Chemical characterization, antioxidant activity, and cytotoxicity of fatty acids methyl esters from Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) seeds

Abstract

Handroanthus impetiginosus, popularly known as "ipê-roxo", is used in folk medicine to treat skin inflammations, infections, stomach diseases, and cancer. Fatty acid methyl esters (FAMEs) obtained from the esterification reaction of fatty acids (FA) found in the hexane extract (HE) of seeds of H. impetiginosus were identified by gas chromatography-mass spectrometry (GC-MS). The antioxidant and cytotoxic activities of the HE and FAMEs were evaluated. Methyl palmitate, methyl linoleate, methyl oleate, and methyl stearate were the major FAMEs obtained from the HE. The samples, especially the HE, exhibited a significant antioxidant potential analyzed by ferric reducing ability power (FRAP) assay. In the A. salina larvae bioassay, the HE showed no cytotoxic effects, but the FAMEs exhibited a high toxicity. This study reported, for the first time, the antioxidant and cytotoxic activities of the HE and FAMEs obtained from H. impetiginosus seeds.

Secondary metabolites, spectra characterization, and antioxidant correlation analysis of the polar and nonpolar extracts of Bryophyllum pinnatum (Lam) Oken

“…Additionally, oleic acid has demonstrated antioxidant benefits and is well-known for its role in lowering the risk of ROS-induced pathologies and enhancing the immune system (Rydlewski et al, 2017 ). Recent studies further support the findings on the antioxidant and radical scavenging activity of FAs and FAME (Santos et al, 2024 ), while research confirms that B. pinnatum contains phytochemicals of pharmaceutical and pharmacological relevance (Mbachu et al, 2019 ).…”

Assessing Spectral Analysis of Phytoconstituents and Their In Silico Interactions with Target Proteins in Plant Seed Extracts

“…These extracts may serve as natural sources of antioxidants based on their antioxidant activity [31,40,[49][50][51][52][53][54][55]. It was revealed that several bioactive compounds exist in this extract, including methyl oleate, isopropyl stearate, and 3,4-dihydroxy-1,6-bis-(3methoxy-phenyl)-hexa-2,4-diene-1,6-dione [54,[56][57][58]. There is evidence that such compounds contribute to the observed antimicrobial and antioxidant properties [31,50,[52][53][54][55].…”

“…Extracts from these plants showed significant antibacterial activity against Gram-positive bacteria, which is crucial given the rise in antibiotic resistance [14,[43][44][45][46][47][48]. These extracts may serve as natural sources of antioxidants based on their antioxidant activity [31,40,[49][50][51][52][53][54][55]. It was revealed that several bioactive compounds exist in this extract, including methyl oleate, isopropyl stearate, and 3,4-dihydroxy-1,6-bis-(3methoxy-phenyl)-hexa-2,4-diene-1,6-dione [54,[56][57][58].…”

“…It was revealed that several bioactive compounds exist in this extract, including methyl oleate, isopropyl stearate, and 3,4-dihydroxy-1,6-bis-(3methoxy-phenyl)-hexa-2,4-diene-1,6-dione [54,[56][57][58]. There is evidence that such compounds contribute to the observed antimicrobial and antioxidant properties [31,50,[52][53][54][55]. Furthermore, human breast cancer cells (MCF-7) were found to be cytotoxic in a dosedependent manner, while normal fibroblast cells (L929) were not affected.…”