Antioxidant and tyrosinase inhibition activities of and #945;- mangostin and Garcinia mangostana Linn. pericarp extracts

Hassan, Wan Nur Atiqah Wan; Zulkifli, Razauden Mohamed; Basar, Norazah; Ahmad, Farediah; Yunus, Mohd Azizi Che

doi:10.7324/japs.2015.50907

Cited by 7 publications

(8 citation statements)

References 19 publications

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“…Previously, α-mangostin was also proved that can down-regulate the mushroom tyrosinase activity by in vitro. assay [ 21 ]. Many similar studies about natural extracts or compounds have shown that they directly inhibit the catalytic activity of tyrosinase by regulating the molecular structure, but cell lysate included not only tyrosinase but also TRP-1 and TRP-2.…”

Section: Discussionmentioning

confidence: 99%

α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway

Zhou

Yotsumoto

Tian

et al. 2021

Biochemistry and Biophysics Reports

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Mangosteen (Garcinia mangostana L) fruit contains many xanthones in its pericarp, such as α-mangostin. Here, we aimed to elucidate the physiological effect of α-mangostin and the mechanism on melanogenesis in mouse B16F10 cells. The melanin production in B16F10 cells was decreased by α-mangostin treatment. α-Mangostin also suppressed the enzymatic activity of tyrosinase, the critical enzyme for melanin synthesis. Furthermore, Western blot analysis revealed that α-mangostin down-regulated the protein quantity of tyrosinase, tyrosinase relative protein (TRP)-2, and microphthalmia-associated transcription factor (MITF). We also used inhibitors of the extracellular signal-regulated kinase (ERK), and glycogen synthase kinase 3 (GSK-3β) to identify the upstream signaling cascade of MITF. Results showed us GSK3β plays a more important role in α-mangostin regulated melanogenesis. Further, the de-pigmentation effect on normal human epidermal melanocytes (NHEMs) of α-mangostin was also confirmed. These results suggested that α-mangostin is a reagent for depigmentation and it has the potential to be applied as a component of cosmetics or pharmaceuticals for the therapy of spots, chloasma, or melanosis.

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Section: Discussionmentioning

confidence: 99%

α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway

Zhou

Yotsumoto

Tian

et al. 2021

Biochemistry and Biophysics Reports

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“…0.5% (w/w) mangosteen nanoparticle loaded gel and 1% clindamycin gel did not significantly improve PIH. Even if the mangosteen fruit rind extract exhibited potent anti‐inflammatory and antioxidant properties, alpha‐mangostin was previously reported to promote tyrosinase inhibition effect . PIH occurred from the overproduction of melanin by melanocytes following the late stage of inflammation and other factors, such as sun exposure which might require longer duration of MNLG treatment.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild‐to‐moderate acne vulgaris: A 12‐week, split‐face, double‐blinded, randomized, controlled trial

Lueangarun

Sriviriyakul

Tempark

et al. 2019

J of Cosmetic Dermatology

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Background: Acne vulgaris is the most common inflammatory sebaceous gland disorder in young adults. The resistant strains of Propionibacterium acnes (P. acnes) are of increasing concern in the treatment of acne. Objectives:To evaluate the efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel (containing alpha-mangostin) compared with 1% clindamycin gel for treatment of mild-to-moderate acne vulgaris.Methods: Patients aged 18-40 years were enrolled in this double-blinded, split-face, randomized, control study. The 2.5% benzoyl peroxide cream was applied to both sides of the faces once daily for 5 minutes and washed off. Each patient was randomly treated with the mangosteen fruit rind extract on one side and 1% clindamycin on another side of the face twice daily for 12 weeks. Treatment efficacies and side effects were evaluated on every follow-up.Results: Twenty-eight patients, 24 female (85.7%), mean ± SD age of 25.14 ± 5.8, with Global Acne Grading system (GAGs) score of 15.43 ± 5.96 were included.Mangosteen fruit rind extract significantly showed significant 66.86% and 67.05% reduction of comedone and inflammatory lesions (P < 0.001) after 12-week treatment. The improvement on both treated sides significantly showed since 2 weeks after treatment, without statistical difference between two groups. Nonetheless, the mangosteen fruit rind extract revealed significantly better improvement of clinical severity, with no severe side effects. Conclusions:The mangosteen fruit rind extract formation could be a phytopharmaceutical medication for effective treatment of mild and moderate acne vulgaris treatment comparable to 1% clindamycin gel, with no severe side effects. K E Y W O R D Sacne vulgaris, alpha-mangostin, mangosteen fruit rind extract, nanoparticle, phytochemicals, randomized controlled trial

