Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild‐to‐moderate acne vulgaris: A 12‐week, split‐face, double‐blinded, randomized, controlled trial

Abstract

Background: Acne vulgaris is the most common inflammatory sebaceous gland disorder in young adults. The resistant strains of Propionibacterium acnes (P. acnes) are of increasing concern in the treatment of acne. Objectives:To evaluate the efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel (containing alpha-mangostin) compared with 1% clindamycin gel for treatment of mild-to-moderate acne vulgaris.Methods: Patients aged 18-40 years were enrolled in this double-blinded, split-face, randomized, control study. The 2.5% benzoyl peroxide cream was applied to both sides of the faces once daily for 5 minutes and washed off. Each patient was randomly treated with the mangosteen fruit rind extract on one side and 1% clindamycin on another side of the face twice daily for 12 weeks. Treatment efficacies and side effects were evaluated on every follow-up.Results: Twenty-eight patients, 24 female (85.7%), mean ± SD age of 25.14 ± 5.8, with Global Acne Grading system (GAGs) score of 15.43 ± 5.96 were included.Mangosteen fruit rind extract significantly showed significant 66.86% and 67.05% reduction of comedone and inflammatory lesions (P < 0.001) after 12-week treatment. The improvement on both treated sides significantly showed since 2 weeks after treatment, without statistical difference between two groups. Nonetheless, the mangosteen fruit rind extract revealed significantly better improvement of clinical severity, with no severe side effects. Conclusions:The mangosteen fruit rind extract formation could be a phytopharmaceutical medication for effective treatment of mild and moderate acne vulgaris treatment comparable to 1% clindamycin gel, with no severe side effects. K E Y W O R D Sacne vulgaris, alpha-mangostin, mangosteen fruit rind extract, nanoparticle, phytochemicals, randomized controlled trial

The Role of Herbal Medicine in the Treatment of Acne Vulgaris: A Systematic Review of Clinical Trials

“…All herbal medicines, G. mangostana , M. communis , and the combination of A. cepa , Lavandula , G. mangostana , A. vera , M. papyrifera , and M. alternifolia significantly reduced ( p < 0.001; p < 0.0001; p =0.003, respectively) the concentration of porphyrins, in relation to the beginning of the study, thus demonstrating their antibacterial properties [ 48 , 53 , 63 ]. Additionally, the efficacy of G. mangostana and the herbal combination was compared with that of clindamycin and benzoyl peroxide, respectively.…”

“…Additionally, the efficacy of G. mangostana and the herbal combination was compared with that of clindamycin and benzoyl peroxide, respectively. In both studies, the difference between the changes observed in the intervention group and in the control group was not statistically significant ( p =0.649 and p =0.425) [ 48 , 63 ].…”

“…Finally, in the study by Lueangarun et al, G. mangostana promoted the regression of acne more markedly than clindamycin. The difference between the two groups was statistically significant ( p =0.004) [ 48 ].…”

Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials

“…The controls used were clindamycin (1%) and a placebo gel base, respectively. The nanodrugs showed significant reduction of comedones and inflammatory lesions and significant improvement in acne vulgaris with no severe side effects or skin irritation (Lueangarun, Sriviriyakul, Tempark, Managit, & Sithisarn, 2019; Pan‐In, Wongsomboon, Kokpol, Chaichanawongsaroj, & Wanichwecharungruang, 2015). This also supports the favorable use of these nanodrugs over common acne treatments, which can result in several side effects (Tripathi, Gustafson, Huang, & Feldman, 2013).…”

“…Mild adverse events reported include stomachache (Asadi et al., 2019; Asadi, Gholami, Siassi, Qorbani et al., 2019) and nausea (Jazayeri‐Tehrani et al., 2019). The remaining studies reported multiple events with one study reporting flatulence, dyspepsia, headache, increased appetite, nausea, and yellow stool (Masoodi et al., 2018), while another reported minimal irritation, dryness, and itching (Lueangarun et al., 2019). There were also accounts of nausea, vomiting, mild cheilitis, and peeling of the palms and soles (Bilia et al., 2018).…”