<i>Stevia rebaudiana</i> Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches

Salehi, Bahare; López, María Dolores; Martínez‐López, Sara; Victoriano, Montserrat; Sharifi‐Rad, Javad; Martorell, Miquel; Rodrigues, Célia Fortuna; Martins, Natália

doi:10.1002/ptr.6478

Cited by 26 publications

(24 citation statements)

References 114 publications

(187 reference statements)

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“…Overproduction of free radicals and defect of antioxidants’ protection involved in the pathogenesis of diabetes was reported in various experimental trials [ 75 , 76 ]. The ability of stevioside to counteract free radicals and reduce oxidative damage has been reported in previous studies [ 77 , 78 , 79 ].…”

Section: Discussionmentioning

confidence: 63%

Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats

2020

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A number of health-promoting properties of Stevia rebaudiana Bertoni and its glycosides, including the antihyperglycemic activity, have been found. The mechanisms of the antidiabetic action of stevia have not been fully understood. The aim of this study was to evaluate the effects of supplementary steviol glycosides on high-fat fed streptozotocin-induced diabetic rats with particular attention to lipid metabolism. The experiment was conducted on 70 male Wistar rats, of which 60 were fed a high-fat diet for 8 weeks followed by intraperitoneal injection of streptozotocin, to induce type 2 diabetes. Afterwards, rats were divided into six groups and fed a high-fat diet supplemented with pure stevioside or rebaudioside A, at two levels (500 or 2500 mg/kg body weight (b.w.)) for 5 weeks. Three additional groups: diabetic untreated, diabetic treated with metformin, and healthy, served as respective controls. Blood and dissected internal organs were collected for hematological, biochemical, and histopathological tests. It was found that dietary supplementation with steviol glycosides did not affect blood glucose, insulin, and insulin resistance indices, antioxidant biomarkers, but normalized hyperlipidemia and affected the appetite, as well as attenuated blood liver and kidney function indices, and reduced tissular damage in diabetic rats. Steviol glycosides normalize lipid metabolism and attenuate internal organs damage in diabetes.

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Section: Discussionmentioning

confidence: 63%

Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats

2020

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“…Clinical trials have proved the effectiveness of several natural compounds in the treatment of dental caries, among which catechol, emetine, quinine, and flavone are the most reported [ 29 , 30 ]. Phytochemicals isolated from plants that can be used as effective and economical treatments are needed [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

et al. 2020

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Dental caries is one of the most common microbe-mediated oral diseases in human beings. At present, the accepted etiology of caries is based on a four-factor theory that includes oral microorganisms, oral environment, host, and time. Excessive exposure to dietary carbohydrates leads to the accumulation of acid-producing and acid-resistant microorganisms in the mouth. Dental caries is driven by dysbiosis of the dental biofilm adherent to the enamel surface. Effective preventive methods include inhibiting the cariogenic microorganisms, treatment with an anti-biofilm agent, and sugar intake control. The goal is to reduce the total amount of biofilm or the levels of specific pathogens. Natural products could be recommended for preventing dental caries, since they may possess fewer side effects in comparison with synthetic antimicrobials. Herein, the mechanisms of oral microbial community development and functional specialization are discussed. We highlight the application of widely explored natural products in the last five years for their ability to inhibit cariogenic microorganisms.

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“…The ability of stevioside to counteract free radicals and reduce oxidative damage has been well-documented [36,37], but the mechanism of action was only recently elucidated. Several studies found that stevioside enhances the endogenous pathway of nuclear factor erythroid 2 related factor 2 (Nrf2) [35,38], a transcription factor that regulates expression of enzymes to counteract oxidative stresses [39].…”

Section: Introductionmentioning

confidence: 99%

Effects of Stevia Rebaudiana on Glucose Homeostasis, Blood Pressure and Inflammation: A Critical Review of Past and Current Research Evidence

Ray¹,

Kumar²,

Laor³

et al. 2020

Int J Clin Res Trials

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In contrast to artificial sweeteners, there are no reported negative health consequences of Stevia, such as toxicity, teratogenicity, mutagenicity or carcinogenicity. In contrast, the anti-hyperglycemic, antioxidant and antihypertensive properties of stevioside have been well documented, suggesting a potential medicinal use as an adjunctive treatment for several diseases. Anti-hyperglycemic PropertiesStevia glycosides have been widely shown to prevent weight gain and decrease serum glucose levels in animal and human models. As with any zero-calorie sweetener, stevia lacks calories and reduces serum glucose levels that typically rise about 1 hour after carbohydrate consumption, compared to sucrose. However, a 2010 study by Kujur et al. found that stevia significantly reduces mean serum glucose levels in subjects over a 1-month period. The study used Wister rats with diabetes induced by 5% alloxan monohydrate, and found that administering 50 mg/kg and 100 mg/kg of stevia daily resulted in significant time-dependent anti-hyperglycemic effects. When treated with 50 mg/kg of stevia in the aqueous, ether and methanolic extracts for 28 days, mean serum glucose levels fell from 220 to 161 mg/dL; 220 to 171 mg/dL; and 232to 163mg/dL, respectively. When treated with 100 mg/kg of the stevia extracts, mean serum glucose levels fell from 220 to 137 mg/dL; 209 to 168 mg/dL; and 218 to 181 mg/dL, respectively. There were non-significant differences in serum glucose levels between the 50mg/kg and 100mg/kg doses. Rats administered glyburide, a known oral diabetes medication that was used as a positive control, hada reduction in mean serum glucose levels from 211 to 101 mg/dL after 28 days. Thus, the administration of stevia

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Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches

Cited by 26 publications

References 114 publications

Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats

Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats

Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

Effects of Stevia Rebaudiana on Glucose Homeostasis, Blood Pressure and Inflammation: A Critical Review of Past and Current Research Evidence

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