Antioxidative Stress Mechanisms behind Resveratrol: A Multidimensional Analysis

Gu, Tongyu; Wang, Nianmin; Wu, Tong; Ge, Qi; Chen, Liang

doi:10.1155/2021/5571733

Cited by 32 publications

(23 citation statements)

References 109 publications

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“…Concerning the histopathological changes, the results confirmed the ability of H2O2 to induce progressive adverse effects on the components of the cell as illustrated in figures belonging to group G1, maybe due to LPO and oxidative stress, which led to increases in intracellular calcium, activates membrane phospholipid proteases, mitochondrial dysfunction (3), glomerular tuft degeneration and promote the initiation of autophagy and apoptosis in the different pathway (29). Current observations showed that resveratrol rescued renal histopathological damage against H2O2.…”

Section: Discussionsupporting

confidence: 66%

Renal ameliorating effect of resveratrol in hydrogen peroxide induced male rats

Khudair

Al-Okaily

2022

IJVS

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The study aimed to investigate the potential effect of resveratrol (RS) supplementation in attenuating kidney injury induced by hydrogen peroxide (H2O2) in male rats. Forty adult male rats were randomly assigned into four groups (10 each). The control group was orally supplemented with distilled water, and group G1 was orally supplemented with tap water containing 0.5% of H2O2, G2: was orally supplemented with tap water containing 0.5% of H2O2 and RS 87 mg/kg BW, and G3 was orally supplemented with RS 87 mg/kg BW. Blood samples were obtained before treatment and after 45 days of daily treatment. Serum concentrations of creatinine (Cr), urea nitrogen (UN), and total bilirubin were assessed. On day 45, male rats were euthanized, and kidney samples were taken to estimate malondialdehyde (MDA) and superoxide dismutase (SOD) concentrations, and other samples were obtained for histopathological examination. The results showed a significant increase in creatinine and BUN concentrations accompanied by a significant increase in MDA and a decrease in SOD in kidney tissue in G1 group male rats compared to other groups. Resveratrol partially restored the studied criteria related to renal functions by modulating the histopathological changes in the kidney induced by hydrogen peroxide. It could be concluded that supplementation of resveratrol to oxidatively stressed rats maintains the antioxidant defenses mechanism and could be helpful in the prevention of renal oxidative stress.

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Section: Discussionsupporting

confidence: 66%

Renal ameliorating effect of resveratrol in hydrogen peroxide induced male rats

Khudair

Al-Okaily

2022

IJVS

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“…Although resveratrol is able to directly scavenge a variety of free radicals, its main antioxidant effect is more properly due to its regulation of redox genes [20]. SOD1 is one of the three superoxide dismutases known to catalyse the dismutation of superoxide (O 2 − ) to hydrogen peroxide (H 2 O 2 ) and O 2 ; at the same time, GPX1 and CAT catalyse the rapid decomposition of H 2 O 2 while GSR is involved in the glutathione-dependent antioxidant system by reducing oxidized glutathione [57].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the well-established role of oxidative stress in Cd reproductive toxicity, developing defence strategies using antioxidants is a growing field of study [19]. Resveratrol (Res; 3,4,5-trihydroxy-trans-stilbene), a phytoalexin produced by plants, is one of the most studied polyphenol with well-established antioxidant properties [20]. Several studies in various species provided evidence that Res could act as a powerful antioxidant being able to prevent the disruption of oocyte redox homeostasis and the decline of the oocyte quality and to improve oocyte IVM, IVF and subsequent embryonic development rates [21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization

