Antioxidant Effects of Probiotics in Experimentally Induced Peritonitis

Erginel, Başak; Aydın, Fatih; Erginel, Turgay; Tanık, Canan; Abbasoglu, Semra; Soysal, Feryal Gün; Keskin, Erbuğ; Çelik, Alaaddin; Salman, Tansu

doi:10.1089/sur.2015.072

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…The present study, designed to evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in sepsis-induced AKI, confirmed that the experimental sepsis model has similar characteristics to those expressed in humans, resulting from trauma with perforation of intestinal loops, colitis or post-surgical peritonitis (14) . Characteristic symptoms of sepsis were observed, such as hypothermia, reduction of the average arterial pressure to values inferior to 60 mmHg, and hyperglycemia (4)(5) , reasserting the accuracy of the CLP technique in the experimental model.…”

Section: Resultssupporting

confidence: 75%

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Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

et al. 2018

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Section: Resultssupporting

confidence: 75%

“…Histological lesions, such as loss of microvilli in proximal tubules, tubular cell swelling, inflammation, necrosis and tubular regeneration, ischemic glomeruli, congestion and amorphous corticomedullary were qualitatively graded as mild (+), moderate (++), or severe (+++) (14) .…”

Section: Study Protocolmentioning

confidence: 99%

Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

et al. 2018

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“…In addition, MDA and MPO activity decreased in probiotic treated groups, while GSH increased. In addition, mucosal damage decreased in probiotic fed groups 22 .…”

Section: Discussionmentioning

confidence: 92%

Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Dalbaşı¹,

Gedik²,

Tüzün³

et al. 2020

Dicle Tıp Dergisi

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Objective: Generalized peritonitis is fairly common with very high mortality of delayed diagnosis and treatment of infectious condition. In this study, we aimed to determine the effectiveness of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and C-reactive protein (CRP) levels in peritonitis severity.Methods: This study was planned prospective and randomized. Study consisted of three groups. Each group had 50 patients. Group 1, patients with generalize peritonitis ; Group 2,patients with non-abdominal inflammatory disease; Group 3, healthy individuals as a control group. The venous blood samples from patients in group 1 and 2 were collected to determine MDA, SOD, CAT and CRP levels at the operation day. The same procedures repeated postoperative first and third day. Blood samples were collected once from group 3.One-way Anova test was used to compare average of intergroup parametric variables. Repeated Anova test was used to compare intragroup parameters.Results: Demographic features and cause of laparatomy of all groups were evaluated. MDA values of group 1 in days 0, 1st and 3rd compared with group 2 and group 3 the MDA values of group 1 were higher than group 2 and 3 (p<0,0001). CAT values of group 1 in days 0, 1st and 3rd were lower than group 2 and group 3 (p<0,0001). SOD values of group 1 and 2 in day 0 were lower than group 3 (p<0,0001). CRP values of group 1 in days 0,1st and 3rd were higher than group 2 (p<0,0001).

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“…Erginel et al [ 48 ] evaluated antioxidant mechanisms of probiotics on gut mucosa in peritonitis. Rats were treated with probiotics after CLP-induced peritonitis/5 days or before the CLP procedure and after the surgery/5 days.…”

Section: Discussionmentioning

confidence: 99%

Influence of Synbiotics on Selected Oxidative Stress Parameters

Kleniewska

Pawliczak

2017

Oxidative Medicine and Cellular Longevity

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The aim of the present study was to assess synbiotic (Lactobacillus casei + inulin) influence on oxidative stress parameters such as concentrations of malondialdehyde (MDA), hydrogen peroxide (H2O2), glutathione, and free sulfhydryl groups content. Experiments were carried out on healthy volunteers (n = 32). The subjects were divided into women group (n = 16) and men group (n = 16) and randomly assigned to synbiotic and control groups. Blood samples were collected before synbiotic supplementation and after 7 wks, at the end of the study. The administration of synbiotic resulted in a significant decrease in MDA (p < 0.01), H2O2 (p < 0.01), and GSSG concentrations (p < 0.05) as compared with the control groups and significant increase in the concentrations of GSHt (p < 0.001), GSH (p < 0.01), and -SH group content (p < 0.05) versus control. Synbiotics containing L. casei plus inulin may have positive influence on selected oxidative stress markers.

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Antioxidant Effects of Probiotics in Experimentally Induced Peritonitis

Cited by 5 publications

References 19 publications

Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Influence of Synbiotics on Selected Oxidative Stress Parameters

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