Antioxidant and anti-lipases activities in vitro of Mentha viridis and Eucalyptus globulus extracts

Belfeki, H.; Mejri, Mondher; Hassouna, Mnasser

doi:10.1016/j.indcrop.2016.06.002

Cited by 16 publications

(10 citation statements)

References 37 publications

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“…Some flavanols have also been reported to be potent inhibitors of pancreatic lipase activity 30,31 . Belfeki et al (2016) also reported a strong positive correlation between antioxidant capacity and digestive enzyme inhibitory activities of several plants 32 .…”

Section: Discussionmentioning

confidence: 95%

Hibiscus sabdariffa extract as anti-aging supplement through its antioxidant and anti-obesity activities

et al. 2020

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Introduction: Imbalance between total energy intake and expenditure causes accumulation of excess fat and sugar in the body which leads to development of diabetes mellitus type II, obesity, and metabolic syndrome. These harmful diseases accelerate aging and cause fatal metabolic disorders as people age. Inhibition of pancreatic lipase, and alpha glucosidase digestive enzymes is a step that can reduce excess fat and sugar from the body, which is an essential component of healthy aging. Methodology: In this study, aqueous and 50% ethanolic extracts of Hibiscus sabdariffa were investigated for their inhibitory activities on pancreatic lipase and alpha-glucosidase, in addition to their antioxidant activities (using UV-vis spectrophotometer). Results: Both extracts displayed antioxidant properties, indicated by IC50 of 5166.80 mg/mL for H. sabdariffa aqueous extract and 2809.10 mg/mL for H. sabdariffa 50% ethanolic extract. The extracts also suppressed the activities of pancreatic lipase and alpha-glucosidase enzymes, which suggests possible antiobesity and anti-diabetic activities. H. sabdariffa aqueous extract inhibited pancreatic lipase activity with IC50 of 167.5+/-12.7 mg/mL, whereas H. sabdariffa 50% ethanolic extract inhibited the enzyme with an IC50 of 790.65+/-16.02 mg/mL. Both H. sabdariffa aqueous and ethanolic extracts also successfully inhibited alpha-glucosidase enzyme activity with IC50 949.88 +/-10.83 mg/mL, and 378.33 +/-4.20 mg/mL, respectively. Conclusion: Taken together, the outcome of the investigations offers the possibility of the extracts as an anti-obesity, anti-diabetic, anti-metabolic and anti-aging agent, which can be developed into supplements for adults to prevent the occurrence of these prevalent diseases and delay the onset and effects of aging.

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Section: Discussionmentioning

confidence: 95%

Hibiscus sabdariffa extract as anti-aging supplement through its antioxidant and anti-obesity activities

et al. 2020

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“…Group VI was treated with silymarin at a daily dose of 50 mg/kg b.wt. (Belfeki, Mejri, & Hassouna, ). All tested material and silymarin were orally administered once daily for five consecutive days.…”

Section: Methodsmentioning

confidence: 99%

“…injection of CCl 4 (0.5 ml/kg b.wt. of 20% v/v CCl 4 solution in corn oil) was administered to all the groups except the normal group to induce liver injury (Belfeki et al, ). Blood was collected by a direct cardiac puncture under diethyl ether anesthesia 24 h after the last treatment dose.…”

Section: Methodsmentioning

confidence: 99%

Hepatoprotective activity of praecoxin A isolated from Melaleuca ericifolia against carbon tetrachloride‐induced hepatotoxicity in mice. Impact on oxidative stress, inflammation, and apoptosis

