Isolation and Identification of Phenylethanoid Glycosides from Aloysia polystachya and Its Activity as Inhibitors of Monoamine Oxidase-A

Pereira, Ana Maria Soares; Guimarães, Camila Carla; Pereira, Sarazete Izidia Vaz; Crevelin, Eduardo José; Pinto, Gustavo Henrique Teixeira; Morel, Lucas Junqueira de Freitas; Bertoni, Bianca Waléria; França, Suzelei de Castro; Contini, Sílvia Helena Taleb

doi:10.1055/a-0787-1665

Cited by 8 publications

(11 citation statements)

References 37 publications

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“…In other Verbenaceae species, such as Aloysia polystachya, the anxiolytic and antidepressant like activity was determined 9,11,28,29,13 , and phenylethanoids glycoside and flavonoids from the hydroethanolic extract of leaves was described 28 . Additionally, phenylethanoid glycoside, particularly the main component acteoside or verbascoside was determined to have inhibitory activity of monoamine oxidase-A, and both anxiolytic and antidepressant activity have been associated to the presence of this component [28][29] .…”

Section: Discussionmentioning

confidence: 99%

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2021

IJPSR

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Anxiety disorders are among the most prevalent and high-cost diseases. Medicinal plants are a very good option to treat, and several have shown the ability to reduce anxiety. We report here the effect of A. gratissima var. gratissima (Agg) on behavior and anxiety in mice. The methanol extract of leaves was tested in order to verify the safety, effect on sleeping time and behavior. Anxiety was tested through the Open field, Hole board, and elevated plus maze tests, with 50, 100, 200, and 400 mg/kg of Agg, and diazepam as positive control drugs. The results showed that A. gratissima var. gratissima did not cause signs of toxicity or sedative effect, and the general behavior of mice was not altered with any dose. All doses of Agg and diazepam, after the mice were submitted to the Open field and Hole board, evidenced a significant increase in ambulation, and a significant decrease in immobility time, related to the control group. On Hole board, a significant increase in number and time spent in exploration indicated a possible anxiolytic-like effect, that was confirmed by the results obtained in the elevated plus-maze, where mice increased the number of entries and time spent in open arms, and decreased the number of entries and time spent in closed arms of the labyrinth. Al the results evidenced the safety of Agg, and denoted an anxiolytic-like effect in mice. INTRODUCTION:Anxiety disorders, affecting up to 33.7% of the population, are the most prevalent mental disorders and are associated with a high cost in health. A substantial underrecognition and under-treatment of these disorders have been demonstrated 1 . Persistent fretfulness, distractedness, and a sort of whole-body clenching to a full-blown panic attack constitute the variety of clinical manifestations of anxiety, which are indicators of a possible threat to homeostasis.

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Section: Discussionmentioning

confidence: 99%

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2021

IJPSR

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“…Overall the treatment with HELAp, either oral or through immersion, had an anxiolytic activity similar to the treatment with buspirone. It is worth pointing out that acteoside has a modulatory effect in the Monoamine oxidase A (MAO-A) [11]. However, Carvalho [72], in a study with rats, suggested central depressor effect to this compound.…”

Section: Discussionmentioning

confidence: 99%

“…The most representative compounds of this species are phenylethanoid and phenylpropanoid glycosides such as forsythoside A, plantainoside C, martynoside [10], and, mainly, the acteoside [10,11]. Phenylpropanoids are water-soluble polyphenols, largely found in medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

“…The acteoside, also known as verbascoside, is a water-soluble phenylpropanoid glycoside with reducing and radical scavenging ability in a hydrophobic medium (such as the membranes), acting in cell signaling and mitochondrial function [14,15,16]. Recently, it has been reported that acteoside, a molecule found in the extract of Aloysia polystachya , has inhibitory activity over the monoamine oxidase A [11].…”

