Antinociceptive properties produced by the pregnane compound velutinol A isolated from Mandevilla velutina

From popular use to pharmacological validation: A study of the anti-inflammatory, anti-nociceptive and healing effects of Chenopodium ambrosioides extract

“…The results demonstrate that EE was statistically able to inhibit the pain induced by PGE 2 suggesting their participation in acute pain. In the model of nociception induced by BK, it was observed that only the dose of 500 mg/kg decreased pain threshold (Mattos et al, 2006). The anti-nociceptive effect of the extract was also observed in the model of pain induced by CAP.…”

“…The procedure for producing phgogen-induced nociception in mice was similar to that described previously (Mattos et al, 2006). Twenty microlitres of PGE 2 (3 nmol/paw), formalin (FORM, 2.5%), BK (10 nmol/paw), or CAP (1 nmol/paw), diluted in PBS solution, were injected intra-plantarly (i.pl.)…”

A Concise Total Synthesis of the Non‐peptide Bradykinin B1 Receptor Antagonist Velutinol A

“…[5] Further pharmacological studies showed that 1 has potent anti-inflammatory activity and behaves as a selective antagonist for the B1R subtype. [6] To the best of our knowledge, 1 is the first and only B1R antagonist among nonpeptide natural products to be published to date. A complex structural model of velutinol A bound to B1R was generated with the homology module by using a model of metarhodopsin photointermediates in the bovine rhodopsin photocascade as the template.…”

Pregnanos e outros constituintes das raízes de Macrosiphonia petraea (A. St.-Hil.) Kuntze (Apocynaceae)

“…8,9 A investigação fitoquímica de plantas deste gênero levou ao isolamento de glicosídeos cardíacos, pregnanos e triterpenos e à caracterização de substância com importante propriedade anti--inflamatória e antinociceptiva. 10 No gênero Macrosiphonia, a planta medicinal mais conhecida e estudada, para a qual são atribuídas diversas propriedades, destacando-se a atividade anti-inflamatória, é a M. velame, popularmente designada como velame-branco. 11 A espécie Macrosiphonia petraea, também designada pelas sinonímias Macrosiphonia petrea, Macrosiphonia verticillata var.…”