Antioxidant and anti-inflammatory effects of fractions from ripe fruits of Solanum lycocarpum St. Hil. (Solanaceae) and putative identification of bioactive compounds by GC–MS and LC-DAD-MS

Morais, Melissa Grazielle; Saldanha, Aline Aparecida; Azevedo, Lucas Santos; Mendes, Iara Cotta; Rodrigues, João Paulo; Amado, Paula Avelar; Farias, Katyuce de Souza; Zanuncio, Vanessa Samúdio Santos; Cassemiro, Nadla Soares; Silva, Denise Brentan; Soares, Adriana Cristina; Lima, Luciana Alves Rodrigues dos Santos

doi:10.1016/j.foodres.2022.111145

Cited by 12 publications

(6 citation statements)

References 44 publications

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“…FRAP assay was performed according to Urrea-Victoria et al (2016) with modifications (Morais et al 2022). The HE and FAMEs, and the standard (BHT) were diluted to 3, 5, 10, 15 and 30 µg/mL in ethanol.…”

Section: Ferric-reducing Antioxidant Power (Frap) Assaymentioning

confidence: 99%

Chemical characterization, antioxidant activity, and cytotoxicity of fatty acids methyl esters from Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) seeds

Santos

Azevedo

Siqueira³

et al. 2023

Natural Product Research

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Handroanthus impetiginosus, popularly known as "ipê-roxo", is used in folk medicine to treat skin inflammations, infections, stomach diseases, and cancer. Fatty acid methyl esters (FAMEs) obtained from the esterification reaction of fatty acids (FA) found in the hexane extract (HE) of seeds of H. impetiginosus were identified by gas chromatography-mass spectrometry (GC-MS). The antioxidant and cytotoxic activities of the HE and FAMEs were evaluated. Methyl palmitate, methyl linoleate, methyl oleate, and methyl stearate were the major FAMEs obtained from the HE. The samples, especially the HE, exhibited a significant antioxidant potential analyzed by ferric reducing ability power (FRAP) assay. In the A. salina larvae bioassay, the HE showed no cytotoxic effects, but the FAMEs exhibited a high toxicity. This study reported, for the first time, the antioxidant and cytotoxic activities of the HE and FAMEs obtained from H. impetiginosus seeds.

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Section: Ferric-reducing Antioxidant Power (Frap) Assaymentioning

confidence: 99%

Chemical characterization, antioxidant activity, and cytotoxicity of fatty acids methyl esters from Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) seeds

Santos

Azevedo

Siqueira³

et al. 2023

Natural Product Research

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“…An ethyl acetate extract obtained from the ripe fruits of S. dulcamara demonstrates significant anti-inflammatory and antioxidant activity [92]. Moreover, S. dulcamara is reputed to possess a variety of therapeutic properties, including antimicrobial, analgesic, hepatoprotective, immunomodulatory, antitumor, and neurogenetic effects [93], as well as antioxidant [92], antihyperglycemic [94], antibacterial, and antimicrobial activity [95,96], and antirheumatic activity [97]. The aerial part of S. dulcamara is particularly rich in alkaloids, which contribute to its antibacterial activity against Streptococcus pyogenes, Staphylococcus epidermidis, and S. aureus.…”

Section: Taraxacum Officinale Web Family -Compositaementioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Berganayeva¹,

Kudaibergenova²,

Litvinenko³

et al. 2023

Preprint

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According to the eminent scholar, philosopher, and physician Avicenna, "the doctor has three tools: the word, the plant, the knife." The plant kingdom is recognized as humanity's earliest and most ancient healing source, employed for the management and prevention of illnesses. Tracing back through history, the most ancient documented proof of plants' utilization in medicine dates back to a Sumerian clay slab discovered in Nagpur roughly 5000 years ago. This artifact included a compilation of twelve medicinal recipes that involved over 250 diverse plant species. Sumerian healers extracted powders and infusions from plant roots and stems, while also crediting healing properties to pears and figs. Additionally, they utilized dried and ground young shoots of willow and plum trees, pine and fir needles as a component in compresses and poultices. Often, powders from animal and mineral sources were blended with those extracted from dried and crushed plants. Notably, in addition to water, wine and beer served as solvents. Thus, at least 80 centuries ago, people utilized the most uncomplicated medicinal plant-based preparations for treatment [1]. The "Pen T'Sao," an ancient Chinese text on roots and herbs, authored by Emperor Shen Nung approximately 2500 BC, contains descriptions of 900 medicaments (comprising dried components of medicinal plants). Several of these substances are still in use today, including Rhei rhisoma, camphor, Theae folium, Podophyllum, great yellow gentian, ginseng, datura, cinnamon bark, and ephedra [2]. Regarding Kazakh folk medicine, an area that has yet to be fully explicated and substantiated, it can be stated that the traditional medicinal knowledge of the Kazakh people transcends the mere treatment of ailments and rests on robust theoretical underpinnings. Oteiboydak Tleukabyluly (1388-1478), an astute healer and prominent figure in Kazakh folk medicine during the 15th century, comprehensively explicated the secrets of the healing art in his medical and ethnographic work "Medical Narrative," which he composed between 1466 and 1473 at the behest of az-Zhanibek Khan, who held him in high esteem as a great healer. This medical encyclopedia delineates the functions of various organs of the human body and provides a catalogue of the primary diseases associated with them. Furthermore, it includes a meticulous description of the methods used in traditional medicine at present, such as setting bones, listening to the pulse, and incantations. Through practical experimentation and experimentation conducted in the steppe laboratory, the healer formulated a total of 1,108 different medicinal compounds, of which 858 were derived from medicinal plants, 318 were extracted from animal organs, and roughly 60 were sourced from metals. The moniker "Teacher without a teacher" was bestowed on Oteiboydak Tleukabylov, who discovered methods for treating 1,050 different diseases [3]. At present, the employment of phytotherapy has gained widespread acceptance on a global scale. According to the World Health Organization's (WHO) global review of national policies concerning traditional, complementary, and alternative medicine, as well as the regulation of herbal medicines, there is an evident growth in the European and Asian market for herbal medicines [4]. Kazakhstan boasts a natural flora of over 6,000 plant species [5]. The exact number of medicinal plant species present in Kazakhstan remains uncertain, as the list continues to expand annually. More than 150 plant species have been employed in both official and folk medicine for various ailments. This review focuses on a selection of medicinal plants growing within the territory of the Republic of Kazakhstan that have traditionally been used to alleviate skin diseases. In conducting this study (2010-2023), emphasis was placed on the plants' phytochemical composition, with a particular focus on the principal components responsible for their therapeutic effects against inflammatory skin conditions such as dermatitis, atopic dermatitis, and eczema.

