Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

Daniyal, Muhammad; Akram, Muhammad; Zainab, Rida; Munir, Naveed; Shah, Syed Muhammad Ali; Liu, Bin; Wang, Wei; Riaz, Muhammad; Jabeen, Farhat

doi:10.1111/dth.12866

Cited by 20 publications

(11 citation statements)

References 46 publications

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“…[3][4][5] Psoriasis is a common chronic inflammatory skin disease which has a prevalence of 2% to 4% worldwide. 6,7 Nail involvement in psoriasis is common, with an estimated lifetime incidence of 80%-90% and a varying prevalence of 15%-79%. 8 Nail psoriasis (NP) not only affects nail functions, it is often associated with severe pain.…”

Section: Backg Rou N Dmentioning

confidence: 99%

Dysbiosis of nail microbiome in patients with psoriasis

Wang

Song

et al. 2022

Experimental Dermatology

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Shifts in skin microbiome are considered to be involved in the pathogenesis of psoriasis. However, data on the microbial dysbiosis of nail psoriasis are scarce. In this study, we aim to investigate and characterize the nail bacterial and fungal microbiome in patients with psoriasis. Nail samples were collected prospectively from 36 subjects with nail psoriasis, 24 psoriatic subjects without nail involvement and 32 healthy controls. Amplicon sequencing was performed to evaluate the bacterial and fungal community compositions. Significant alterations in the bacterial microbiome were found in the nail samples of psoriatic patients. The unaffected nails in psoriatic patients were associated with higher bacterial diversity, and a higher relative abundance of Enhydrobacter, whereas nail psoriasis was correlated with a decreased relative abundance of Anaerococcus. Shifts in fungal community composition were reflected by a higher proportion of Malassezia in the unaffected nails of psoriatic patients and an increased proportion of Candida in psoriatic nails. Shifts in the nail microbiome in psoriasis suggest a potential role of microbes in the development of nail psoriasis. Future researches focusing on these microorganisms may help to explain the pathogenesis of psoriasis.

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Section: Backg Rou N Dmentioning

confidence: 99%

Dysbiosis of nail microbiome in patients with psoriasis

Wang

Song

et al. 2022

Experimental Dermatology

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“…Moreover, several clinical studies support the skin protective effects of polyphenols and their dermatological applications 33‐35 . The skin protective effects of dietary polyphenols as well as their therapeutic potential for the treatment of skin disorders have been reviewed in several articles 32,36‐38 . For instance, the skin protective effects of honey, a natural sweetener, has been supported by empirical evidence and modern scientific studies 39,40 .…”

Section: Translational Therapeutic Implications Of Our Researchmentioning

confidence: 99%

Phenolic‐enriched maple syrup extract protects human keratinocytes against hydrogen peroxide and methylglyoxal induced cytotoxicity

Sheng

Liu

Petrovas

et al. 2020

Dermatologic Therapy

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Reactive carbonyl species including methylglyoxal (MGO) are oxidation metabolites of glucose and precursors of advanced glycation end products (AGEs). They are important mediators of cellular oxidative stress and exacerbate skin complications. Published data supports that certain phenolic compounds can exert cellular protective effects by their antioxidant activity. A phenolic‐enriched maple syrup extract (MSX) was previously reported to show protective effects against AGEs‐ and MGO‐induced cytotoxicity in human colon cells but its skin protective effects remain unknown. The protective effects of MSX were evaluated against hydrogen peroxide (H2O2)‐ and MGO‐induced cytotoxicity in human keratinocytes (HaCaT cells). Cellular viability and antioxidant activity were evaluated by the luminescent cell viability CellTiter‐Glo assay and the reactive oxygen species (ROS) assay, respectively. A single‐cell gel electrophoresis (Comet assay) was used to measure the strand breaks in the DNA of HaCaT cells. MSX (at 50 μg/mL) ameliorated H2O2‐ and MGO‐induced cytotoxicity by increasing cell viability by 21.5% and 25.9%, respectively. MSX reduced H2O2‐ and MGO‐induced ROS production by 69.4% and 56.6%, respectively. MSX also reduced MGO‐induced DNA damage by 47.5%. MSX showed protective effects against H2O2‐ and MGO‐induced cytotoxicity in HaCaT cells supporting its potential for dermatological and/or cosmeceutical applications.

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“…1,2 Psoriasis is estimated to affect about 2-3% of the world's population (approximately 125 million people), mostly in the adult age range of 18-39 years. [3][4][5] Atopic dermatitis also affects 1-10% of adults and 15-20% of children worldwide. 6 Although both psoriasis and AD are considered skin diseases, numerous studies have shown that these diseases are associated with other complications.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of hydrotherapy, spa therapy, and balneotherapy for psoriasis and atopic dermatitis: a systematic review

et al. 2022

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Background Atopic dermatitis (AD) and psoriasis are chronic inflammatory diseases that have significant skin complications. Objective The purpose of this systematic study was to evaluate the evidence obtained from human studies on the effects of hydrotherapy, spa therapy, and balneotherapy in psoriasis and atopic dermatitis. Methods The present systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) statements. Also, for this study databases such as Embase, PubMed, Scopus ProQuest, and sciences direct database were searched from the beginning to April 2021. Results All human studies that examined the effect of balneotherapy, spa therapy, and hydrotherapy on psoriasis and atopic dermatitis were published in the form of a full article in English. In the end, only 22 of the 424 articles met the criteria for analysis. Most studies have shown that balneotherapy, spa therapy, and hydrotherapy may reduce the effects of the disease by reducing inflammation and improving living conditions. In addition, the results of the Downs and Black score show that seven studies received very good scores, three studies received good scores, nine studies received fair scores, and three studies received poor scores. Conclusions The results of studies also showed that hydrotherapy leads to an improvement in the PASI score index. Nevertheless, more clinical trials are needed to determine the mechanism of action of hydrotherapy on these diseases.

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Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

Cited by 20 publications

References 46 publications

Dysbiosis of nail microbiome in patients with psoriasis

Dysbiosis of nail microbiome in patients with psoriasis

Phenolic‐enriched maple syrup extract protects human keratinocytes against hydrogen peroxide and methylglyoxal induced cytotoxicity

Efficacy of hydrotherapy, spa therapy, and balneotherapy for psoriasis and atopic dermatitis: a systematic review

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