Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts of<i>Sida acuta</i>leaf on<i>Plasmodium berghei</i>-infected animals

Adesina, Daniel Anuoluwa; Adefolalu, Sherifat Funmilola; Jigam, Ali A.; Lawal, Bashir

doi:10.1080/16583655.2020.1790912

Cited by 27 publications

(21 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, some Sida secondary metabolites including stigmasterol and its derivative, stigmasterol-3-O-β-D-glucopyranoside, have been shown to exhibit antimalarial properties [53,78]. Similarly, the presence of high levels of flavonoids, alkaloids, terpenoids and tannins which have been known to have antimalarial and chemoprotective activities could be responsible for the findings of the present study [27,79,80]. This study has some limitations such as the inability to track the specific compounds responsible for the antimalarial activities of EESAL and characterize them and inability to evaluate the specific mechanism of killing the parasites by EESAL.…”

Section: Discussionsupporting

confidence: 60%

“…Filtrates from the extraction chambers were dried (rotary evaporator at 45 °C), obtaining crude ethanol leaf extract of S. acuta (EESAL) (13.32%). Ethanol was used as a solvent in this study based on the traditional practice where the leaves are soaked in ethanol for 2-3 days and the decoction orally taken for 4-7 days to treat malaria [16,26,27]. In addition, results of pilot study conducted using different solvent extracts showed that ethanol extract has significantly higher activity compared to n-hexane, ethyl acetate, water and chloroform extracts (data not shown).…”

Section: Extraction Of Plant Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Sida acuta Burm.f. leaves ethanol extract ameliorates haematological and biochemical alterations induced by Plasmodium berghei ANKA-65 in mice

et al. 2021

View full text Add to dashboard Cite

Background Malaria has continued to be a threat to man and his wellbeing, especially Africans and Asians. New antimalarial drugs are urgently needed to mitigate malaria treatment failure due to resistant Plasmodium species. Medicinal plants used by indigenous Nigerians for treating fever and malaria such as Sida acuta Burm.f. (Malvaceae) could be a promising source of lead compounds for developing new generations of antimalarial drugs. The effects of ethanol extract of S. acuta leaves (EESAL) on malaria parasitemia, haematological and biochemical status of P. berghei-infected mice were investigated, using the 4-day curative test. Methodology EESAL was prepared by maceration method. The phyto-constituents and acute toxicity profile of the extract were evaluated using standard protocols. In addition, malaria parasitemia and chemo-suppression, and indicators of haematological and biochemical status of P. berghei-infected mice treated with EESAL were assessed. Results At 200, 400 and 600 mg/kg/d b.w., p.o doses for 4 consecutive days, EESAL significantly (p < 0.05) decreased parasitaemia and suppressed malaria parasite by 89.64%, 95.95% and 97.38%, respectively comparable to negative control. The reduction in percentage malaria parasitemia by EESAL is comparable to Artemether (140 mg/kg/d b.w., p.o) used as standard antimalarial drug in this study. The packed cell volume (PCV), haemoglobin (Hb) concentration, and red blood cell (RBC) and white blood cell (WBC) counts of negative control are significantly (p < 0.05) higher than normal control. However, parasitized-EESAL-treated mice have significantly (p < 0.05) higher PCV value, Hb concentration and RBC and WBC counts than negative control. Similarly, treatment of parasitized mice with EESAL restored some indicators of the antioxidant, lipid peroxidation, lipid profile and liver status altered by malaria. In addition, EESAL was tolerable up to 5000 mg/kg b.w., p.o. Conclusion These results indicate that the EESAL possesses antimalarial activity and normalizes alterations in haematological and biochemical status of malaria-infected mice.

show abstract

Section: Discussionsupporting

confidence: 60%

Section: Extraction Of Plant Materialsmentioning

confidence: 99%

Sida acuta Burm.f. leaves ethanol extract ameliorates haematological and biochemical alterations induced by Plasmodium berghei ANKA-65 in mice

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Evidence for the anti-inflammatory properties of flavonoids and alkaloids have been reported by several studies using different models of inflammation [24][25][26]. The significant anti-inflammatory effects demonstrated by the purified fraction of M. senegalensis leaf could be mechanistically explained by the fact that phyochemicals are known to inhibit the enzymes involved in the production of inflammatory mediator including cyclooxygenase and 5-lipoxygenase pathways [27].…”

Section: Discussionmentioning

confidence: 99%

Characterization of anti-plasmodial, analgesic and anti-inflammatory fraction of Maytenus senegalensis (lam.) Exell leaf extract in mice