Piras

Ariu

Maltana

et al. 2022

J Animal Sci Biotechnol

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Background Heavy metal cadmium (Cd) is a widespread environmental contaminant with a potential toxicity that might negatively affect female reproduction and fertility. It has been reported that Cd exposure impaired the quality of oocytes and led to a defective maturation and fertilization, through oxidative stress induction. Resveratrol (Res) is a natural polyphenol with strong antioxidant properties that exhibited protective role in preventing oocyte redox homeostasis disruption and quality decline. Here, we explored whether the addition of Res to in vitro maturation (IVM) medium might act as a protection against Cd-induced toxicity on ovine oocyte maturation and fertilization. Firstly, we evaluated the effect of supplementing IVM medium with two different Res concentrations (1 and 2 μmol/L) on nuclear maturation and fertilization of oocytes matured under CdCl2 (2 μmol/L) exposure. Therefore, the concentration of 1 μmol/L Res was selected to analyse the effects of this compound on intracellular ROS levels, mitochondrial (mt) distribution and activity, chromatin configuration, cytoskeleton morphology, cortical granules (CGs) distribution and mRNA expression of genes associated with cellular response to oxidative stress (i.e. SIRT1, SOD 1, GPX1, GSR, CAT) in Cd-exposed in vitro matured oocytes. Results We found that 1 μmol/L Res restored the reduced oocyte meiotic competence induced by Cd exposure as well as, Res sustained oocyte ability to be normally fertilized and decreased polyspermic fertilization at both tested concentrations. Moreover, we demonstrated that 1 μmol/L Res mitigated Cd-induced alterations of oocyte cytoplasmic maturation by reducing reactive oxygen species (ROS) accumulation, preventing mt dysfunction, maintaining the correct meiotic spindle and cortical F-actin assembly and the normal cortical granule distribution as well as up-regulating SIRT1, SOD1 and GPX1 genes. Conclusions Taken together, our findings highlighted the beneficial influence exerted by Res in preventing Cd-induced disturbance of nuclear and cytoplasmic maturation and subsequent fertilization in ovine oocytes. Res treatment may help to establish defence strategies counteracting Cd-induced toxicity on the female gamete.

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“…1,2 However, there must be an equilibrium between oxidants and antioxidants in living organisms and any deviation in this balance can be harmful either as oxidative stress or antioxidative stress. 1,3 Medicinal plants have attracted immense attention due to their high antioxidant capacity. A large amount of evidence has shown that there is a positive relationship between flavonoid and phenolic contents and antioxidant activity of plant organs.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Phenolic and Flavonoid Contents, Antioxidant Properties, and Antimicrobial Activities of Stocksia Brahuica Benth

Ebrahimnezhad

Dehghani

Beyzaei

2022

Int J Basic Sci Med

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Introduction: Stocksia brahuica Benth. (Sapindaceae) is an invaluable shrubby plant distributed in Iran, Afghanistan, and Balochistan region of Pakistan. In this study, the total phenolic and flavonoid contents and the antioxidant and antimicrobial properties of leaf, fruit, and seed extracts of S. brahuica were screened. Methods: Plant materials were collected in September 2021 from Zahedan, southeast of Iran. The total phenolic and flavonoid contents and total antioxidant capacity were assessed spectrophotometrically using Folin-Ciocalteu, aluminum chloride colorimetric, and DPPH free radical scavenging methods, respectively. The effectiveness of crude hydroethanolic extracts of the leaf, fruit, and seed of Stocksia brahuica were also assayed against four gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli) and two gram-positive bacteria (Staphylococcus epidermidis and Streptococcus pyogenes) as well as two fungi (Aspergillus fumigatus and Candida albicans). Results: The total phenolic and flavonoid contents were observed to vary from 136.7 to 263.5 mg gallic acid equivalents/g and 26.6 to 104.8 mg quercetin equivalents/g of powdered dry weight. The highest amounts of phenolic and flavonoid content were detected in leaves. Good antioxidant activities were observed with leaves followed by fruits and seeds. Based on our antimicrobial experiments, some plant organs were successful in blocking the growth of tested pathogenic strains. Conclusion: As a result, natural products derived from this plant can make a significant contribution to the development of the nutritional and pharmaceutical industries.

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Antioxidative Stress Mechanisms behind Resveratrol: A Multidimensional Analysis

Cited by 32 publications

References 109 publications

Renal ameliorating effect of resveratrol in hydrogen peroxide induced male rats

Renal ameliorating effect of resveratrol in hydrogen peroxide induced male rats

Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization

Assessment of Phenolic and Flavonoid Contents, Antioxidant Properties, and Antimicrobial Activities of Stocksia Brahuica Benth

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