Antioxidant activities and phytochemical constituents of Antidesma thwaitesianum Müll. Arg. leaf extracts

Dechayont, Bhanuz; Itharat, Arunporn; Phuaklee, Pathompong; Chunthorng-Orn, Jitpisute; Juckmeta, Thana; Prommee, Nuntika; Nuengchamnong, Nitra; Hansakul, Pintusorn

doi:10.1016/s2095-4964(17)60334-0

Cited by 10 publications

(21 citation statements)

References 17 publications

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“…Total phenolic content (TPC) was measured using the Folin-Ciocalteu assay with some modifications by Dechayont et al [16]. The principle of this assay is the reduction of the Folin-Ciocalteu reagent in the presence of phenolics, resulting in the production of molybdenum-tungsten blue.…”

Section: Determination Of Total Phenolic Contentmentioning

confidence: 99%

Biological Sciences and Biotechnology

Seubsasana¹,

Dechayont²,

Pipatrattanaseree³

et al. 2023

ScienceAsia

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Diabetes mellitus (DM) is a chronic metabolic disorder associated with persistent hyperglycemia. Globally, the number of people with DM has quadrupled in the past three decades, and type 2 diabetes mellitus (T2DM) accounts for around 90% of all cases of diabetes. The role of oxidative stress is well established in T2DM pathogenesis. The synthetic drugs for T2DM are associated with serious side effects. Antioxidant and α-glucosidase inhibitory actions of phytochemicals from various plant species are considered an alternative to the synthetic drugs for T2DM management. This study aimed to evaluate the antioxidant activity, α-glucosidase inhibition, and phytochemical profiling of Belosynapsis ciliata. The total phenolic and flavonoid contents, antioxidant activity of 1,1-diphenyl-2picrylhydrazyl (DPPH) free radical, 2,2 -azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radical, and nitric oxide (NO) radical, and α-glucosidase inhibition of B. ciliata extracts were determined spectrophotometrically. The ethyl acetate extract form B. ciliata had highly potent scavenging activities for DPPH (EC 50 ; 80.02 ± 4.34 µg/ml) and ABTS (EC 50 ; 97.07 ± 1.52 µg/ml). Meanwhile, the dichloromethane extract possessed a good scavenging of NO (IC 50 ; 121.65 ± 3.48 µg/ml) and had the highest α-glucosidase inhibitory activity (IC 50 ; 33.28 ± 1.36 µg/ml). This study demonstrated the promising antioxidant activities, and α-glucosidase inhibitory action of B. ciliata was probably due to the presence of phenolic and flavonoid contents. The finding provided us with the leads to proceed with the development of medicinal plant having antidiabetic attributes.

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Section: Determination Of Total Phenolic Contentmentioning

confidence: 99%

Biological Sciences and Biotechnology

Seubsasana¹,

Dechayont²,

Pipatrattanaseree³

et al. 2023

ScienceAsia

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“…DPPH radical scavenging activity was measured using a slightly modified method of Dechayont et al [9]. DPPH solution in absolute ethanol was newly prepared before use and protected from light.…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Phuaklee¹,

Dechayont²,

Chunthorng-Orn³

et al. 2021

ScienceAsia

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“…e Griess reagent was used to determine nitrite, which is a stable end product of NO in cell culture supernatants. e inhibitory effect on NO 2 Evidence-Based Complementary and Alternative Medicine production was evaluated using the method of Dechayont et al [23]. Cytotoxicity was also determined using the MTT method.…”

Section: Determination Of Anti-inflammatory Activity By Nitricmentioning

confidence: 99%

Anti‐Helicobacter pylori, Anti‐Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans

Suthisamphat

Dechayont

Phuaklee

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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e aril (mace) of Myristica fragrans, known as Dok-Chan, is a spice that has long been used for treating stomach discomfort, peptic ulcer, and nausea. It is an ingredient in many remedies in ai traditional medicine, e.g., Ya-Hom-ep-Bha-Jit, Ya-Hom-Nao-Wa-Kot, and Ya-at-Bun-Job, which are used to treat dyspepsia and other gastrointestinal tract symptoms. e aqueous and ethanolic extracts of mace were used for all tests. Anti-H. pylori activities were determined by the disc diffusion method and agar dilution. Anti-inflammatory activity was determined by the LPS-induced nitric oxide (NO) inhibition in a RAW264.7 cell line, and cytotoxicity was determined against gastric cancer cell lines (Kato III) using the sulphorhodamine B (SRB) assay. e DPPH radical scavenging and ABTS radical cation decolorization assays were used to determine the antioxidant activities. e result found that the ethanolic extract of mace exhibited antimicrobial activity against H. pylori ATCC 43504 and six clinical strains with MIC values of 125-250 μg/ml. e aqueous extract MICs against H. pylori ATCC reference strain and six clinical strains were 500 μg/ml compared with 0.5 μg/ml for the positive control, clarithromycin. e inhibitory effect of LPS-induced NO release and cytotoxic activity of the ethanolic extract had IC 50 values of 82.19 μg/ml and 26.06 μg/ml, respectively, and the EC 50 values for the DPPH and ABTS antioxidant assays were 13.41 μg/ml and 12.44 μg/ml, respectively. e mace extract also had anticancer properties. In conclusion, the ethanolic mace extract had anti-H. pylori, anti-inflammatory, antioxidant, and anticancer activities. ese data support further preclinical and clinical investigation to see if the mace extract could have a role in treating patients with dyspepsia, peptic ulcers, and possibly gastric cancer.

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Antioxidant activities and phytochemical constituents of Antidesma thwaitesianum Müll. Arg. leaf extracts

Cited by 10 publications

References 17 publications

Biological Sciences and Biotechnology

Biological Sciences and Biotechnology

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Anti‐Helicobacter pylori, Anti‐Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans

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