Antioxidant and Whitening Effects of Sorbus commixta HEDL Cortex Extract

Kim, Tae-Hyuk; You, Jin-Kyoun; Kim, Jeong-Mi; Baek, Jongmi; Kim, Hyun‐Sook; Park, Jeong-Hae; Choe, Myeon

doi:10.3746/jkfn.2010.39.10.1418

Cited by 11 publications

(3 citation statements)

References 16 publications

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“…또한 미백제로 사용되고 있는 arbutin의 양성대조군과 홍화자 추출물 을 50 µg/mL 농도에서 비교한 결과, 홍화자 추출물이 MITF, tyrosinase, TRP-1, TRP-2의 mRNA 발현을 효과적으로 억제하는 것을 확인하였다. 본 결과와 유사한 연구에서 신선초 추출물은 endothelin-1 mRNA와 단백질 생성량을 감소시킴으로써 melanin 생성량을 감소시킨다고 보고하였고(34), 정공피 추출물 역시 melanin 형성에 관여하는 tyrosinase, TRP-1, TRP-2 유전자 발현을 억제함 으로써 미백 작용을 하는 것으로 보고 하였다(35). 이상의 결과, 홍화자 추출물은 tyrosinase 활성과 melanin 합성 억제효과를 갖 고 있으며, 이러한 효과는 MITF 발현 억제를 통한 tyrosinase, TRP-1, TRP-2의 발현 감소를 규명하였다.…”

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A Study on the Depigmenting Effect of Carthamus tinctorius Seed, Cyperus rotundus and Schizonepeta tenuifolia Extracts

Hwang¹,

Kim²,

Hwang³

et al. 2012

Korean Journal of Food Science and Technology

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The objective of the present study was to evaluate the skin depigmentation effect of the extracts of three herbs, Carthamus tinctorius seed, Cyperus rotundus and Schizonepeta tenuifolia. Their effects on tyrosinase and melanin synthesis inhibitory action were assessed. We found that the C. tinctorius seed ethanol extracts reduced the tyrosinase activity and melanin formation of B16F10 melanoma cells. The C. tinctorius seed suppressed the expression in microphthalmia associated transcription factor (MITF), tyrosinase, tyrosinase related protein 1 (TRP-1), and tyrosinase related protein 2 (TRP-2) in B16F10 melanoma cells. These results show that C. tinctorius seed inhibited melanogenesis on the B16F10 melanoma cell. The underlying mechanism of C. tinctorius seed whitening activity may be the inhibition of tyrisinase, MITF, tyrosinase, TRP-1, and TRP-2 expression. The results suggested that C. tinctorius seed has considerable potential as a natural functional ingredient with a depigmentation effect.

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A Study on the Depigmenting Effect of Carthamus tinctorius Seed, Cyperus rotundus and Schizonepeta tenuifolia Extracts

Hwang¹,

Kim²,

Hwang³

et al. 2012

Korean Journal of Food Science and Technology

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“…This plant has been considered valuable for centuries to treat diseases including asthma, cough, dropsy, bronchitis and other bronchial disorders . In addition, previous studies have indicated that S. commixta extract exerts various biological effects such as antioxidant , whitening , anticancer and anti‐inflammatory activity . That said, few reports have attributed these biological activities to active components in S. commixta .…”

Section: Introductionmentioning

confidence: 99%

Suppression of Ultraviolet B‐mediated Matrix Metalloproteinase Generation by Sorbus commixta Twig Extract in Human Dermal Fibroblasts

Xuan

Park

Jeong

et al. 2018

Photochem & Photobiology

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Sorbus commixta is a traditional oriental medicinal plant that grows in East Asian countries such as Korea, Japan and China. The twig of S. commixta has been considered valuable for centuries to treat diseases including asthma, cough and other bronchial disorders. However, the effect of S. commixta twig extract on human skin has not been investigated well. The present study aimed at assessing the antiphotoaging effect of S. commixta twig ethanol extract (STE) on ultraviolet B (UVB)-induced matrix metalloproteinase (MMP) levels and its underlying mechanism in human dermal fibroblasts. In this study, we found that STE (12.5-50 μg mL ) treatment significantly inhibited UVB-induced MMP-1, MMP-2 and MMP-3 expression, concomitant with a downregulation of intracellular ROS generation. These effects might be associated with a STE-induced inhibition of the mitogen-activated protein kinase (MAPK) pathway. Furthermore, STE also downregulated UVB-induced c-Fos expression in a concentration-dependent manner, but had no inhibitory effect on c-Jun phosphorylation. Taken together, these results indicate that STE may be an antiphotoaging agent and that its effect may occur via its inhibition of MMPs expression and MAPK pathway activation.