Al‐Sayed

Abdel‐Daim

Khattab

2018

Phytotherapy Research

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The hepatoprotective activity of praecoxin A, an ellagitannin from Melaleuca ericifolia, was determined against CCl 4 -induced toxicity in mice. Praecoxin A was administered (25, 50, and 100 mg/kg) for 5 days followed by CCl 4 . Praecoxin A markedly ameliorated the CCl 4 -induced increase in AST (by 19, 52, and 56%), ALP (22, 45, and 48%), ALT (11, 47, and 54%), total bilirubin (14, 27, and 28%), and MDA (26, 44, and 51%) at the tested doses, respectively, as compared with CCl 4 group. It was evident that praecoxin A significantly (p < 0.001) increased the antioxidant parameters GSH (45, 99, and 137%) and SOD (61, 129, and 159%). Histological findings revealed a marked amelioration of hepatocyte degeneration, necrosis, inflammatory cell infiltration, and hemorrhage in the groups treated with praecoxin A. COX-2 and caspase-3 hepatic expressions were significantly downregulated (p < 0.001) in praecoxin A-treated groups (up to 57, 83, and 93% for COX-2 and by 30, 82, and 99% for caspase-3). These findings suggest that praecoxin A exerts a beneficial effect against oxidative stress by reducing lipid peroxidation, enhancing the antioxidant defense status, and protecting against the histopathological changes induced by CCl 4 . This study highlights a promising natural hepatoprotective candidate derived from M. ericifolia that might be an alternative to silymarin.

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“…In fact, there are many studies involving the antipancreatic lipase properties of plants, including methanol extracts of fermented Camellia japonica (IC 50 = 0.308 mg/mL) [27]; ethanol extracts of Camelia sinensis (IC 50 = 0.5 mg/mL), Ceratonia siliqua (IC 50 = 0.8 mg/mL), Curcuma longa (IC 50 = 0.8 mg/mL), Sarcopoterium spinosum (IC 50 = 1.2 mg/mL), and Mentha spicata (IC 50 = 1.2 mg/mL) [28]; crude extract (IC 50 = 0.84 mg/mL), ethyl acetate extract (IC 50 = 0.88 mg/mL) and aqueous fraction (IC 50 = 0.63 mg/mL) of Oxalis cordata [32]. Eucalyptus globulus and Mentha viridis where evaluated for their inhibitory potential against lipase from Aspergillus niger and extracted from olive mesocarp [33]. The investigators found that methanol extracts from E. globulus and M. viridis presented greatest inhibition against lipase of Aspergillus niger (78.92 and 72.75%, respectively) and against lipase of olive (82.65 and 75.75%, respectively), where phenolic compounds might be a major contributor for the lipases inhibition [33].…”

Section: Naturally-occurring Lipase Inhibitorsmentioning

confidence: 99%

“…Eucalyptus globulus and Mentha viridis where evaluated for their inhibitory potential against lipase from Aspergillus niger and extracted from olive mesocarp [33]. The investigators found that methanol extracts from E. globulus and M. viridis presented greatest inhibition against lipase of Aspergillus niger (78.92 and 72.75%, respectively) and against lipase of olive (82.65 and 75.75%, respectively), where phenolic compounds might be a major contributor for the lipases inhibition [33]. Black tea (Camellia sinensis) theaflavins coupled with thearubigins are characteristic polyphenols in black tea, resulting from the oxidation of tea leaves during fermentation process [29].…”

Section: Naturally-occurring Lipase Inhibitorsmentioning

confidence: 99%

Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus

Duarte

Barroso

Gil

2020

Foods

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Type 2 Diabetes Mellitus (T2DM) is a chronic disease which corresponds to 90% of the worldwide cases of diabetes, mainly due to epigenetic factors such as unhealthy lifestyles. First line therapeutic approaches are based on lifestyle changes, most of the time complemented with medication mostly associated with several side effects and high costs. As a result, the scientific community is constantly working for the discovery and development of natural therapeutic strategies that provide lower financial impact and minimize side effects. This review focus on these nature-based therapeutic strategies for prevention and control of T2DM, with a special emphasis on natural compounds that present pharmacological activity as dipeptidyl peptidase-4 (DPP4), alpha-amylase, alpha-glucosidase, lipase, and protein tyrosine phosphatase 1B (PTP1B) inhibitors.

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Antioxidant and anti-lipases activities in vitro of Mentha viridis and Eucalyptus globulus extracts

Cited by 16 publications

References 37 publications

Hibiscus sabdariffa extract as anti-aging supplement through its antioxidant and anti-obesity activities

Hibiscus sabdariffa extract as anti-aging supplement through its antioxidant and anti-obesity activities

Hepatoprotective activity of praecoxin A isolated from Melaleuca ericifolia against carbon tetrachloride‐induced hepatotoxicity in mice. Impact on oxidative stress, inflammation, and apoptosis

Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus

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