A Study on the Depigmenting Effect of Carthamus tinctorius Seed, Cyperus rotundus and Schizonepeta tenuifolia Extracts

Abstract

The objective of the present study was to evaluate the skin depigmentation effect of the extracts of three herbs, Carthamus tinctorius seed, Cyperus rotundus and Schizonepeta tenuifolia. Their effects on tyrosinase and melanin synthesis inhibitory action were assessed. We found that the C. tinctorius seed ethanol extracts reduced the tyrosinase activity and melanin formation of B16F10 melanoma cells. The C. tinctorius seed suppressed the expression in microphthalmia associated transcription factor (MITF), tyrosinase, tyrosinase related protein 1 (TRP-1), and tyrosinase related protein 2 (TRP-2) in B16F10 melanoma cells. These results show that C. tinctorius seed inhibited melanogenesis on the B16F10 melanoma cell. The underlying mechanism of C. tinctorius seed whitening activity may be the inhibition of tyrisinase, MITF, tyrosinase, TRP-1, and TRP-2 expression. The results suggested that C. tinctorius seed has considerable potential as a natural functional ingredient with a depigmentation effect.

Topical Cyperus rotundus essential oil for treatment of axillary hyperpigmentation: a randomized, double‐blind, active‐ and placebo‐controlled study

“…Therefore, in the current study we also assessed how inflammation (manifesting as erythema) changed during treatment, and found that, unlike HQ, CREO was also able to reduce erythema. These results support the hypothesis that axillary hyperpigmentation is a type of postinflammatory hyperpigmentation, with constant irritation from hair removal, 25,29 washing, 25 tight clothing 26 and antiperspirant use 27 among the triggering variables.…”

“…In the current study, both of the active therapies were more efficacious than placebo in treating axillary pigmentation, and topical CREO was just as effective as HQ. The whitening action of CREO can be explained by its ability to inhibit expression of microphthalmia‐associated transcription factor, tyrosinase, tyrosinase‐related protein (TRP)‐1 and TRP‐2 26 . C. rotundus has also been reported to inhibit melanogenesis in B16F10 melanoma cells 26 …”

“…The whitening action of CREO can be explained by its ability to inhibit expression of microphthalmia‐associated transcription factor, tyrosinase, tyrosinase‐related protein (TRP)‐1 and TRP‐2 26 . C. rotundus has also been reported to inhibit melanogenesis in B16F10 melanoma cells 26 …”

Whitening Effect of Extracts and Fractions from Diospyros kaki calyx

“…따라서 최근에는 세포 에 영향을 미치지 않으며 멜라닌 합성을 감소시키는 천연 미 백제에 대한 연구가 활발히 진행 중이다. 천연물을 원료로 한 미백 기능성 소재로는 신선초 [23], 마황 [32], 백출 [5], 찔레 [7], 복분자 [21] [10]. 감꼭지 추출물과 분획물에 의한 멜라노마 세포의 생존율 을 확인한 결과 (Fig.…”

Whitening Effect of Biochanin A

“…그 중 cAMP/PKA 경로가 melanin 합성의 주요 경로로서 UV에 피부가 노출되었을 때 melanin 세포의 cAMP가 증가되고 하류 신호전달 물질인 PKA를 활성화시키 며, cAMP response element binding protein (CREB)을 거쳐 MITF의 발현을 증가시킨다 [4,5,6]. MITF는 melanin 합성 과정에서 중요한 전사 조절 인자로 Tyrosinase, TRP-1, TRP-2의 전사를 촉진한다 [7].…”