Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Abstract

Background: Acute appendicitis (AA) is the most common cause of surgery performed for the acute abdomen. The standard treatment for AA patients has been appendectomy for more than a century. The use of broad-spectrum antibiotics, the medical treatment option has come to the fore in the treatment of uncomplicated AA. Aim: Evaluate whether white blood cell (WBC), platelet count, mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW) and Creactive protein (CRP) values of patients diagnosed with uncomplicated AA clinically, with laboratory tests and radiologically with abdominal computed tomography (CT) could be a marker for choosing medical or surgical treatment. Materials and Methods: 519 patients aged between 20 and 65 years who were diagnosed with uncomplicated AA by abdominal CT in our centre between January 2016 and January 2019 were retrospectively analysed. The presence of at least one How to cite this article: Dalbaşı E, Akgül ÖL. Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?.

Omega-3 index is directly associated with a healthy red blood cell distribution width

“…can suppress RBC maturation in bone marrow, and larger immature RBCs, i.e. reticulocytes, enter the circulation and increase the RDW [16]. This relationship between RDW and inflammation may partially explain the relationship of higher RDW with risk of cardiovascular disease and mortality [10,11,14,30,32,57].…”

“…In recent years, RDW has been found to be a predictor of multiple adverse health outcomes unrelated to anemia, including increased risk for death from cardiovascular disease [6][7][8][9][10][11][12], SARS-CoV-2 [13][14][15], sepsis [16,17], lung disease [18], and cancer [19,20]. Like all cell membranes, RBC membranes are a complex lipid bilayer [21].…”

Omega-3 Index is Directly Associated with a Healthy Red Blood Cell Distribution Width

“…can suppress RBC maturation in bone marrow, and larger immature RBCs, i.e. reticulocytes, enter the circulation and increase the RDW [16]. This relationship between RDW and inflammation may partially explain the relationship of higher RDW with risk of cardiovascular disease and mortality [10,11,14,30,32,57].…”

“…In recent years, RDW has been found to be a predictor of multiple adverse health outcomes unrelated to anemia, including increased risk for death from cardiovascular disease [6][7][8][9][10][11][12], SARS-CoV-2 [13][14][15], sepsis [16,17], lung disease [18], and cancer [19,20]. Like all cell membranes, RBC membranes are a complex lipid bilayer composed of glycerolipids, sphingomyelin and cholesterol [21].…”