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: The treatment inadequacy and toxicity associated with conventional anti-malarial, anti-inflammatory and analgesic drugs has called for the search of alternatives from medicinal plants, particularly, their phytochemicals with inherent pharmacological properties. In the present study, purified fraction of M. senegalensis leaf was evaluated for antimalarial, anti-inflammatory and analgesic properties. Method: Antimalarial study was conducted against Plasmodium chabaudi and Plasmodium berghei using 4 days suppressive test, while anti-inflammatory and analgesic studies were conducted using egg albumin induced paw oedema and acetic acid induced pain model respectively. Sub-acute toxicity was assessed using serum biochemical parameters following 3 weeks administrations of the purified fraction. Results: The purified fraction of M. senegalensis leaf shows dose dependent antiplasmodial activity with percentage curative effects of 15.24 ± 0.89, 45.70 ± 3.43 and 48.50 ± 4.56 at 75, 150 and 300 mg/kg bw against Plasmodium chabaudi and % curative effects of 44.25 ± 3.21, 72.74 ± 6.54 and 76.30 ± 8.32 respectively against Plasmodium berghei. The purified fraction exhibited 53.16 ± 4.09 and 60.76 ± 7.54 anti-inflammatory effect, 43.35 ± 4.98% and 44.83 ± 3.86% analgesic effect at 75 and 150 mg/kg bw respectively. GC-MS analysis confirmed the presence of 20α)-3-hydroxy-2-oxo-24-nor-friedela-1(10),3,5,7-tetraen-carboxylic acid-(29)-methylester, 2(4H)-Benzofuranone, 5,6,7, 7a-tetrahydro-and 3-hydroxy-20(29)-lupen-28-ol and a terpenes (phytol) as the major antimalarial compounds in the fraction. The purified fraction increases the serum total proteins and transaminases concentrations but had no effect on serum levels of sodium, potassium, chloride, alkaline phosphatase, triglyceride and glucose in the mice. Conclusion: The purified fraction of M. senegalensis leaf exhibited promising antimalarial, analgesic and antiinflammatory activities. Thus, could serve as a template for the synthesis of new drug.

show abstract

“…Natural products, particularly medicinal plants have been used from time immemorial for the treatment of various diseases (41)(42)(43) and various studies have recommended the evaluation of medicinal plants in order to accept their use for medicinal purposes (44)(45)(46)(47)(48)(49)(50). It is therefore noteworthy that Dennettia tripetala demonstrated safety profile in toxicity study, in addition to its various biological activities, and thus serve as an important medicinal plant worthy of further preclinical evaluation…”

Section: Toxicity Of Dennettia Tripetalamentioning

confidence: 99%

Dennettia tripetala (Pepper Fruit), a review of its ethno-medicinal use, phyto-constituents, and biological properties

Muhammed¹,

Adebiyi²,

Odey³

et al. 2021

GSC Adv. Res. Rev.

View full text Add to dashboard Cite

There has been tremendous growth in field of herbal medicine as therapeutic agents. Dennettia tripetala, is known to possess ethnomedicinal properties and has been used for centuries in the Ayurvedic system of medicine for the treatments of various diseases. The present review provides detailed description on the distribution, ethno-medicinal use, phyto-constituents, and biological properties of the plant that justifies its use as a potential therapeutic agent in management of different diseases. The phyto chemical composition of Dennettia tripetala include alkaloids, tannins, saponins, flavonoids, terpenoids, steroids and cardiac glycosides while it biological activities include antioxidant, antidiabetic, antibacterial, antihypertensive, anticonvulsant, antitrypanosomal, antimalarial, anti-inflammatory and cytotoxic properties among others. In conclusion, Dennettia tripetala contains various nutritional and phytochemicals compositions that make it valuable for pharmacological purposes.

show abstract

Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts ofSida acutaleaf onPlasmodium berghei-infected animals

Cited by 27 publications

References 42 publications

Sida acuta Burm.f. leaves ethanol extract ameliorates haematological and biochemical alterations induced by Plasmodium berghei ANKA-65 in mice

Sida acuta Burm.f. leaves ethanol extract ameliorates haematological and biochemical alterations induced by Plasmodium berghei ANKA-65 in mice

Characterization of anti-plasmodial, analgesic and anti-inflammatory fraction of Maytenus senegalensis (lam.) Exell leaf extract in mice

Dennettia tripetala (Pepper Fruit), a review of its ethno-medicinal use, phyto-constituents, and biological properties

Contact Info

Product

Resources

About