Omega-3 Index is Directly Associated with a Healthy Red Blood Cell Distribution Width

McBurney, Michael I.; Tintle, Nathan L.; Harris, William S.

doi:10.1101/2021.10.22.21264652

Cited by 2 publications

(2 citation statements)

References 69 publications

(93 reference statements)

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“…4 , 27 , 28 In healthy adults, the omega-3 index, also known to affect membrane fluidity and deformability, was found to be inversely associated with RDW. 29 Furthermore, RDW may be inversely associated with fractional flow reserve independent of the severity of a coronary stenosis, also implying an adverse effect on microvascular function. 30…”

Section: Article In Pressmentioning

confidence: 99%

Relation of red blood cell distribution width to risk of major adverse cardiovascular events, death, and effect of alirocumab after acute coronary syndromes

Moriarty

Steg

McGinniss

et al. 2022

Journal of Clinical Lipidology

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Section: Article In Pressmentioning

confidence: 99%

Relation of red blood cell distribution width to risk of major adverse cardiovascular events, death, and effect of alirocumab after acute coronary syndromes

Moriarty

Steg

McGinniss

et al. 2022

Journal of Clinical Lipidology

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“…The omega-3 index (OM3I), a metric expressing the RBC EPA + DHA content as a mole percent of total fatty acids, is a validated diet-sensitive biomarker of omega-3 fatty status (12,17). The OM3I is reported to be inversely correlated to cardiovascular risk and inflammatory status (18), and directly associated with healthy RBC morphology (19). Therapeutic OM3I cut points of <4, 4-8, and >8 have been established to indicate high, moderate and low CVD risk, respectively (12,20).…”

Section: Introductionmentioning

confidence: 99%

The Omega-3 Index Response to an 8 Week Randomized Intervention Containing Three Fatty Fish Meals Per Week Is Influenced by Adiposity in Overweight to Obese Women

et al. 2022

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BackgroundThe Dietary Guidelines for Americans (DGA) recommends consuming ~225 g/wk of a variety of seafood providing >1.75 g/wk of long-chain omega-3 fatty acids to reduce cardiovascular disease risk, however individual responses to treatment vary.ObjectiveThis study had three main objectives. First, to determine if a DGA-conforming diet (DGAD), in comparison to a typical American diet (TAD), can increase the omega-3 index (OM3I), i.e., the red blood cell mol% of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA). Second, to identify factors explaining variability in the OM3I response to dietary treatment. Third to identify factors associated with the baseline OM3I.DesignThis is a secondary analysis of a randomized, double-blind 8 wk dietary intervention of overweight/obese women fed an 8d rotating TAD (n = 20) or DGAD (n = 22) registered at www.clinicaltrials.gov as NCT02298725. The DGAD-group consumed 240 g/wk of Atlantic farmed salmon and albacore tuna in three meals with an estimated EPA + DHA of 3.7 ± 0.6 g/wk. The TAD-group consumed ~160 g/wk of farmed white shrimp and a seafood salad containing imitation crab in three meal with an estimated EPA + DHA of 0.45 ± 0.05 g/wk. Habitual diet was determined at baseline, and body composition was determined at 0 and 8wks. Red blood cell fatty acids were measured at 0, 2 and 8 wk.ResultsAt 8 wk, the TAD-group OM3I was unchanged (5.90 ± 1.35–5.80 ± 0.76%), while the DGAD-group OM3I increased (5.63 ± 1.27–7.33 ± 1.36%; p < 0.001). In the DGAD-group 9 of 22 participants achieved an OM3I >8%. Together, body composition and the baseline OM3I explained 83% of the response to treatment variability. Baseline OM3I (5.8 ± 1.3%; n = 42) was negatively correlated to the android fat mass (p = 0.0007) and positively correlated to the FFQ estimated habitual (EPA+DHA) when expressed as a ratio to total dietary fat (p = 0.006).ConclusionsAn 8 wk TAD did not change the OM3I of ~6%, while a DGAD with 240 g/wk of salmon and albacore tuna increased the OM3I. Body fat distribution and basal omega-3 status are primary factors influencing the OM3I response to dietary intake in overweight/obese women.

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Omega-3 Index is Directly Associated with a Healthy Red Blood Cell Distribution Width

Cited by 2 publications

References 69 publications

Relation of red blood cell distribution width to risk of major adverse cardiovascular events, death, and effect of alirocumab after acute coronary syndromes

Relation of red blood cell distribution width to risk of major adverse cardiovascular events, death, and effect of alirocumab after acute coronary syndromes

The Omega-3 Index Response to an 8 Week Randomized Intervention Containing Three Fatty Fish Meals Per Week Is Influenced by Adiposity in Overweight to Obese Women

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