Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti-inflammatory agent and as adjuvant in psoriasis therapy

Abstract

Objectives A previous study reported that the hexane fraction (HF) obtained from Pereskia aculeata leaves showed promising topical anti-inflammatory activity. Intending its future use in clinical practice, a herbal medicine cream named INFLATIV was developed. Its anti-inflammatory and antipsoriatic potential were investigated. INFLATIV was subjected to preliminary accelerated stability tests and to a degradation profile assessment. Methods INFLATIV was prepared at 6% and 12%. The anti-inflammatory activity was assessed by croton oil single and multiple application challenge in mice. Mouse tail test was used for antipsoriatic potential investigation. Cutaneous atrophy test was performed. Preliminary accelerated stability tests were performed together with a degradation profile by GC-MS analysis. Key findings The anti-inflammatory activity shown by INFLATIV was comparable to dexamethasone. However, the skin atrophy caused by that drug was not observed. INFLATIV modified skin parakeratotic differentiation into orthokeratosis, which revealed its antipsoriatic potential. The ingredients used were suitable to carry the bioactives as they were well permeated by the skin. The preliminary accelerated stability tests indicated that INFLATIV 6% is more stable than 12%. Conclusions The results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies.

Baccharis dracunculifolia DC (Asteraceae) Root Extract and Its Triterpene Baccharis Oxide Display Topical Anti‐Inflammatory Effects on Different Mice Ear Edema Models

“…The considerable increase in ear thickness and edema formation promoted by croton oil was inhibited by the application of BdR and BOx. Croton oil contains a series of phorbol-12, 13-diesters, which activates protein kinase C and other inflammatory mediators, promoting irritant and cutaneous signs similar to psoriasis [ 28 , 29 ]. Also, topical application of croton oil triggers local inflammation, inducing edema and erythema, also increasing vascular permeability, leukocytes infiltration, synthesis of eicosanoids, and liberation of histamine and serotonin [ 19 ].…”

Influence of Harvest Time on the Chemical Profile of Pereskia aculeate Mill. Using Paper Spray Mass Spectrometry

“…Due to their anti-inflammatory and antinociceptive activities, GBB leaves may have an important role in the pharmaceutical industry. Recently, a phytotherapeutic cream was developed based on P. aculeata leaves and researchers tested its anti-inflammatory and anti-psoriatic potential, demonstrating the therapeutic relevance and marketing associated with the use of this species [11].…”