Section: Introductionmentioning

confidence: 99%

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Anxiolytic and Antidepressant Effects of the Hydroethanolic Extract from the Leaves of Aloysia polystachya (Griseb.) Moldenke: A Study on Zebrafish (Danio rerio)

et al. 2019

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Medicinal plants such as Aloysia polystachya are often used in the treatment of psychiatric diseases, including anxiety- and depression-related humor disturbances. In folk medicine, A. polystachya is used to treat digestive and respiratory tract disturbances, as a sedative and antidepressant agent, and as a tonic for the nerves. This study aimed to evaluate the antidepressant and anxiolytic effect from the hydroethanolic extract from the leaves of Aloysia polystachya (HELAp) in zebrafish. The extract was analyzed through ultra-performance liquid chromatography-mass spectroscopy (UPLC-MS) and the main compound detected was acteoside. HELAp was administered orally (10 mg/kg) and through immersion (mg/L). The anxiolytic activity was evaluated through the scototaxis (light–dark) test using caffeine as an anxiogenic agent and buspirone as a positive control. The parameters assessed were: period spent in the white compartment (s), latency (s), alternations (n), erratic swims (n), period of freezing (s), thigmotaxis (s), and risk evaluation (n). The antidepressant effect was evaluated through the novel tank diving test using 1% ethanol, unpredictable chronic stress, and social isolation as depressors; fluoxetine was used as a positive control. The parameters assessed were: period spent at the top of the tank, latency, quadrants crossed, erratic swim, period of freezing, and distance of swam. The main chemical compound of HELAp was acteoside. The administration of the extract on zebrafish managed to revert the anxiogenic effect of caffeine without impairing their locomotion. Additionally, the treatment exerted antidepressant activity similarly to fluoxetine. Overall, the results suggest a significant anxiolytic and antidepressant activity to the extract, which is probably due to the presence of the major compound, acteoside.

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“…The existence of a relationship between chronic pain and depression is now widely accepted among researchers (Rojas-Corrales et al, 2003). Chronic pain and depression are two very frequent and debilitating concurrent conditions.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of pain and inflammation induced in mice treated orally with crude extract of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae)

Ortiz¹,

Wilson²,

Montalbetti³

et al. 2022

j app pharm sci

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The objective of this work was to determine the analgesic and anti-inflammatory activity of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in experimental models of acute pain and inflammation in mice. Methods of pain induced by caudal pressure (Randall-Selitto), chemical stimulation (acetic acid or the writhing test), and thermal stimulation (hot plate) were used to study analgesic effects. Additionally, edema of the paw induced by injection of 1% carrageenan was used to evaluate the anti-edema activity of A. polystachya. Oral doses of 100 and 200 mg/kg of crude extract of A. polystachya (CEAp) significantly reduced the sensibility to painful stimuli induced by the application of pressure in the tail comparable with an analgesic effect (p < 0.05) in a non-dose dependent manner. Additionally, the number of abdominal contortions was significantly reduced in comparison with the control group and with similar strength to the group treated with Indomethacin 10.0 mg/kg. Similarly, in the model of pain induced by thermal stimulation, it was observed that the groups treated with CEAp presented statistically significant analgesic activity in comparison with the control group and with a similar intensity to the group treated with morphine 6.0 mg/kg. Finally, a statistically significant reduction of edema induced by 1% carrageenan was observed with oral administration of 100 mg/kg of CEAp in comparison to the positive control of edema in a manner similar to the group treated with Indomethacin 10 mg/kg. Based on these results, it was concluded that the CEAp possesses the capacity to increase pain threshold in three pre-clinical models of pain induced (mechanical pressure, chemically and thermally) in mice, compatible with an analgesic effect. Also, CEAp demonstrated antiedematous capacity in carrageenan-induced paw edema in mice, concordant with anti-inflammatory effect using the plethysmography method. These pharmacological effects are potentially due to the presence of verbascoside in CEAp. Additionally, these experimental results are correlated with the popular use of CEAp and present a variety of opportunities for pharmaceutical research such as the development of innovative phytopharmaceuticals.

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Isolation and Identification of Phenylethanoid Glycosides from Aloysia polystachya and Its Activity as Inhibitors of Monoamine Oxidase-A

Cited by 8 publications

References 37 publications

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Anxiolytic and Antidepressant Effects of the Hydroethanolic Extract from the Leaves of Aloysia polystachya (Griseb.) Moldenke: A Study on Zebrafish (Danio rerio)

Attenuation of pain and inflammation induced in mice treated orally with crude extract of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae)

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