Antioxidant synergistic effects of Osmanthus fragrans flowers with green tea and their major contributed antioxidant compounds

Mao, Shuqin; Wang, Kaidi; Lei, Yukun; Yao, Shuting; Lu, Baiyi; Huang, Wen

doi:10.1038/srep46501

Cited by 40 publications

(24 citation statements)

References 35 publications

(38 reference statements)

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“…Over produced ROS generates oxidative stress which can be reduced through antioxidant . Antioxidants can not only scavenge the ROS in body but can also regulate ROS related enzymes such as radical generating NAD(P)H oxidase and xanthine oxidase (XO) or radical reducing superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) . Out of these enzymes, SOD converts two O 2 .− into one H 2 O 2 and one oxygen molecule;

true normalO_{2}^{•}^{-} + normalO_{2}^{•}^{-} + 2 H^{+} \overset{SOD}{true} normalO_{2} + normalH_{2} normalO_{2}

…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

et al. 2019

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The in vivo determination of radical scavenging activity of flavonoids (Fls) and their metal complexes (M‐Fls) through co‐administration of 2‐hydroxypropyl beta‐cyclodextrin (HP‐βCD) was determined. The flavonoids morin (mo), quercetin (quer), primuletin (prim), their Cu (II) and Fe (III) complexes were selected to explore their radical scavenging potential. Metal complexes of flavonoids (M‐Fls) showed better radical scavenging activity RSA when injected to rats than corresponding flavonoids. The RSA is improved in the presence of HP‐βCD. This increase in RSA was assisted by enhanced enzymatic activity of catalase (CAT) and superoxide dismutase (SOD) activity. The compounds displayed hepatoprotection against alloxan induced liver damage as flavonoid injected group displayed lower levels of enzymes and intermediates aspartate/alanine transaminase (AST), alanine aminotransferase (ALT), Lipid peroxidation (MDA), Hydroxyproline (HYP), Sailic acid (SA) and higher albumin and total proteins level compared with alloxan treated group. It was evaluated by histopathological investigations that M‐Fls restored the hepatic damage caused by alloxan. The binding constants values of the compounds with human plasma (n‐HP) revealed the order of 103‐104 L−1. The binding interactions of the compounds with human plasma in the presence of HP‐βCD is decreased which in turns increased the RSA as well as CAT and SOD activities. Based upon our results, it was concluded that radical scavenging activities and hepatoprotective activities of M‐Fls is increased when co‐administrated with HP‐βCD.

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true normalO_{2}^{•}^{-} + normalO_{2}^{•}^{-} + 2 H^{+} \overset{SOD}{true} normalO_{2} + normalH_{2} normalO_{2}

…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

et al. 2019

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“…This is particularly important because previous observations suggest that polyphenolic mixtures show fewer side effects than the pure compounds due to interactions among themselves. 32 , 33 Our studies reveal that the antioxidant activity [2,2-diphenyl-1-picrylhydrazyl (DPPH) assay] of the Pb–morin complex is sustainable compared to that of Pb-free morin. We have also found that the solubility of the Pb–morin complex increases significantly compared to that of morin in an aqueous environment.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial

Adhikari

Darbar²,

Chatterjee

et al. 2018

ACS Omega

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Ubiquitousness in the target organs and associated oxidative stress are the most common manifestations of heavy-metal poisoning in living bodies. While chelation of toxic heavy metals is important as therapeutic strategy, scavenging of increased reactive oxygen species, reactive nitrogen species and free radicals are equally important. Here, we have studied the lead (Pb) chelating efficacy of a model flavonoid morin using steady-state and picosecond-resolved optical spectroscopy. The efficacy of morin in presence of other flavonoid (naringin) and polyphenol (ellagic acid) leading to synergistic combination has also been confirmed from the spectroscopic studies. Our studies further reveal that antioxidant activity (2,2-diphenyl-1-picrylhydrazyl assay) of the Pb–morin complex is sustainable compared to that of Pb-free morin. The metal–morin chelate is also found to be significantly soluble compared to that of morin in aqueous media. Heavy-metal chelation and sustainable antioxidant activity of the soluble chelate complex are found to accelerate the Pb-detoxification in the chemical bench (in vitro). Considering the synergistic effect of flavonoids in Pb-detoxification and their omnipresence in medicinal plants, we have prepared a mixture (SKP17LIV01) of flavonoids and polyphenols of plant origin. The mixture has been characterized using high-resolution liquid chromatography assisted mass spectrometry. The mixture (SKP17LIV01) containing 34 flavonoids and 76 other polyphenols have been used to investigate the Pb detoxification in mouse model. The biochemical and histopathological studies on the mouse model confirm the dual action in preclinical studies.

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“…Acteoside, isoacteoside, and 6'-acetylacteoside contain hydroxyphenylethyl and caffeoyl moieties that are known to be associated with antioxidant properties [35,36], and acteoside itself exhibits considerable antioxidant activity [37]. Studies have shown that acteoside inhibits the aggregation of β-amyloid peptide (Aβ) in a dosedependent manner, functions as a neuroprotective agent, and enhances memory, and these properties have been attributed to the antioxidant activity of the agent [38,39].…”

Section: Resultsmentioning

confidence: 99%

Isolation and Identification of Phenylethanoid Glycosides from Aloysia polystachya and Its Activity as Inhibitors of Monoamine Oxidase-A

Pereira

Guimarães

Pereira

et al. 2019

PMIO

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Aloysia polystachya is used as a sedative and antidepressant by the indigenous populations of Argentina and Paraguay, but the compounds associated with these activities have not been determined. We have separated and identified the main constituents of the hydroethanolic extract of A. polystachya by ultra-performance liquid chromatography-mass spectrometry and confirmed the presence of acteoside, isoacteoside, 6'-acetylacteoside, and 4’,4’’’,5,5’’-tetrahydroxy-6,6’’,3’’’-trimethoxy-[C7–O–C7’’]-biflavone by NMR spectroscopy. Inhibitory activities of the hydroethanolic extract and purified phenylethanoid glycosides against monoamine oxidase-A were assessed using a standard fluorometric assay. The hydroethanolic extract inhibited monoamine oxidase-A activity in a dose-dependent manner with an IC50 of 9.2 µg/mL, while the selective monoamine oxidase inhibitor clorgyline exhibited an IC50 of 0.06 µg/mL (0.22 µM). Acteoside was the strongest inhibitor of monoamine oxidase-A (IC50 value of 5 µM), whereas isoacteoside and 6'-acetylacteoside showed IC50 values of around 10 µM. The results showed that phenylethanoids from a hydroethanolic extract of A. polystachya have been found to have inhibitory activity against monoamine oxidase-A. It is likely that the mode of action of the acteosides is multi-targeted, involving the downregulation of inflammatory molecules and neutralization of oxidation reactions as well as inhibition of monoamine oxidase-A.

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Antioxidant synergistic effects of Osmanthus fragrans flowers with green tea and their major contributed antioxidant compounds

Cited by 40 publications

References 35 publications

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial

Isolation and Identification of Phenylethanoid Glycosides from Aloysia polystachya and Its Activity as Inhibitors of Monoamine Oxidase-A

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