Effect of nettle (Urtica dioica) extract on gentamicin induced nephrotoxicity in male rabbits

Salih, Nadia Abdulkarim

doi:10.1016/j.apjtb.2015.07.005

Cited by 13 publications

(9 citation statements)

References 16 publications

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“…The authors received a more effective anti-inflammatory drug than traditional tincture of nettles for the treatment of inflammatory disorders, especially arthritis. Salih (2015) states that 95% of nettle extract protect the nephrons from oxidative damage, due to the high content of phenols and high antioxidant activity. Wolska et al (2015) indicate the ability of both aqueous and 70% ethanolic extracts to increase the activity of catalase in isolated monocytes of leukemia-affected individuals, although the best effect on enzyme activity was characteristic of ethanolic extract of nettle.…”

Section: Discussionmentioning

confidence: 99%

“…The nettle is characterized by a multivitamin, antibacterial, antidiabetic, choleretic, anti-inflammatory, hemostatic, and tonic effect. It stimulates metabolism, increases the muscle tone of the internal organs, improves the activity of the cardiovascular and respiratory systems, the liver, reduces alcohol intoxication, strengthens the mucus and exhibits adaptogenic action (Chendey et al, 2013;Salih, 2015;Zemmouri et al, 2017;Namazi et al, 2018). Nettle leaves used as an antimicrobial, antihypertensive, and anti-tumour agent (Teloa et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…The nettle includes the whole range of essential and non-essential amino acids, lipids and fatty acids, nitrogen-containing compounds, essential oils, steroids, lectins, lignans, coumarins, histamine, pigments, vitamins B 1 , B 2 , C, E, K, PP, carotene, tannins, flavonoids, trace elements (Cu, Zn, Fe, Mg, Pb, Mn) and macroelements (K, Ca, P, Na). Stems and leaves are covered with hairs containing silicon (Kopyt'ko et al, 2011;Ahmed et al, 2012;Salih, 2015;De Vico et al, 2018). The dry nettle preparation contains about 35% crude protein, 23% -carbohydrates, 1% -lysine, 0.32% -cystine, 0.52% -methionine (Rutto et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Metabolic processes in the organism of animals under the action of plant extract

Buchko

Havryliak

Yaremkevych

et al. 2019

Regul. Mech. Biosyst.

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The possibility of increasing metabolism and resistance in an organism of animals under the influence of biologically active substances of natural origin is considered in the paper. In the current study, we investigated the effect of 40% ethanolic extract of common nettle (Urtica dioica L.) on hematologic indexes (hemoglobin concentration, erythrocytes and leukocytes content), protein metabolism (total protein, aspartate aminotransferase (AST), alanine aminotransferase activities (ALT)), glutathione metabolism (peroxidase (GP), glutathione reductase (GR) and reduced glutathione content (GSH)), antioxidant defense systems (superoxide dismutase (SOD), catalase (CAT)), and indicators of free radical processes (lipid hydroperoxidation products (LHP), TBA-active products and carbonyl groups of protein (CP)) in the blood and tissues of normal and adrenalin-stressed rats. White Wistar rats (male) with body weight 180–200 g were used in the experiments. The animals were divided into 4 groups (control and 3 experimental), each containing 7 animals. The animals of experimental groups D2 and D3 received 40% ethanolic extract of common nettle in a dose of 5 mL/kg of body weight during 4 weeks. After 29 days of the experiment, the animals of D1 and D3 groups were intramuscularly administered 0.1% solution of adrenaline hydrochloride at a dose of 1 mg/kg of body weight. One day after the administration of adrenaline, the animals were decapitated under ether anesthesia. The objects of the study were blood and homogenates of liver, heart, and kidneys of the rats. Our results have shown that adrenaline stress causes a decrease in the concentration of hemoglobin, LHP, SOD activity and increase in activities of AST, GP, GR, and GSH content in the blood of rats. Stress induced by adrenaline was accompanied by decrease in CP content, activities of SOD, CAT, and increase in the glutathione chain of antioxidant defense system in the liver of the animals while in the heart and kidneys, there was an increase in oxidative stress parameters and decrease in antioxidant enzyme activities (SOD, CAT, GP, GR). The administration of ethanolic extract of nettle caused an increase within the physiological range in the erythrocytes and leucocytes content, hemoglobin concentration, and normalization of protein metabolism (decrease in the activity of AST and increase in protein concentration) in the blood of the stressed rats. The activation of the antioxidant defense system (increase in activities of SOD, GP, CAT, GR) and inhibition of free radical processes (decrease in concentration of LHP, TBA-active products and CP) was observed in the tissues of animals of D2 and D3 groups. Our results suggested that using a complex of biologically active substances of the common nettle ethanolic extract prevents metabolic disorders and stresses of different etiology through the activation of the antioxidant defense system, the normalization of protein metabolism and stimulation of hematopoiesis both in normal and stressed rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metabolic processes in the organism of animals under the action of plant extract

Buchko

Havryliak

Yaremkevych

et al. 2019

Regul. Mech. Biosyst.

