From popular use to pharmacological validation: A study of the anti-inflammatory, anti-nociceptive and healing effects of Chenopodium ambrosioides extract

TrivellatoGrassi, Liliane; Malheiros, Ângela; Meyre‐Silva, Christiane; Buss, Ziliani da Silva; Monguilhott, Eduardo Dalmarco; Fröde, Tânia Sílvia; Silva, Kathryn Ana Bortolini Simão da; Souza, Márcia María de

doi:10.1016/j.jep.2012.10.040

Cited by 87 publications

(60 citation statements)

References 39 publications

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“…The model involves the participation of several cell types and mediators [27]. The mouse pleural inflammatory response induced by carrageenan constitutes an inflammatory model characterized by two distinct phases: (1) 4 h after carrageenan injection and (2) 48 h after carrageenan injection.…”

Section: Discussionmentioning

confidence: 99%

Contribution ofα,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects ofAleurites moluccana(L.) Willd.

Quintão

Rocha

Silva

et al. 2014

BioMed Research International

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The aim of the study was to analyze the constituents of the dichloromethane fraction obtained from A. moluccana and also to evaluate the anti-inflammatory and antinociceptive properties of α,β-amyrenone isolated from A. moluccana in mice. The dichloromethane fraction was evaluated by gas chromatography and submitted to purification. The mixture of α,β-amyrenone was isolated and then evaluated using the carrageenan-induced paw-oedema or pleurisy and CFA-induced arthritis models in mice. Five triterpenes, α,β-amyrenone, glutinol, and α,β-amyrin were isolated from dichloromethane fraction of A. moluccana leaf extract. The mixture of α,β-amyrenone, dosed orally, was able to reduce mechanical hypersensitivity and paw-oedema induced by carrageenan, interfering with neutrophil migration. Similar results were observed in the carrageenan-induced pleurisy model. Repeated administration of the compounds was also effective in reducing the mechanical sensitization and oedema developed in the arthritis model induced by CFA. In conclusion, the results demonstrate that α,β-amyrenone interferes in both acute and chronic inflammatory processes. We can infer that these effects involve, at least in part, a reduction in the neutrophil migration. Therefore, it seems reasonable to suggest that α,β-amyrenone could represent a new therapeutic tool for the management of painful and inflammatory diseases, especially those presenting a chronic profile.

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Section: Discussionmentioning

confidence: 99%

Contribution ofα,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects ofAleurites moluccana(L.) Willd.

Quintão

Rocha

Silva

et al. 2014

BioMed Research International

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“…In addition, Chenopodium ambrosioides occupies the 17th position on the National Register of Plants of Interest to the National Health System (Relação Nacional de Plantas de Interesse do Sistema Único de Saúde - RENISUS), a list compiled by the Brazilian Government which consists of 71 plant species used in folk medicine for the alternative treatment of health conditions [13]. Experimental studies have shown that C. ambrosioides exerts immunostimulatory [14, 15], antimicrobial [16], anti-inflammatory and antinociceptive activities [17, 18]. …”

Section: Introductionmentioning

confidence: 99%

Chenopodium ambrosioides as a bone graft substitute in rabbits radius fracture

Neto

Ribeiro

Morais

et al. 2017

BMC Complement Altern Med

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BackgroundBone defects caused by trauma, infection or tumor resection are common in orthopedic clinic and depending on the extent of the fracture; the vast majority require treatment with bone substitutes. Among the bone grafts employees, the autograft is defined as the gold standard, but with some limitations, principally related to morbidity at the site of its removal, with the need to search for other biomaterials as adjuvant in bone regeneration. Therefore, the objective of the present study was to evaluate the use of Chenopodium ambrosioides as a bone graft substitute for the osseointegration of fractures in rabbits, compared to other bone grafts already employed in the surgical routine as Ricinus communis (castor oil) polyurethane and autogenous bone marrow.MethodsForty-eight rabbits were divided into four groups. After anesthesia, a radius fracture was created and the animals were treated with the following grafts: C. ambrosioides graft, autogenous bone marrow, castor oil and saline (control). After 30, 60 and 90 days, the animals were submitted to radiographical and histological analyses and bone alkaline phosphatase, osteocalcin, biomechanical tension, and collagen were measured. We also realized a phytochemical screening and in vitro antioxidant activity including 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical.ResultsThe data showed that the growth of the bone callus was more expressive and biomechanical assessment showed better tensile strength in C. ambrosioides graft. The experimental results also revealed that there was significantly greater activity of the bone alkaline phosphatase and osteocalcin during early fracture healing, similarly to the group receiving autogenous bone marrow. Histologically, immature bone was observed in C. ambrosioides graft at 30 days, whereas the formation of cartilaginous tissue predominated in the other groups. A higher amount of type I collagen was observed in C. ambrosioides graft throughout treatment. It was detected strong presence of flavonoids and appreciable antioxidant activity.ConclusionsThe results indicate that C. ambrosioides graft and autogenous bone marrow have similar ability to enhance bone regeneration, higher than the castor oil graft, suggesting that the medicinal plant can provide therapeutic benefits for bone tissue.

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“…These bioactive compounds generally exhibit anti-inflammatory activities, which indicate its use for preventing osteoporosis [22][23][24] .…”

Section: Discussionmentioning

confidence: 99%

Chenopodium ambrosioides L. extract prevents bone loss

Soares

Carvalho

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate the effect of the Chenopodium ambrosioides L (mastruz) extract for preventing bone loss and bone metabolism in ovariectomized rats. METHODS:Twelve rats were subjected to bilateral ovariectomy for inducing osteoporosis. After surgery, they were divided into two groups: Ovariectomy-control group (G1, n=6), receiving 0.5 ml distilled water by gavage for 30 days, and Ovariectomy plus mastruz group (G2, n=6), receiving 0.5 ml of the hydroalcoholic extract of mastruz at 10% concentration (50mg) daily, for the same period.Then, the blood of the animals was collected for further biochemical analysis (liver function) and tibia and liver were removed for histological and histomorphometric analyses. RESULTS:The cortical bone was significantly larger in the G2 than G1, whereas G1 presented the highest amount of adipocytes in the bone marrow (p<0.05). The blood levels of aspartate aminotransferase, triglycerides and cholesterol were significantly higher, whereas globulin and lactate dehydrogenase were smaller in G2 than G1. CONCLUSION:The hydroalcoholic extract of mastruz has effects on bone metabolism by changing blood proteins and enzymes and preventing both bone loss and the substitution of bone marrow cells by

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From popular use to pharmacological validation: A study of the anti-inflammatory, anti-nociceptive and healing effects of Chenopodium ambrosioides extract

Abstract: The results, including the inhibition of mediators (BK, NO, SP, PGE(2) and TNF-á) and enzyme (MPO and ADA) activity, validate the use of the plant under study for therapeutic treatment of anti-inflammatory, painful and wound healing processes.

Cited by 87 publications

References 39 publications

Contribution ofα,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects ofAleurites moluccana(L.) Willd.

Contribution ofα,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects ofAleurites moluccana(L.) Willd.

Chenopodium ambrosioides as a bone graft substitute in rabbits radius fracture

Chenopodium ambrosioides L. extract prevents bone loss

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