Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus

Duarte, Ana M.; Barroso, Sónia; Gil, Maria M.

doi:10.3390/foods9030271

Cited by 42 publications

(36 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lack of adverse events is a clear advantage over classic pharmacological antidiabetic drugs that normally have side effects [ 142 ]. Nevertheless, we do not know yet whether postbiotics can provide the same benefits as current antidiabetic strategies or if they could be used in combination with classic antidiabetic drugs.…”

Section: Discussionmentioning

confidence: 99%

Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Cabello-Olmo

Araña

Urtasun

et al. 2021

Foods

View full text Add to dashboard Cite

In the last decade, the gastrointestinal microbiota has been recognised as being essential for health. Indeed, several publications have documented the suitability of probiotics, prebiotics, and symbiotics in the management of different diseases such as diabetes mellitus (DM). Advances in laboratory techniques have allowed the identification and characterisation of new biologically active molecules, referred to as “postbiotics”. Postbiotics are defined as functional bioactive compounds obtained from food-grade microorganisms that confer health benefits when administered in adequate amounts. They include cell structures, secreted molecules or metabolic by-products, and inanimate microorganisms. This heterogeneous group of molecules presents a broad range of mechanisms and may exhibit some advantages over traditional “biotics” such as probiotics and prebiotics. Owing to the growing incidence of DM worldwide and the implications of the microbiota in the disease progression, postbiotics appear to be good candidates as novel therapeutic targets. In the present review, we summarise the current knowledge about postbiotic compounds and their potential application in diabetes management. Additionally, we envision future perspectives on this topic. In summary, the results indicate that postbiotics hold promise as a potential novel therapeutic strategy for DM.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Cabello-Olmo

Araña

Urtasun

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…The substrate is also important. For example, when a synthetic substrate was used, alginate inhibited pancreatic lipase by 72.2 ± 4.1% vs. 58 ± 9.7% when olive oil was used as a natural substrate [ 173 ].…”

Section: Applications Of Alginate In the Medical Fieldmentioning

confidence: 99%

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

et al. 2020

View full text Add to dashboard Cite

Initially used extensively as an additive and ingredient in the food industry, alginate has become an important compound for a wide range of industries and applications, such as the medical, pharmaceutical and cosmetics sectors. In the food industry, alginate has been used to coat fruits and vegetables, as a microbial and viral protection product, and as a gelling, thickening, stabilizing or emulsifying agent. Its biocompatibility, biodegradability, nontoxicity and the possibility of it being used in quantum satis doses prompted scientists to explore new properties for alginate usage. Thus, the use of alginate has been expanded so as to be directed towards the pharmaceutical and biomedical industries, where studies have shown that it can be used successfully as biomaterial for wound, hydrogel, and aerogel dressings, among others. Furthermore, the ability to encapsulate natural substances has led to the possibility of using alginate as a drug coating and drug delivery agent, including the encapsulation of probiotics. This is important considering the fact that, until recently, encapsulation and coating agents used in the pharmaceutical industry were limited to the use of lactose, a potentially allergenic agent or gelatin. Obtained at a relatively low cost from marine brown algae, this hydrocolloid can also be used as a potential tool in the management of diabetes, not only as an insulin delivery agent but also due to its ability to improve insulin resistance, attenuate chronic inflammation and decrease oxidative stress. In addition, alginate has been recognized as a potential weight loss treatment, as alginate supplementation has been used as an adjunct treatment to energy restriction, to enhance satiety and improve weight loss in obese individuals. Thus, alginate holds the promise of an effective product used in the food industry as well as in the management of metabolic disorders such as diabetes and obesity. This review highlights recent research advances on the characteristics of alginate and brings to the forefront the beneficial aspects of using alginate, from the food industry to the biomedical field.

show abstract

“…Further, BCP has been attributed to exert inhibitory activity on pancreatic α-amylase, facilitates carbohydrate metabolism by interrupting α-1,4-glycosidic bonds to form oligosaccharides, that convert in to glucose [ 97 ]. Thus in addition to α-glucosidase, inhibiting α-amylase lessened hyperglycemia by delaying carbohydrate metabolism and reducing glucose absorption in intestine [ 97 ]. BCP present in many plants such as Afromomum melegueta and Afromomum danielli [ 88 ], Phlomis armeniaca WILLD., Phlomis nissolii L., and Phlomis pungens WILLD.…”

Section: Effects and Possible Mechanisms Of Bcp On Diabetesmentioning

confidence: 99%

“…The effect of BCP has been demonstrated on another enzyme, protein tyrosine phosphatase 1B (PTP1B) found in important insulin-targeted tissues such as liver, muscle, and fat and play a regulatory role in insulin signal transduction, by dephosphorylating activated insulin receptors or insulin receptor substrates. Excessive PTP1B activities impairs insulin sensitivity and signal transduction, thus participates in T2DM and regulate energy in brain mediating leptin receptors and contribute to obesity [ 97 ]. The inhibitors of PTP1B demonstrated to be useful in T2DM and obesity by favorable modulation of carbohydrate metabolism.…”

Section: Effects and Possible Mechanisms Of Bcp On Diabetesmentioning

confidence: 99%

Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications

et al. 2020

View full text Add to dashboard Cite

Diabetes mellitus (DM), a metabolic disorder is one of the most prevalent chronic diseases worldwide across developed as well as developing nations. Hyperglycemia is the core feature of the type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), following insulin deficiency and impaired insulin secretion or sensitivity leads insulin resistance (IR), respectively. Genetic and environmental factors attributed to the pathogenesis of DM and various therapeutic strategies are available for the prevention and treatment of T2DM. Among the numerous therapeutic approaches, the health effects of dietary/nutraceutical approach due to the presence of bioactive constituents, popularly termed phytochemicals are receiving special interest for pharmacological effects and therapeutic benefits. The phytochemicals classes, in particular sesquiterpenes received attention because of potent antioxidant, anti-inflammatory, and antihyperglycemic effects and health benefits mediating modulation of enzymes, receptors, and signaling pathways deranged in DM and its complications. One of the terpene compounds, β-caryophyllene (BCP), received enormous attention because of its abundant occurrence, non-psychoactive nature, and dietary availability through consumption of edible plants including spices. BCP exhibit selective full agonism on cannabinoid receptor type 2 (CB2R), an important component of endocannabinoid system, and plays a role in glucose and lipid metabolism and represents the newest drug target for chronic inflammatory diseases. BCP also showed agonist action on peroxisome proliferated activated receptor subtypes, PPAR-α and PPAR-γ, the main target of currently used fibrates and imidazolidinones for dyslipidemia and IR, respectively. Many studies demonstrated its antioxidant, anti-inflammatory, organoprotective, and antihyperglycemic properties. In the present review, the plausible therapeutic potential of BCP in diabetes and associated complications has been comprehensively elaborated based on experimental and a few clinical studies available. Further, the pharmacological and molecular mechanisms of BCP in diabetes and its complications have been represented using synoptic tables and schemes. Given the safe status, abundant natural occurrence, oral bioavailability, dietary use and pleiotropic properties modulating receptors and enzymes, BCP appears as a promising molecule for diabetes and its complications.

show abstract

Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus

Cited by 42 publications

References 88 publications

Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications

Contact Info

Product

Resources

About