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“…현재까지 마가목에 대한 연구는 주로 마가자에 집중되어 있으며, 마가자로부터 sorbic acid [17], chalcone glycoside [2], lupeol 및 lupenone [23]의 분리, 항산화 활성 [6,11,14,20], 피부 광노화 억제 효과 [1], pancreatic lipase 저해 [19], hyaluronidase 저해 [6] 및 angiotensin converting enzyme 저해 [5], 혈관이완 활성 [9,31], 지질대사 개선 [7] 및 동맥 아테롬 발생억 제 [26], 항염증 활성 [10,15,32], 알코올 손상에 의한 간보호 효과 [18], 연골손상 억제 활성 [21], 암세포 생육억제 활성 [16] 및 살초활성 [12] (Table 5). …”

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In-vitro Antithrombosis Activity of Different Parts of Sorbus commixta from Ulleung Island

김미선¹,

성화정²,

손호용

2016

Journal of Life Science

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Sorbus commixta, a flowering plant in the Rosaceae family, is native to Japan and Ulleung Island, Korea. This plant is also called maga-mok or mai-mok in Korea because the bud of the stem has a similar shape to the teeth of a horse. In this study, hot water extracts from different parts of S. commixta, such as leaf, stem, and immature and mature fruits, were prepared, and their antithrombosis and antioxidant activities were evaluated. The extraction yield and pH of stem extracts were 3.99% and 5.5, respectively. The stem extracts contained 89.2 mg/g of total polyphenols and 28.3 mg/g of total flavonoids. The hot water extracts prepared from the leaf, stem, immature, and mature fruit of S. commixta exhibited no hemolytic activity against human red blood cells, up to a concentration of 0.5 mg/ml. In an anticoagulation assay, the stem extracts showed strong extension in thrombin, prothrombin, and activated partial thromboplastin times, whereas the other extracts had no anticoagulation activity. In a platelet aggregation inhibitory activity assay, all the extracts tested had no inhibitory activity against human platelets. With regard to antioxidation activity, the stem extracts showed stronger radical scavenging activity and reducing power activity than the other extracts. The calculated RC50s, the concentration required for 50% radical scavenging activity, for DPPH anions, ABTS cations, and nitrite of the crude stem extracts were 119.7, 53.3, and 117.5 μg/ml, respectively, whereas they were 13.7, 5.2, and 14.9 μg/ml for DPPH anions, ABTS cations, and nitrite, respectively, for vitamin C. The results suggest that the stem extracts of S. commixta have strong potential for use as a novel resource for antithrombosis agents.Key words : Anticoagulation, anti-platelet aggregation, Sorbus commixta, stem extracts, Ulleungdo *Corresponding author *Tel : +82-54-820-5491, Fax : +82-54-820-7804 *E-mail : hysohn@anu.ac.kr This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Antioxidant and Whitening Effects of Sorbus commixta HEDL Cortex Extract

Cited by 11 publications

References 16 publications

A Study on the Depigmenting Effect of Carthamus tinctorius Seed, Cyperus rotundus and Schizonepeta tenuifolia Extracts

A Study on the Depigmenting Effect of Carthamus tinctorius Seed, Cyperus rotundus and Schizonepeta tenuifolia Extracts

Suppression of Ultraviolet B‐mediated Matrix Metalloproteinase Generation by Sorbus commixta Twig Extract in Human Dermal Fibroblasts

In-vitro Antithrombosis Activity of Different Parts of Sorbus commixta from Ulleung Island

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