Antioxidant and antidiabetic activity of Dangyuja (Citrus grandis Osbeck) extract treated with Aspergillus saitoi

Kim, Gyo-Nam; Shin, Jung-Geun; Jang, Hae‐Dong

doi:10.1016/j.foodchem.2009.03.072

Cited by 107 publications

(46 citation statements)

References 24 publications

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“…It has been reported that most baker's yeast inhibitors of a-glucosidase do not show any activity against mammalian a-glucosidase because of differences in the molecular recognition of the target-binding site of this enzyme (Kim et al, 2009). This might be the reason why blood glucose levels were not reduced in the maltose-loaded rats.…”

Section: Discussionmentioning

confidence: 99%

2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats

2010

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Five distinct organic compounds with protected and unprotected phenolic hydroxyl groups were screened for their a-glucosidase inhibitory potential. Of these compounds, 2,4,6-trihydroxybenzaldehyde (THB) showed the strongest noncompetitive a-glucosidase inhibition (IC 50 = 4.60 lM) and the most powerful antioxidant activity (DPPH assay) (IC 50 = 71.4 lM) in vitro. In in vivo studies, THB significantly reduced blood glucose levels in normal and diabetic rats after glucose load compared to maltose load.

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Section: Discussionmentioning

confidence: 99%

2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats

2010

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“…Plants contain phenolic compounds that experimentally exhibited properties of anti inflammatory (Menichini et al, 2011), anti microbial (Yi et al, 2008), anti adipogenesis (Kim et al, 2012a), and anti diabetic (Kim et al, 2009). All parts of plant such as fruit, seed, leave and root contain phenolic compounds to different extents (Kondo et al, 2002;Olabinri et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

FRACTIONATION OF PHENOLIC COMPOUNDS FROM KAFFIR LIME (Citrus hystrix) PEEL EXTRACT AND EVALUATION OF ANTIOXIDANT ACTIVITY

Wijaya

Widyadinata

Irawaty

et al. 2017

Reaktor

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“…It has been suggested that these side effects might be caused by the excessive inhibition of the pancreatic α-amylase, leading to the abnormal bacterial fermentation of undigested carbohydrates in the colon (Bischoff, 1994). Natural products which have been shown to possess a low inhibitory effect against α-amylase and high inhibition activity against α-glucosidase can be used as an effective means to reduce postprandial hyperglycaemia by inhibiting these enzymes in the intestines and thus, lowers carbohydrates absorption; with minimal adverse effects (Tarling et al, 2008;Kim et al, 2009;Shori, 2015). One of these medicinal plants used, is Gymnema sylvestre (Gurmar-sugar destroyer or killer; family: Asclepiadaceae).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant and Anti-Diabetic Potential of Gymnema Sylvestre Methanol Leaf Extract

Ibrahim

Tijjani

Yusuf

et al. 2017

ESJ

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Some medicinal plants and their purified derivatives have demonstrated beneficial therapeutic potentials for many centuries. They have been reported to exhibit antioxidant activity, reducing the oxidative stress in cells and are therefore useful in the treatment of many human diseases, including diabetes and other non-communicable diseases. This study evaluated antioxidative activity and enzymatic (alpha-amylase and alphaglucosidase) inhibitory potentials of Gymnema sylvestre methanolic leaf extract (GSMLE) using standard methods. Phytochemical screening revealed the presence of alkaloids, tannins, saponins, steroids, terpenoids and flavonoids. The total phenolics and total flavonoids content in the extract were found to be 6.629±0.745 (µg/ml of catechol equivalent) and 0.004±0.0012 (µg/ml of quercetin equivalent) respectively. GSMLE was shown to have radical scavenging activity against DPPH (290.54 ± 39.72 %), hydroxyl radical (86.507 ± 23.55 %) and hydrogen peroxide (45.25 ± 25.23 %). The level of SOD was significantly decreased in H2O2 induced and European Scientific Journal December 2017 edition Vol.13, No.36 ISSN: 1857 -7881 (Print) e -ISSN 1857 219 H2O2+extract induced when compared with normal control (p<0.05); the level of GSH was significantly increased in H2O2 induced control and significantly decreased in H2O2+extract induced test when compared to normal control. GSH was also decreased significantly in H2O2+extract induced when compared to H2O2 induced control (p<0.05). The extract also demonstrated significant inhibition of alpha-glucosidase (IC50 182.26 ±1.05μg/ml) when compared with standard acarbose (IC50 189.52±0.46) and was more potent than the arcarbose on alpha-amylase inhibition with IC50 of 195.3±4.40 and 200.05±7.16 respectively. These findings may therefore, stress the potentiality of using Gymnema sylvestre as a natural remedy for the management of type 2 diabetes.

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Antioxidant and antidiabetic activity of Dangyuja (Citrus grandis Osbeck) extract treated with Aspergillus saitoi

Cited by 107 publications

References 24 publications

2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats

2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats

FRACTIONATION OF PHENOLIC COMPOUNDS FROM KAFFIR LIME (Citrus hystrix) PEEL EXTRACT AND EVALUATION OF ANTIOXIDANT ACTIVITY

In Vitro Antioxidant and Anti-Diabetic Potential of Gymnema Sylvestre Methanol Leaf Extract

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