Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

Abstract

The in vivo determination of radical scavenging activity of flavonoids (Fls) and their metal complexes (M‐Fls) through co‐administration of 2‐hydroxypropyl beta‐cyclodextrin (HP‐βCD) was determined. The flavonoids morin (mo), quercetin (quer), primuletin (prim), their Cu (II) and Fe (III) complexes were selected to explore their radical scavenging potential. Metal complexes of flavonoids (M‐Fls) showed better radical scavenging activity RSA when injected to rats than corresponding flavonoids. The RSA is improved in the presence of HP‐βCD. This increase in RSA was assisted by enhanced enzymatic activity of catalase (CAT) and superoxide dismutase (SOD) activity. The compounds displayed hepatoprotection against alloxan induced liver damage as flavonoid injected group displayed lower levels of enzymes and intermediates aspartate/alanine transaminase (AST), alanine aminotransferase (ALT), Lipid peroxidation (MDA), Hydroxyproline (HYP), Sailic acid (SA) and higher albumin and total proteins level compared with alloxan treated group. It was evaluated by histopathological investigations that M‐Fls restored the hepatic damage caused by alloxan. The binding constants values of the compounds with human plasma (n‐HP) revealed the order of 103‐104 L−1. The binding interactions of the compounds with human plasma in the presence of HP‐βCD is decreased which in turns increased the RSA as well as CAT and SOD activities. Based upon our results, it was concluded that radical scavenging activities and hepatoprotective activities of M‐Fls is increased when co‐administrated with HP‐βCD.

Ameliorative Effect of Citrus Lemon Peel Extract and Resveratrol on Premature Ovarian Failure Rat Model: Role of iNOS/Caspase-3 Pathway

“…In agreement with these results, the present findings showed that the flavonoid compounds present in LPE such as narirutin, hesperidin, and nobiletin, have the ability to reduce the oxidative stress induced by CPA in POF rats via enhancement of antioxidant status and reduction of lipid peroxidation levels. have been several previous studies of similar findings [10,50].…”

“…The fruit contains a high concentration of phenolic chemicals, including flavonoids such as hesperidin, naringin, and naringenin and flavones such as diosmin [9]. These compounds exhibit many pharmacological actions in the body and are scientifically confirmed to confer positive health effects to limit the developing of various illness due to the abundance of vitamins, minerals, and other active ingredients related to antioxidant, anti-inflammatory, antiatherosclerotic, antiseptic, antifungal, anticarcinogenic, antimutagenic and hepatoprotective actions, and they boost the body's immune and cardiovascular system [10,11]. Citrus fruits can protect the human body from injury caused by ROS by reducing the loading of free radicals and/or enhancing the endogenous antioxidant protection system [12].…”

Effects of aqueous extract of Medicago denticulata against paracetamol‐induced hepatotoxicity in rabbits

“…The blood lipid profile has been used as an indicator for liver injury (Buness et al., 2014). The decrease in total lipids along with high values of HDL‐c due to a high dose of MD indicates an increase in the regeneration process leads to repair of hepatic and renal tissue damage induced by paracetamol (Jabeen et al., 2019). Phenolic compounds and other minerals in Medicago sativa had been reported to normalize the blood cholesterol level by reducing intestinal absorption of cholesterol and also decreases atherosclerosis (Cohen et al., 1990).…”

Application of graphene oxide in the adsorption and extraction of bioactive compounds from lemon peel

“…Moreover, a huge number of reports have been presented about the medical activities of naringin and rutin (El‐desoky et al., 2018; Gullón et al., 2017). As a result, the flavonoids have fascinated much attention of the scientists because they showed hepatoprotective activities and the therapeutic properties such as antioxidant, anti‐inflammatory, anticarcinogenic, and antiaging (Chen et al., 2020; Jabeen et al., 2019; Maleki et al., 2019; Vukovic et al., 2018). However, the peel of citrus fruits contains the abundant proportion of flavonoid as compared to other parts of the fruit.…”