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“…Other studies also revealed that -keto group in mangosteen peel have a structure such as dihydroxyphenylalanine (DOPA) or tyrosine that could prevent melanogenesis in skin-induced UVB radiation [15], [16]. Physical and chemical characterization of mangosteen peel has been already reported by previous studies [11], [12], [13], [14], [15], [16]; however, the potency of the mangosteen peel extract-based cream and its mechanism in skin hyperpigmentation is still unknown.…”

Section: Introductionmentioning

confidence: 95%

“…possesses antioxidant, anticancer, anti-inflammatory, and antibacterial activity [11]. α-mMangostin, the primary constituent of xanthones in mangosteen peel has potency as an anti-tyrosinase for treating issues of skin hyperpigmentation [12]. The previous studies reported that the mangosteen peel contains phenolic and flavonoid polyphenols, both of which include phenol rings with one or more hydroxyl substituents that may scavenge ROS as a result of exposure to UVB radiation [13], [14].…”

Section: Introductionmentioning

confidence: 99%

The Mangosteen Peel Ethyl Acetate Extract-based Cream Inhibits Ultraviolet-B Radiation-induced Hyperpigmentation in Guinea Pig Skin

Harlisa¹,

Kariosentono

Purwanto

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Ultraviolet B (UVB) radiation is the main factor causing the aberrant melanin pigments leading to skin hyperpigmentation. Retinoic acid and hydroquinone are the primary preference for the skin whitening agents in preventing hyperpigmentation. However, these treatments could induce slight-to-severe irritation leading to skin cancer. Mangosteen peel possesses α-mangostin, the primary constituent of xanthones in mangosteen peel that has potency as an anti-tyrosinase for treating issues of skin hyperpigmentation. AIM: This study aims to demonstrate the capacity of mangosteen peel ethyl acetate extract-based cream in inhibiting the UVB radiation-induced skin hyperpigmentation in guinea pig. MATERIALS AND METHODS: A total of 25 female guinea pigs were used to produce UVB-irradiated skin hyperpigmentation model. Guinea pig skins were treated with 12% mangosteen ethyl acetate extract-based cream. Mushroom tyrosinase inhibitor activity was used to evaluate the capacity of mangosteen extract in inhibiting tyrosinase activity in vitro. The melanin index in guinea pig skin after treatments was analyzed using a mexameter. The percentage of epidermal melanin-contained keratinocytes of skin tissues were analyzed using masson fontana. Pmel17 expression in cell surface was determined using immunohistochemistry. The level of tyrosinase in tissue homogenates was analyzed using Enzyme-linked immunosorbent assays. RESULTS: Mangosteen peel ethyl acetate extract showed potent inhibitory activity against the mushroom tyrosinase. Its-based cream decreased melanin index, epidermal melanin, Pmel17 expression, and tyrosinase level in hyperpigmentation skin tissues. CONCLUSION: Overall, our study demonstrates the capacity of mangosteen peel ethyl acetate extract-based cream in inhibiting the UVB radiation-induced skin hyperpigmentation in guinea pig.

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Antioxidant and tyrosinase inhibition activities of and #945;- mangostin and Garcinia mangostana Linn. pericarp extracts

Cited by 7 publications

References 19 publications

α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway

α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway

Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild‐to‐moderate acne vulgaris: A 12‐week, split‐face, double‐blinded, randomized, controlled trial

The Mangosteen Peel Ethyl Acetate Extract-based Cream Inhibits Ultraviolet-B Radiation-induced Hyperpigmentation in Guinea Pig Skin

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