemical composition and applications for both food and pharmaceutical industries.

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“…Historically, plants have been used as a vital source to fullfill shelter, fuel, and food related needs of human beings. On the other hand, plants have always served as a source of folk medicine and modern drugs to meet health care needs of mankind (Gilani & Atta‐ur‐Rahman, ; Mishra et al, ; Mishra et al, ; Saily, Sabu, Mohan, Gupta, & Sondhi, ; Sharifi‐Rad et al, ). Due to the high cost and safety issues of pharmaceutical medicine, there is renewed interest in the utilization of plants/herbs both as a food and medicine (Anwar et al, ; Jamshed, Sultan, Iqbal, & Gilani, ; Muhammad, Hussain, Anwar, Ashraf, & Gilani, ).…”

Section: Introductionmentioning

confidence: 99%

Mentha: A genus rich in vital nutra‐pharmaceuticals—A review

Anwar

Abbas

Mehmood

et al. 2019

Phytotherapy Research

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The genus Mentha comprises several aromatic species, which are cultivated worldover due to their distinct aroma and commercial value. In addition to traditional food flavoring uses, Mentha are well recognized for their folk medicinal uses, especially to treat cold, fever, and digestive and cardiovascular disorders. A number of biological activities such as antioxidant, antimicrobial, biopesticidal, antitumor, anticancer, antiviral, antiallergic, antiinflammatory, antihypertensive, and urease inhibitory activity have been ascribed to Mentha. The traditional pharmacological attributes of Mentha herbs can be linked to the occurrence of bioactive phytochemicals such as terpenoids, alcohols, rosmarinic acid, and antioxidant phenolics among others. A rich source of bioactives, different species of Mentha, can be explored as a promising candidate for the development of nutra-pharmaceuticals. This review covers the nutritional, phytochemical, and traditional medicinal aspects and multiple biological activities of some commonly available species of Mentha so as to explore their potential applications for nutra-pharmaceutical and cosmo-nutraceutical industry. Detailed chemical profile and pharmaceutical attributes of various Mentha essential oils are also covered. Moreover, based on computational analysis, quantitative chemical component-antioxidant activity relationship model is reviewed to predict and correlate structure-activity relationship of potential bioactives in selected Mentha essential oils leading to discovery and developmenmt of novel natural drugs.

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Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

Cited by 156 publications

References 180 publications

Cucurbita Plants: From Farm to Industry

Cucurbita Plants: From Farm to Industry

Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches

Mentha: A genus rich in vital nutra‐pharmaceuticals—A review

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