Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Dalbaşı, Erkan; Gedik, Ercan; Tüzün, Abidin; Obay, Basra Deniz

doi:10.5798/dicletip.755706

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…The C‐reactive protein is an acute phase reactant. Its value increases in correlation with the severity of inflammation 30 . Studies have found that CRP has a high sensitivity in the diagnosis of AA 31 .…”

Section: Discussionmentioning

confidence: 99%

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Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Dalbaşı

Akgül²

2021

Int J Clin Pract

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Background: Acute appendicitis (AA) is the most common cause of surgery performed for the acute abdomen. The standard treatment for AA patients has been appendectomy for more than a century. The use of broad-spectrum antibiotics, the medical treatment option has come to the fore in the treatment of uncomplicated AA. Aim: Evaluate whether white blood cell (WBC), platelet count, mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW) and Creactive protein (CRP) values of patients diagnosed with uncomplicated AA clinically, with laboratory tests and radiologically with abdominal computed tomography (CT) could be a marker for choosing medical or surgical treatment. Materials and Methods: 519 patients aged between 20 and 65 years who were diagnosed with uncomplicated AA by abdominal CT in our centre between January 2016 and January 2019 were retrospectively analysed. The presence of at least one How to cite this article: Dalbaşı E, Akgül ÖL. Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?.

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Section: Discussionmentioning

confidence: 99%

“…Its value increases in correlation with the severity of inflammation. 30 Studies have found that CRP has a high sensitivity in the diagnosis of AA. 31 These findings are compatible with our study.…”

Section: Ta B L E 2 Laboratory Parameters Of Groups F I G U R Ementioning

confidence: 99%

Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Dalbaşı

Akgül²

2021

Int J Clin Pract

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“…The C-reactive protein is an acute phase reactant. Its value increases in correlation with the severity of inflammation (31). Studies have found that CRP has a high sensitivity in the diagnosis of AA (32).…”

Section: Discussionmentioning

confidence: 99%

Are Average Platelet Volume (MPV), Red Cell Distribution Width (RDW) and Platelet Distribution Width (PDW) Guiding Markers for Acute Appendicitis Treatment Options?

Dalbaşı¹,

Akgül

2021

Preprint

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Background: Acute appendicitis (AA) is the most common cause of surgery performed for acute abdomen. The standard treatment for AA patients has been appendectomy for more than a century. use of broad-spectrum antibiotics, the medical treatment option has come to the fore in the treatment of uncomplicated AA. Aim: Evaluate whether WBC, platelet count, MPV, PDW, RDW, and C-reactive protein (CRP) values of patients diagnosed with uncomplicated AA clinically, with laboratory tests and radiologically with abdominal CT could be a marker for choosing medical or surgical treatment. Material and Method: 519 patients aged between 20 and 65 years who were diagnosed with uncomplicated AA by abdominal CT in our centre between January 2016 and January 2019 were retrospectively analysed. . The presence of at least one of the criteria of 7 mm or more appendix diameter and oedema or fluid accumulation around the appendix was accepted as uncomplicated AA. After the diagnosis of AA, 223 patients were treated medically, while 296 patients underwent laparoscopic appendectomy. The first group included patients who were treated medically and the second group included patients who underwent laparoscopic appendectomy. Results: Group 2 patients had higher mean platelet count (p <.005) and RDW (p = .003) values compared to Group 1 patients, while mean PDW (p <.001) values were lower compared to those of Group 1 patients. The differences between the mean WBC, CRP and MPV values of the groups were not statistically significant (p>0.05). Conclusions: The standard treatment for acute appendicitis is surgery. Recently, studies supporting antibiotic therapy have been conducted in patients diagnosed with AA. As a result, we think that PDW, RDW, and platelet values in patients diagnosed with uncomplicated AA may be a guide in choosing patients to be treated with surgery or antibiotics. Key Words: acute appendicitis, laparoscopic appendectomy, antibiotic therapy.

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“…When there is an increase in the generation of ROMs or when antioxidant defense mechanisms decrease, the shift in the oxidant/antioxidant balance cause oxidative injury that may produce derangements of cell metabolism including peroxidation of lipids resulting in cell injury and death 4 . Malondialdehyde (MDA), the final product of lipid peroxidation induced by ROMs, leads to crosslinking in lipids, proteins and nucleic acids, and is considered an important marker of oxidative stress 4,5 .…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between IgA Vasculitis and Antioxidant Activity In Children

Temel

2021

Dicle Tıp Dergisi

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Objective: Immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis seen in children. The aim of this study is to investigate the relationship between malondialdehyde-induced oxidative stress, antioxidant system and organ involvement in IgAV patients.Method: 32 patients and 28 healthy children were included in the study. Serum malondialdehyde, reduced glutathione, vitamin E, vitamin C, retinol, and beta-carotene levels were measured in patients (separately in both the active and remission phases) and healthy children.Results: MDA levels were significantly higher in patients with active phase while reduced glutathione and vitamin C levels were markedly lower in both the active and the remission phases. Retinol and beta-carotene levels were lower in the active phase. It was found that retinol levels were significantly lower in patients with gastrointestinal system involvement compared to those without. Vitamin C levels were significantly lower in those with kidney involvement compared to those without. Also, a negative correlation was observed between retinol levels and the number of organs involved. Conclusion:We consider that especially vitamin C and vitamin A may be used in the treatment of IgAV. However, whether the derangements of the oxidant/antioxidant balance in the direction of increased oxidative stress are consequences or causes of the events occurring in the active phase of IgAV are open to further investigation.

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Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Cited by 5 publications

References 17 publications

Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Are Average Platelet Volume (MPV), Red Cell Distribution Width (RDW) and Platelet Distribution Width (PDW) Guiding Markers for Acute Appendicitis Treatment Options?

The Relationship Between IgA Vasculitis and Antioxidant Activity In Children

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