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“…Additionally, it has been suggested that polyphenolic and flavonoids in the diet are associated with longer life expectancy. Moreover, nephron protective effect of vitamin E mediated by its antioxidant effect has been proved (Salih, 2015). This plant contains quercetin.…”

Section: Effect Of P Ruscifolia Extract On the Parameters Of The Renal Profilementioning

confidence: 99%

Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice

2019

J app pharm sci

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Liver and kidney are vital organs for body homeostasis and are exposed to damage or injury of various origins. Many medicinal plants have proved to be effective for hepatic and renal diseases. This study aimed to test the effect of Prosopis ruscifolia Griseb. leaves extract on acetaminophen-induced hepatotoxicity and gentamicin-induced nephrotoxicity. The experiment was carried out in mice, 300 mg/kg of acetaminophen, i.p., and 135 mg/kg of gentamicin were used to induce liver and kidney damage, respectively. Silymarin was used as protective control drug. For estimating the liver function, alkaline phosphatase (ALP), aspartate aminotransferase (AST or GOT), and alanine aminotransferase (ALT or GPT) were measured; and creatinine, urea, and uric acid were determined in order to verify kidney functionality. The results showed that the extract has both hepatoprotective and nephroprotective effect. This is evidenced by reduced values of the level of GOT, GPT, and ALP, in mice co-administered, p.o., with P. ruscifolia; and by the reduction of serum creatinine in mice with gentamicin induced kidney damage. These values showed statistically significant difference when compared with those of pathological group. The alcoholic extract of P. ruscifolia denoted hepatoprotective and nephroprotective effects.

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“…Traditionally, it has been used for complaints associated with nasal and menstrual haemorrhage, rheumatism, eczema, anaemia, nephritis, haematuria, jaundice, menorrhagia, diarrhea, osteoarthritis, urinary tract infections, rheumatoid arthritis, allergies, Alzheimer's, asthma, bladder problems, bronchitis, bursitis, gingivitis, gout, cough, hair growth, kidney stones, prostate enlargement, tendinitis, gastrointestinal tract, also as blood purifier, emmenagogue, diuretic [10,11,12]. Phytochemical studies have shown that the main constituents of Urtica dioica are flavonoids (kaempferol, isorhamnetin, quercetin, isoquercitrin, astragalin, and rutin), other phenolics ( phenylpropanes, caffeic acid, chlorogenic acid and scopoletin), tannins, essential oil (carvacrol, carvone, naphthalene, (E)-anethol, hexahydrofarnesyl acetone, (E)-geranyl acetone, (E)-β-ionone phytol), fatty acids, polysaccharides, isolectins, sterols, terpenes, protein, vitamins (A, B1, B2, C, D, E, K) and minerals (calcium, chromium, cobalt, copper, iron, magnesium, phosphorus, potassium, silicon, sodium, sulfur, zinc) [10,11]. It has also been reported that various extracts obtained from Urtica dioica have significant antioxidant, antidiabetic, hepatoprotective, anti-hyperlipidemic, diuretic, antiviral, antimicrobial, cardiovascular, anti-inflammatory, analgesic, anti-arthritic, immunomodulatory, anticancer, hypotensive, and anthelmintic activities [10].…”

Section: Introductionmentioning

confidence: 99%

The effects of Urtica dioica L. ethanolic extract against urinary calculi in rats

KELEŞ¹,

Şen²,

Ertaş³

et al. 2020

jrp

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Nephrolithiasis is common urological problem and stone formation has multiple underlying pathogenetic factors. We investigated the possible preventive and therapeutic effects of Urtica dioica ethanol extract (UD) on ethylene glycol-induced nephrolithiasis model in rats. Sprague-Dawley rats were divided into four groups (n = 10). The control group was given normal drinking water for 8 weeks and was administered vehicle by gastric gavage. Stone formation was induced by adding 0.75% ethylene glycol (EG) to their drinking water. UD (700 mg/kg) was given orally for 8 weeks to the preventive group and for last 4 weeks to the treatment group, respectively. At the end of the experiment, urine, blood samples and kidney tissues were obtained. In 24-hour urine samples, calcium and citrate levels were decreased and oxalate levels were increased in EG group whereas UD treatment groups reversed these parameters back to control levels. In addition, serum levels of creatinine and urea were increased in EG group, while UD significantly reduced these parameters. Malondialdehyde, 8-hydroxydeoxyguanosine and tumor necrosis alpha levels, and caspase-3 and N-acetyl-β-glucosaminidase activities were elevated in EG group and showed a decrease in UD treated groups. Glutathione level was decreased in EG group, whereas it was increased in UD preventive group. Histological examination showed an improvement in UD treated groups. Our results suggest that UD is effective both in prevention and treatment for kidney stones. The mechanism underlying this effect may be the antioxidant effect of UD and the effect on the concentration of stone-forming components in the urine.

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Effect of nettle (Urtica dioica) extract on gentamicin induced nephrotoxicity in male rabbits

Cited by 13 publications

References 16 publications

Metabolic processes in the organism of animals under the action of plant extract

Metabolic processes in the organism of animals under the action of plant extract

Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice

The effects of Urtica dioica L. ethanolic extract against urinary calculi in rats

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