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“…Similarly, intraperitoneal administration of hexane (100 and 300 mg/kg) and hydroethanolic (100 mg/kg) fractions of ripe fruits of Solanum lycocarpum exerted strong anti-inflammatory activity and led to a significant suppression of carrageenan-induced paw edema in 4 and 6 h after induction of inflammatory signal. Stigmasterol was the main constituent detected from the fractions obtained and could be related to these activities [ 50 ].…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

“…In fact, this bioactive sterol extracted from different natural sources plays an important anti-inflammatory and analgesic role [ 48 ]. The anti-inflammatory properties of stigmasterol were assessed in vivo, and the underlying mechanism of action was demonstrated by molecular docking analysis [ 49 , 50 , 51 , 52 ].…”

Section: Introductionmentioning

confidence: 99%

Health Benefits and Pharmacological Properties of Stigmasterol

et al. 2022

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Stigmasterol is an unsaturated phytosterol belonging to the class of tetracyclic triterpenes. It is one of the most common plant sterols, found in a variety of natural sources, including vegetable fats or oils from many plants. Currently, stigmasterol has been examined via in vitro and in vivo assays and molecular docking for its various biological activities on different metabolic disorders. The findings indicate potent pharmacological effects such as anticancer, anti-osteoarthritis, anti-inflammatory, anti-diabetic, immunomodulatory, antiparasitic, antifungal, antibacterial, antioxidant, and neuroprotective properties. Indeed, stigmasterol from plants and algae is a promising molecule in the development of drugs for cancer therapy by triggering intracellular signaling pathways in numerous cancers. It acts on the Akt/mTOR and JAK/STAT pathways in ovarian and gastric cancers. In addition, stigmasterol markedly disrupted angiogenesis in human cholangiocarcinoma by tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor receptor-2 (VEGFR-2) signaling down-regulation. The association of stigmasterol and sorafenib promoted caspase-3 activity and down-regulated levels of the anti-apoptotic protein Bcl-2 in breast cancer. Antioxidant activities ensuring lipid peroxidation and DNA damage lowering conferred to stigmasterol chemoprotective activities in skin cancer. Reactive oxygen species (ROS) regulation also contributes to the neuroprotective effects of stigmasterol, as well as dopamine depletion and acetylcholinesterase inhibition. The anti-inflammatory properties of phytosterols involve the production of anti-inflammatory cytokines, the decrease in inflammatory mediator release, and the inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Stigmasterol exerts anti-diabetic effects by reducing fasting glucose, serum insulin levels, and oral glucose tolerance. Other findings showed the antiparasitic activities of this molecule against certain strains of parasites such as Trypanosoma congolense (in vivo) and on promastigotes and amastigotes of the Leishmania major (in vitro). Some stigmasterol-rich plants were able to inhibit Candida albicans, virusei, and tropicalis at low doses. Accordingly, this review outlines key insights into the pharmacological abilities of stigmasterol and the specific mechanisms of action underlying some of these effects. Additionally, further investigation regarding pharmacodynamics, pharmacokinetics, and toxicology is recommended.

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Antioxidant and anti-inflammatory effects of fractions from ripe fruits of Solanum lycocarpum St. Hil. (Solanaceae) and putative identification of bioactive compounds by GC–MS and LC-DAD-MS

Cited by 12 publications

References 44 publications

Chemical characterization, antioxidant activity, and cytotoxicity of fatty acids methyl esters from Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) seeds

Chemical characterization, antioxidant activity, and cytotoxicity of fatty acids methyl esters from Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) seeds

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Health Benefits and Pharmacological Properties of Stigmasterol

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