Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab, Azab Elsayed; Albasha, Mohamed Omar; Elsayed, Ata Sedik Ibrahim

doi:10.4236/ym.2017.14023

Cited by 35 publications

(27 citation statements)

References 128 publications

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“…Natural antioxidants have a variety of biochemical actions such as inhibition of the production of ROS and scavenging of free radicals. 2,61,62 Azab et al, 2 reported that consumption of fenugreek, curcumin, peppermint, parsley, rosemary, garlic, pomegranate, sesame, and propolis were shown protective effects against renal diseases and nephrotoxic agents induced renal dysfunctions in experimental animals and human. The nephroprotective effect may be due to the inhibition of tissue lipid peroxidation and enhancement of antioxidant activity.…”

Section: Natural Antioxidantsmentioning

confidence: 99%

“…An imbalance between free radicals and antioxidants leads to oxidative damage of proteins, fat, nucleic acids, and carbohydrates. 1,2 Antioxidants have protected the body from the harmful effect of the free radicals. 2,3 Endogenous antioxidants defense against the reactive oxygen species are strengthened by natural antioxidants that strengthen them and restore the optimal balance by neutralizing the ROS.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Antioxidants have protected the body from the harmful effect of the free radicals. 2,3 Endogenous antioxidants defense against the reactive oxygen species are strengthened by natural antioxidants that strengthen them and restore the optimal balance by neutralizing the ROS. 2,[4][5][6][7] Traditional medicine has been used a number of natural and herbal products to treat a variety of diseases including malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and antioxidant mechanisms in human body

Azab¹,

Adwas²,

Elsayed³

et al. 2019

JABB

193

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The present review aims to high light on the oxidative stress, and prevention by internal antioxidants and external antioxidants by some natural products possessing antioxidant properties. Oxidative stress occurs when the balance between reactive oxygen species (ROS) formation and detoxification favors an increase in ROS levels, leading to disturbed cellular function. ROS causes damage to cellular macromolecules causing lipid peroxidation, nucleic acid, and protein alterations. Their formation is considered as a pathobiochemical mechanism involved in the initiation or progression phase of various diseases such as atherosclerosis, ischemic heart diseases, diabetes, and initiation of carcinogenesis or liver diseases. In order to maintain proper cell signaling, it is likely that a number of radical scavenging enzymes maintain a threshold level of ROS inside the cell. However, when the level of ROS exceeds this threshold, an increase in ROS production may lead to excessive signals to the cell, in addition to direct damage to key components in signaling pathways. ROS can also irreversibly damage essential macromolecules. Protein-bound thiol and non-protein-thiol are the major cytosolic low molecular weight sulfhydryl compound that acts as a cellular reducing and a protective reagent against numerous toxic substances including most inorganic pollutants, through the –SH group. Hence, thiol is often the first line of defense against oxidative stress. Flavonoids have been found to play important roles in the non-enzymatic protection against oxidative stress, especially in the case of cancer. Flavonoids have occurred widely in tea, fruit, red wine, vegetables, and cocoas. Flavonoids, including flavones, flavanone, flavonols, and isoflavones, are polyphenolic compounds which are widespread in foods and beverages, and possess a wide range of biological activities, of which anti-oxidation has been extensively explored. It can be concluded that oxidative stress causes irreversible damage in cellular macromolecules that leads to initiation of various diseases such as atherosclerosis, ischemic heart diseases, liver diseases, diabetes, and initiation of carcinogenesis. Antioxidants inhibit reactive oxygen species production and scavenging of free radicals. Therefore, the review recommends that high consumption of natural foods that are rich in antioxidants will provide more protection against toxic agents and related diseases.

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Section: Natural Antioxidantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and antioxidant mechanisms in human body

Azab¹,

Adwas²,

Elsayed³

et al. 2019

JABB

193

View full text Add to dashboard Cite

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“…Exposure to chemical reagents like ethylene glycol, CCl 4 , sodium oxalate, and heavy metals induce nephrotoxicity. Prompt recognition of the disease and termination of responsible drugs are usually the only necessary therapy (Azab et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

et al. 2019

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Background: There is a growing demand for remedies from natural sources to substitute synthetic therapeutic drugs and minimize their side effects and toxicity. The present study aims to evaluate the defensive ability of an ethanolic extract of Rosmarinus officinalis L. in carbon tetrachloride (CCl 4)-induced nephrotoxicity in male albino rats. Materials and methods: Thirty-six rats were divided into 6 groups (n = 6). Group I (control) received distilled water for 30 days orally. Nephrotoxicity was induced by CCl 4 (11% v/v with olive oil, i.p) 2 ml/kg body weight (b.wt.) in group II once a week for 30 days. Groups III and IV received the only herb in two doses 100 and 250 mg/kg of b.wt. respectively. Groups V and VI received an ethanolic extract of Rosmarinus officinalis (EERO, 100 and 250 mg/kg of b. wt.) along with 2 ml/kg b.wt. CCl 4 weekly for 30 days. Results: CCl 4 treatment induced highly significant (P < 0.001) elevation in kidney biomarkers, i.e., blood urea nitrogen and creatinine, kidney biochemicals, i.e., LPO and XOD, and decrease the levels of superoxide dismutase, catalase, glutathione peroxidase, and glutathione in tissue. However, EERO significantly (P < 0.001) restored the altered levels of these biomarkers in a dose-dependent manner. Furthermore, EERO also prevents histological alteration caused due to the toxicity of CCl 4. Conclusion: Our findings strongly support that ethanolic extract of Rosmarinus officinalis acts as a potent scavenger of free radicals to prevent the toxic effect of CCl 4 and hence validate its ethnomedicinal use.

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“…On the other hand, propolis is known to prevent cells from oxidative damage as an antioxidant. Many vegetables and fruits were studied in those aspects, among which propolis was superior [5,6,7] . One of these studies indicated that the antioxidant capability of propolis was 62 and 120 times of that of pomegranate and tomato, which were previously recognized as the most effective antioxidants [8] .…”

Section: Propolismentioning

confidence: 99%

A New Antibacterial Agent: Propolis

Inşaatçi

Turan

2018

Mater. Chem. Phys.

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<p class="pre" align="justify">As textile products are being used widely in Daily life, their antibacterial characteristics gain more importance. The necessity of antibacterial agents used due to the importance given to today's health and alternative products provided by natural routes has also revealed the necessity of this context. This work focuses on the usage of propolis as an antibacterial agent. On the other hand, it aims to gather information on the use of propolis for the purpose of giving antibacterial properties to textile materials. </p>

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Prevention of Nephropathy by Some Natural Sources of Antioxidants

Cited by 35 publications

References 128 publications

Oxidative stress and antioxidant mechanisms in human body

Oxidative stress and antioxidant mechanisms in human body

Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

A New Antibacterial Agent: Propolis

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