Antioxidant Activities in Methanolic Extracts of Olea Ferruginea Royle Fruits

Sharma, Richa; Sharma, Neeta; Samant, S. S.; Nandi, Shyamal K.; Palni, L. M. S.

doi:10.7763/ijbbb.2013.v3.185

Cited by 8 publications

(8 citation statements)

References 13 publications

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“…Moreover, the DPPH scavenging activity of various extracts of olive seeds demonstrated an antioxidant effect in the current study similar to the different leaf extracts of olive trees [ 19 ]. This study confirmed that the seeds of Indian olive had exhibited dose-dependent DPPH and alpha-amylase inhibitory potential that might be attributed to the presence of natural phenols and flavonoids [ 20 ].…”

Section: Discussionsupporting

confidence: 71%

Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp. Cuspidata (Indian Olive) Seed Extracts

Akhtar

Ashraf

Saleem

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The aim of the present study was to evaluate the antioxidant and antidiabetic potential of Indian olive seed extracts. Plant seeds were sequentially extracted with n-hexane, chloroform, methanol, and water. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging and alpha-amylase inhibitory activities of extracts were carried out. Olea europaea methanolic extract (MEOE) and aqueous extract (AEOE) were orally administered to normoglycemic and alloxan-treated diabetic rats so as to determine their hypoglycemic effect. High-performance liquid chromatography (HPLC) analysis showed gallic acid, ferulic acid, quercetin, and vanillic acid in MEOE. It was found that the methanolic and aqueous extracts exhibited the maximum DPPH and alpha-amylase inhibition activities, respectively. MEOE and AEOE exerted a significant decline in the fasting blood sugar in diabetic animals ( p < 0.05 ); however, they did not cause hypoglycemia in nondiabetic animals. Treatment with MEOE and AEOE reduced the aggravated liver and kidney function biomarkers. Aggravated levels of oxidative stress biomarkers including superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and malondialdehyde (MDA) were restored by treatment with MEOE. Moreover, MEOE improved the count of islets of Langerhans in the pancreas, fatty changes, and enlarged sinusoidal spaces in the liver and necrosis of the glomerulus and tubular cells of the kidney in diabetic rats. This study showed that the African olive seed extract effectively managed experimental diabetes and restored the normal functions and histology of the liver and kidney in diabetic rats through the reduction of oxidative stress.

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Section: Discussionsupporting

confidence: 71%

Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp. Cuspidata (Indian Olive) Seed Extracts

Akhtar

Ashraf

Saleem

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Field survey was conducted while recording GPS points of O. ferruginea sightings. Before conducting the survey, literature was studied regarding Olea growing regions in Pakistan [4,10,[33][34][35]. These geographical coordinates were helpful in locating the areas of O. ferruginea distribution.…”

Section: Data Collectionmentioning

confidence: 99%

Predicting the Potential Distribution of Olea ferruginea in Pakistan incorporating Climate Change by Using Maxent Model

et al. 2016

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Abstract:The potential distribution of Olea ferruginea was predicted by Maxent model for present and the upcoming hypothetical (2050) climatic scenario. O. ferruginea is an economically beneficial plant species. For predicting the potential distribution of O. ferruginea in Pakistan, Worldclim variables for current and future climatic change scenarios, digital elevation model (DEM) slope, and aspects with the occurrence point were used. Pearson correlation was used to reject highly correlated variables. A total of 219 sighting points were used in the Maxent modeling. The area under curve (AUC) value was higher than 0.98. The approach used in this study is considered useful in predicting the potential distribution of O. ferruginea species, and can be an effective tool in the conservation and restoration planning for human welfare. The results show that there is a significant impact under future bioclimatic scenarios on the potential distribution of O. ferruginea in Pakistan. There is a significant decrease in the overall distribution of O. ferruginea due to loss of habitats under current distribution range, but this will be compensated by gain of habitat at higher altitudes in the future climate change scenario (habitat shift). It is recommended that the areas predicted suitable for the O. ferruginea may be used for plantation of this species while the deforested land should be restored for human welfare.

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“…Oleanolic acid, a biologically active compound isolated from the chloroform extract of Olea ferruginea R, has been shown to exhibit antitumor, antimicrobial, hepatoprotective, and antiallergic potential [17], while neuroprotective effects were observed in a focal brain hypoxia rat model [18]. Moreover, the fruit of Olea ferruginea R were reported to possess antioxidant [19] and hepatoprotective activity against fluoride-induced toxicity in mice [20]. More recently, the bark and leaves of Olea ferruginea R have shown to possess antimicrobial and antioxidant potential [21].…”

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confidence: 99%

Investigation of Olea ferruginea Roylebark extracts for potential in vitro antidiabetic and anticancer effects

et al. 2021

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Introduction Medicinal plants have been utilized to treat various ailments all over the world, although specific to every region [1]. Regarded as a natural treasurer, these sources are plentiful and can be utilized in galenical products in a safe, standardized, and effective manner with subsequent use in primary health care facilities [2]. History has revealed that humans have been benefiting from these herbal consecrations for almost 60,000 years and they can be consumed either directly or in the form of the active constituent isolated from them [3]. As of today, an estimated 50,000 medicinal plant species have afforded health benefits to approximately 80% of the world's population [4]. Pakistan, with climatic variations and rich soil, offers the finest conditions for the growth of flora across the country. It is estimated that about 12% of the flora in Pakistan is used for medicinal purposes, while some of them are exported [5]. Almost 6000 plant species have been discovered in Pakistan, of which 1000 are used for medicinal purpose [6]. It has also been estimated that 70% of the total species are uniregional and about 30% are bi-or pluriregional. The country has four phytogeographical regions, comprising Irano-Turanian (45% of the species), Sino-Himalayan (10%), Saharo-Sindian (9.5%), and the Indian element (6%) [7]. Olea ferruginea R, locally known as Indian olive or Kahoo [8], a well-known medicinally important plant, is widely distributed in different areas of Pakistan, such as Swat valley, Salt Range, Soon valley, the western hills of Balochistan, lower hills of Azad Kashmir, Waziristan, Dir, Chitral, and Murree Hills [9]. The genus Olea includes around 30 to 40 species that are distributed in Oceania, Asia, Africa, and the Mediterranean Basin [10]. Numerous reports have suggested that different parts of Olea ferruginea R have many traditional uses, such as the leaves, which are used to treat bleeding gums, gonorrhea, whooping cough, skin problems, skeleton-muscular problems, and tooth ache, while its bark is used to treat fever [11,12] and the dried fruit has an antidiabetic effect [13]. Additionally, the olive oil extracted from its fruit and seeds reduces swelling and pain related to rheumatoid arthritis [14]. The leaves of Olea ferruginea R possess glucose lowering and

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Antioxidant Activities in Methanolic Extracts of Olea Ferruginea Royle Fruits

Abstract: Abstract-Olea ferruginea

Cited by 8 publications

References 13 publications

Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp. Cuspidata (Indian Olive) Seed Extracts

Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp. Cuspidata (Indian Olive) Seed Extracts

Predicting the Potential Distribution of Olea ferruginea in Pakistan incorporating Climate Change by Using Maxent Model

Investigation of Olea ferruginea Roylebark extracts for potential in vitro antidiabetic and anticancer effects

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