Antipsoriatic activity of extracts and fractions obtained from <i>Memecylon malabaricum</i> leaves

Dhanabal, S. P.; Nithyanantham, Muruganantham; Basavaraj, KH; Wadhwani, Asish; Shamasundar, N M

doi:10.1111/j.2042-7158.2012.01528.x

Cited by 11 publications

(10 citation statements)

References 28 publications

(34 reference statements)

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“…In addition, this model allows the histometric and quantitative evaluation of a tested drug response on epidermal differentiation. [34,37,38] The tail skin, unlike other parts of the mouse's body, is histologically and biochemically similar to the human psoriatic skin. The area of the epidermis next to hair follicles and sebaceous glands (interscale area) is analogous to normal and healthy human skin, which presents the granular layer, as the keratinocyte proliferation is orthokeratotic ( Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Antipsoriatic agents are able to induce orthokeratosis and the appearance of the granular layer in the scaling area by decelerating the hyperproliferation phenomenon, which is measured in the mouse tail test. [34,37,39] The absence of the granular layer increases the risk of skin wounds in patients with psoriasis, and it is important to protect the cutaneous tissue against microorganisms, chemicals and ultraviolet radiation. [40] On the other hand, cutaneous atrophy is the most common side effect of topical glucocorticoid drugs, including clobetasol.…”

Section: Resultsmentioning

confidence: 99%

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Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti-inflammatory agent and as adjuvant in psoriasis therapy

Pinto

Maciel

Rezende

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives A previous study reported that the hexane fraction (HF) obtained from Pereskia aculeata leaves showed promising topical anti-inflammatory activity. Intending its future use in clinical practice, a herbal medicine cream named INFLATIV was developed. Its anti-inflammatory and antipsoriatic potential were investigated. INFLATIV was subjected to preliminary accelerated stability tests and to a degradation profile assessment. Methods INFLATIV was prepared at 6% and 12%. The anti-inflammatory activity was assessed by croton oil single and multiple application challenge in mice. Mouse tail test was used for antipsoriatic potential investigation. Cutaneous atrophy test was performed. Preliminary accelerated stability tests were performed together with a degradation profile by GC-MS analysis. Key findings The anti-inflammatory activity shown by INFLATIV was comparable to dexamethasone. However, the skin atrophy caused by that drug was not observed. INFLATIV modified skin parakeratotic differentiation into orthokeratosis, which revealed its antipsoriatic potential. The ingredients used were suitable to carry the bioactives as they were well permeated by the skin. The preliminary accelerated stability tests indicated that INFLATIV 6% is more stable than 12%. Conclusions The results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti-inflammatory agent and as adjuvant in psoriasis therapy

Pinto

Maciel

Rezende

et al. 2020

Journal of Pharmacy and Pharmacology

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show abstract

“…However, there is a need to document these plants with their known efficacy, so that herbal physicians and psoriasis's patient could take advantages of alternative medicine (Capella, Luigi, & Finzi, ). Plant in which in vitro , in vivo, or clinical efficacy has been established are Glycyrrhiza uralensis, Aloe vera (Syed et al, ) , Memecylon malabaricum (Dhanabal, Muruganantham, Basavaraj, Wadhwani, & Shamasundar, ), Capsicum annuum, Psoralea corylifolia , and Mahonia aquifolium. Matricariae flos, Calendulae flos, Hamamelidis folium, Quercus cortex, Violae tricolor, Salviae folium, Echinaceae herba, Dulcamarae stipites, Arnicae flos, Symphyti rhizome, Melaleuca hypericifolia, Melissae folium, Momordica charantia, Azadirachta indica, Arctium lappa, Calendula officinalis, Matricaria recutita, Glycyrrhiza glabra, and Caesalpinia bonduc (Muruganantham et al, ).…”

Section: Management Of Psoriasismentioning

confidence: 99%

“…It is used in constipation, cancer, intestinal worms, cough, and psoriasis. It is cathartic, hypoglycemic, and anti‐psoriatic (Dhanabal, Priyanka, Muruganantham, & Vadivelan, ). Aloe vera is used in psoriasis topically and to clear psoriatic plaques.…”

Section: Management Of Psoriasismentioning

confidence: 99%

Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

Daniyal

Akram

Zainab

et al. 2019

Dermatologic Therapy

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The aim of this study is to review the efficacy of herbal and allopathic drugs used to manage and treat psoriasis. The review has been compiled using reference materials from major databases, Online Journals, Science Direct, Scopus, Open J Gate, Google Scholar and PubMed. Psoriasis is a common skin disease affecting 2–3% of the world's population. It is cosmetically debilitating and chronic disease, which occurs both in developing and developed countries. It can affect any part of the body, but the most common sites are the elbows, knees, and scalp. It is usually treated with synthetic medicine either given systematically or applied locally. The prescribed synthetic medicines used for the treatment of psoriasis are associated with severe side effects and complications, thus researchers around the world are trying to explore new, more effective, and safer drugs from natural resources. Medicinal plants are safe and efficacious, and most of the people all over the world rely on herbal medicine due to their easy availability, low cost, and efficacy for treating psoriasis. A number of medicinal plants having therapeutic potential with high efficacy are used in the treatment of psoriasis have been described. Moreover, studies should be conducted to isolate and investigate the mechanism of actions of phytochemicals responsible for anti‐psoriasis potential.

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“…Thymidine phosphorylase enzyme is reported to be present in high levels in the psoriatic lesion which is likely to induce psoriasis. [9][10][11][12][13][14][15][16] Psoriasis is an autosomal, chronic inflammatory dermatitis affecting 2% of world population. It is present in all racial groups and has a strong genetic component.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-psoriatic Potential of the Fruit Rind of Punica granatum L.

Jacob¹,

Gopalan²,

Lakshmanaperumalsamy³

et al. 2019

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Background: Pomegranate (Punica granatum L.) is universally known for its therapeutic properties due to its potential bioactive compounds. However, there is no established scientific study on antipsoriatic activity of pomegranate fruit rind. The aim of the study is to evaluate the anti-psoriatic activity of the isolated compounds and the extract from the fruit rind of P. granatum. In our previous study, the isolated compounds were evaluated for antioxidant potential. In continuation to the previous investigation, the present study is taken up to evaluate the extract and compounds for in vitro anti-psoriatic activity. Methods: Chromatographic techniques were employed to isolate the compounds from the aqueous acetone extract and in vitro anti-psoriatic activity was determined by thymidine phosphorylase inhibition assay. Results: From previous phytochemical investigation, three compounds were identified as Punicalagin, 2,3(S)-hexahydroxydiphenoyl-D-glucose and Punicalin. In the present study, the extract and the compounds were evaluated for anti-psoriatic activity. The results reveal that the isolated three compounds showed inhibitory activity of 89% to 95% against thymidine phosphorylase. Aqueous acetone extract also exhibited 87% inhibition. Conclusion: Punica granatum is an ideal plant for further investigation to prove its anti-psoriatic activity.

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Antipsoriatic activity of extracts and fractions obtained from Memecylon malabaricum leaves

Abstract: The findings of this investigation reveal that the leaves of M. malabaricum have good antipsoriatic potential, which provides scope for further detailed research in to this plant for psoriasis.

Cited by 11 publications

References 28 publications

Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti-inflammatory agent and as adjuvant in psoriasis therapy

Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti-inflammatory agent and as adjuvant in psoriasis therapy

Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

Evaluation of Anti-psoriatic Potential of the Fruit Rind of Punica granatum L.

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