Relation of red blood cell distribution width to risk of major adverse cardiovascular events, death, and effect of alirocumab after acute coronary syndromes

Moriarty, Patrick M.; Steg, Philippe Gabríel; McGinniss, Jennifer; Zeiher, Andreas M.; White, Harvey D.; Manvelian, Garen; Pordy, Robert; Loy, Megan; Jukema, J. Wouter; Harrington, Robert A.; Gray, Jessica V.; Gorby, Lauryn K.; Goodman, Shaun G.; Dı́az, Rafael; Bittner, Vera; Bhatt, Deepak L.; Szarek, Michael; Schwartz, Gregory G.

doi:10.1016/j.jacl.2022.08.004

Cited by 2 publications

(3 citation statements)

References 35 publications

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“…In one of these studies, similar to the current one, the association between increased RDW value and increased NT-proBNP was confirmed [33]. Interestingly, subanalysis from the ODYSSEY OUTCOMES study showed that despite heavy treatment of dyslipidaemia with alirocumab, RDW remained an independent predictor of MACE after acute coronary syndrome [36].…”

Section: Discussionsupporting

confidence: 80%

The predictive value of complete blood count-derived indices for major adverse cardiovascular events in MINOCA patients at 5-year follow-up

Buller¹,

Witkowski

Tyczyński

et al. 2023

Medical Research Journal

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Introduction:The authors analysed the potential of red blood cell and platelet indices such as red cell distribution width (RDW), mean corpuscular volume (MCV), and mean platelet volume (MPV) as predicting factors in myocardial infarction with non-obstructive coronary arteries (MINOCA) patients of 5-year outcomes.Material and methods: Between 2010-2015 were identified 112 patients who had final MINOCA diagnosis and available laboratory findings. The primary endpoint was the 5-year major adverse cardiovascular events rate, defined as cardiac death, myocardial infarction, or hospitalization due to angina.Results: Only RDW had a significant impact on long-term outcomes. 93 (83%) patients had RDW ≤ 14.5 (group 1), and 19 (17%) patients had RDW > 14.5 (group 2). The mean RDW value was 13.58 ± 1.11%. In group 1 and group 2, mean RDW values were 13.18 ± 0.55%, and 15.54 ± 1.06% (p < 0.001), respectively.Patients with abnormal RDW values (group 2) characterized lower value of left ventricular eject fraction (60 ± 8% vs. 53 ± 13%, p = 0.024), and higher 170 ± 5,285 pg/mL vs. 6,200 ± 4,223 pg/mL, p = 0.013) as well as troponin levels (501-2500 ng/mL: 31% vs. 53%, p = 0.02). A statistically significant difference was observed only for all-cause death. All-cause death rates for no RDW ≤ 14.5% vs. RDW > 14.5% were 2.2% vs. 21.1% (HR 5.09, 95% CI 1.03-25.2, p = 0.046), respectively.Conclusions: RDW was significantly associated with the increased risk of all-cause mortality in MINOCA patients at 5 years.

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Section: Discussionsupporting

confidence: 80%

The predictive value of complete blood count-derived indices for major adverse cardiovascular events in MINOCA patients at 5-year follow-up

Buller¹,

Witkowski

Tyczyński

et al. 2023

Medical Research Journal

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show abstract

“…reticulocytes, enter the circulation and increase the RDW [16]. This relationship between RDW and inflammation may partially explain the relationship of higher RDW with risk of cardiovascular disease and mortality [10,11,14,30,32,57]. Similarly, lower omega-3 fatty acid levels are associated with a heightened inflammatory state [58][59][60], and omega-3 supplementation lowers inflammatory mediators [61].…”

Section: Increases In Membrane Dha (A Highly Flexible Molecule) Influ...mentioning

confidence: 99%

“…The O3I is a stable biomarker of long term EPA and DHA intake [24,29]. Since both a low O3I [30] and an elevated RDW [7,31,32] are known to be associated with risk for earlier all-cause mortality (Supplemental Table 1), the aim of this cross-sectional analysis was to determine if there was an inverse relationship between the O3I and RDW in healthy adults without evidence of inflammation or tissue injury. If there was, then the former may play a role in maintaining a healthy distribution of RBC sizes in adults.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 index is directly associated with a healthy red blood cell distribution width

McBurney

Tintle

Harris

2022

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Relation of red blood cell distribution width to risk of major adverse cardiovascular events, death, and effect of alirocumab after acute coronary syndromes

Cited by 2 publications

References 35 publications

The predictive value of complete blood count-derived indices for major adverse cardiovascular events in MINOCA patients at 5-year follow-up

The predictive value of complete blood count-derived indices for major adverse cardiovascular events in MINOCA patients at 5-year follow-up

Omega-3 index is directly associated with a healthy red blood cell distribution width

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