Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Phuaklee, Pathompong; Dechayont, Bhanuz; Chunthorng-Orn, Jitpisute; Prajuabjinda, Onmanee; Juckmeta, Thana; Jiraratsatit, Kitrawee; Sukkasem, Kanmanee; Mokmued, Khwanchanok; Yangthaworna, Kitiya

doi:10.2306/scienceasia1513-1874.2021.089

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Compounds presented in the plant extracted with different polarity solvents exhibited a distinct biological action. Naturally occurring plant antioxidants, the phenolic compounds -polar molecules, were found to possess strong antioxidant activities [19,20]. The antioxidant capacity, the direct scavenge activity, of the extracts was evaluated using DPPH radical scavenging and ABTS radical scavenging assays.…”

Section: Discussionmentioning

confidence: 99%

Biological Sciences and Biotechnology

Seubsasana¹,

Dechayont²,

Pipatrattanaseree³

et al. 2023

ScienceAsia

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Diabetes mellitus (DM) is a chronic metabolic disorder associated with persistent hyperglycemia. Globally, the number of people with DM has quadrupled in the past three decades, and type 2 diabetes mellitus (T2DM) accounts for around 90% of all cases of diabetes. The role of oxidative stress is well established in T2DM pathogenesis. The synthetic drugs for T2DM are associated with serious side effects. Antioxidant and α-glucosidase inhibitory actions of phytochemicals from various plant species are considered an alternative to the synthetic drugs for T2DM management. This study aimed to evaluate the antioxidant activity, α-glucosidase inhibition, and phytochemical profiling of Belosynapsis ciliata. The total phenolic and flavonoid contents, antioxidant activity of 1,1-diphenyl-2picrylhydrazyl (DPPH) free radical, 2,2 -azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radical, and nitric oxide (NO) radical, and α-glucosidase inhibition of B. ciliata extracts were determined spectrophotometrically. The ethyl acetate extract form B. ciliata had highly potent scavenging activities for DPPH (EC 50 ; 80.02 ± 4.34 µg/ml) and ABTS (EC 50 ; 97.07 ± 1.52 µg/ml). Meanwhile, the dichloromethane extract possessed a good scavenging of NO (IC 50 ; 121.65 ± 3.48 µg/ml) and had the highest α-glucosidase inhibitory activity (IC 50 ; 33.28 ± 1.36 µg/ml). This study demonstrated the promising antioxidant activities, and α-glucosidase inhibitory action of B. ciliata was probably due to the presence of phenolic and flavonoid contents. The finding provided us with the leads to proceed with the development of medicinal plant having antidiabetic attributes.

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Section: Discussionmentioning

confidence: 99%

Biological Sciences and Biotechnology

Seubsasana¹,

Dechayont²,

Pipatrattanaseree³

et al. 2023

ScienceAsia

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“…[ 4 ] Albizia lucidior and Albizia lebbeck were used traditionally to manage fever. [ 5,6 ] Similarly, Albizia myriophylla was used to treat fever in Thai folk medicine. [ 7 ] Albizia julibrissin was used as an anti‐inflammatory agent in indigenous medicine whereas Albizia amara was implemented as an antimalarial therapy.…”

Section: Introductionmentioning

confidence: 99%

A comparative untargeted metabolomic analysis and assessment of antiplasmodial potential of nine Albizia species

El Khodary,

Ayoub,

Pério

et al. 2024

Archiv der Pharmazie

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The genus Albizia is one of the richest genera in phenolics besides other classes of secondary metabolites including saponins, terpenes, and alkaloids with promising medicinal applications. In the current study, UHPLC‐PDA‐ESI‐MS/MS‐based metabolic profiling of leaves of Albizia lebbeck, Albizia julibrissin, Albizia odoratissima, Albizia procera, Albizia anthelmintica, Albizia guachapele, Albizia myriophylla, Albizia richardiana, and Albizia lucidior resulted in the tentative identification of 64 metabolites, mainly flavonoids, phenolic acids, saponins, and alkaloids. Some metabolites were identified in Albizia for the first time and could be used as species‐specific chemotaxonomic markers, including: apigenin 7‐O‐dihydroferuloyl hexoside isomers, apigenin 7‐O‐pentosyl hexoside, quercetin 3‐O‐rutinoside 7‐O‐deoxyhexoside, quercetin 3,7‐di‐O‐hexoside deoxyhexoside, quercetin 7‐O‐feruloyl hexoside, methyl myricetin 7‐O‐deoxyhexoside, kaempferol di‐3‐O‐di‐deoxyhexoside‐7‐O‐hexoside, and kaempferol 3‐O‐neohesperidoside 7‐O‐hexoside. Comparative untargeted metabolomic analysis was undertaken to discriminate between species and provide a chemotaxonomic clue that can be used together with morphological and genetic analyses for more accurate classification within this genus. Moreover, the in vitro antiplasmodial activity was assessed and correlated to the metabolic profile of selected species. This was followed by a molecular docking study and absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction of the identified budmunchiamine alkaloids, revealing promising interactions with the active site of lactate dehydrogenase of Plasmodium falciparum and good pharmacokinetics and pharmacodynamics, which could help in designing novel antimalarial drugs.

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Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats

Zhang

Liu³

et al. 2022

Drug Development Research

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Postoperative Cognitive Dysfunction (POCD) is a neurological disorder of unconsciousness due to cognitive regression after surgical anesthesia. However, the specific mechanism has not yet been clarified. Sevoflurane (SEV) is one of the most commonly used anesthetics in clinical practice, and how SEV mediates the generation of POCD is unclear. Carnosol, a natural ingredient, has been reported to have various beneficial effects such as anti-inflammatory, immune enhancement, and so forth, but how it ameliorates SEV-mediated neurotoxicity remains unclear. This study aimed to induce a POCD model in aged rats by SEV and to elucidate how Carnosol ameliorated SEV-mediated neurotoxicity. The effects of Carnosol on the expression of inflammatory factors in rat hippocampus mediated by SEV were determined by enzyme-linked immunoassay and polymerase chain reaction experiments; the effects of Carnosol on the expressions of Iba-1 and glial fibrillary acidic protein after SEV-mediated activation of rat microglia were clarified by immunofluorescence and Western blotting (WB); The effects of Carnosol on SEVmediated neuronal apoptosis were studied by terminal deoxynucleotidyl transferase dUTP nick end labeling and WB; the specific signaling pathways regulated by Carnosol were elucidated by WB. The results showed that Carnosol can improve the cognitive dysfunction and reduce neuroinflammation in aged rats induced by SEV; Carnosol can reduce the activation of microglia and inhibit neuronal apoptosis in aged rats induced by SEV; Carnosol can phosphorylate p65 and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha regulates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Carnosol can attenuate SEV-induced neuroinflammation, prevent microglial activation and inhibit neuronal apoptosis by modulating the NF-κB pathway.

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Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Cited by 4 publications

References 20 publications

Biological Sciences and Biotechnology

Biological Sciences and Biotechnology

A comparative untargeted metabolomic analysis and assessment of antiplasmodial potential of nine Albizia species

Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats

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