Antioxidant activity and protective effects of commercial propolis on gentamicin induced nephrotoxicity in rabbits- In vitro study

Osman, Ismail H.; Tantaway, Ahmed Abdel Hafez

doi:10.5505/tjb.2013.29200

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…This effect is probably due to the antioxidant protective effect of propolis which could have accumulated in the cells of the proximal convoluted tubules of the kidney where propolis was reported to be collected and secreted [156]. Osman and Tantaway [157] observed that oral administration of propolis extracts to rabbit significantly protected against histopathological alterations induced by gentamicin. Atta et al [158] found that propolis ameliorated the renal alterations induced by gentamicin administration as indicated by maintenance of the activity of antioxidant enzymes.…”

Section: Propolismentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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Section: Propolismentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Effects of short‐ and long‐term use of propolis extracts on liver and kidney in rats

Silici,

Demiray,

Okan

et al. 2024

Food Science & Nutrition

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Propolis is widely used as a supplementary food product for its health benefits. The aim of this study was to determine the effects of commercial propolis extracts on the liver and kidney. Propolis extracts (250 mg/kgbw/day) were administered orally to adult male Wistar albino rats in solvents of ethanol, propylene glycol, water, and olive oil. Liver enzyme levels were determined biochemically in blood samples, and histopathological examinations were performed on the liver. Damage rate in both kidney tissue in the propolis‐ethanol extract group increased significantly compared with the other groups after 30 and 90 days of application (p < .05). According to the results, ethanol, used as a common solvent in propolis products, may adversely affect the liver in long‐term use. The data indicate that propolis‐olive oil extract may be an essential alternative due to its effective and reliable properties.

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Effect of nettle (Urtica dioica) extract on gentamicin induced nephrotoxicity in male rabbits

Salih

2015

Asian Pacific Journal of Tropical Biomedicine

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Antioxidant activity and protective effects of commercial propolis on gentamicin induced nephrotoxicity in rabbits- In vitro study

Cited by 4 publications

References 27 publications

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Effects of short‐ and long‐term use of propolis extracts on liver and kidney in rats

Effect of nettle (Urtica dioica) extract on gentamicin induced nephrotoxicity in male rabbits

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