Antinociceptive activity of Mirabilis jalapa in mice

Walker, Cristiani Isabel Banderó; Trevisan, Gabriela; Rossato, Mateus; Franciscato, Carina; Pereira, Maria Estér; Ferreira, Juliano; Manfron, Melânia Palermo

doi:10.1016/j.jep.2008.08.002

Cited by 54 publications

(34 citation statements)

References 22 publications

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“…After administration, the animals were kept in separate cages and were allowed to food and water ad libitum. The animals were then observed for possible behavioral changes, allergic reaction (skin rash, itching) and mortality for the next 72 h [21].…”

Section: Acute Toxicity Testmentioning

confidence: 99%

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

2018

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Background: Commelina diffusa Burm. (Family: Commelinaceae) is usually known as "climbing dayflower or spreading dayflower" in Bangladesh. The plant is used in fever, malaria, insect, bug bites, rheumatoid arthritis, gonorrhea, influenza, and bladder infection etc. The present investigation was undertaken which deals with the evaluation of central nervous system (CNS) depressant activity of methanolic extract of C. diffusa in mice models.

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Section: Acute Toxicity Testmentioning

confidence: 99%

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

2018

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“…www.antiox.org materials were dried in shade and powdered in a mechanical grinder. The powder(100gm) of the root and aerial parts each were initially de-fatted with petroleum ether (60-80°C), followed by 500ml methanol by Soxhlet extraction method for 72 hrs separately .Solvent elimination under reduced pressure afforded the petroleum ether and methanol extract of which methanol extract was further used for antioxidant assay methods [12], [13], [14] . The extract was dried in a vacuum desiccator to obtained constant weight.…”

Section: Introductionmentioning

confidence: 99%

In-vitro Antioxidant Potential of Methanolic Extracts of Mirabilis jalapa Linn

Zachariah

Aleykutty

Viswanad

et al. 2011

Free Radicals and Antioxidants

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“…Then they caged separately and provided free excess to food and water. They were observed for the next three days (Imam and Sumi, 2014;Walker et al, 2008) for possible changes in the behavior, allergic reactions (like skin rash, itching) and mortality.…”

Section: Acute Oral Toxicity Testingmentioning

confidence: 99%

Potential evaluation of central nervous system anti-depressant activity of Cleome rutidosperma in mice

Archi¹,

Islam²,

Babu³

et al. 2016

Biomed Res Ther

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Introduction: This investigation was carried out to analyze the central nervous system (CNS) depressant effect of the plant Cleome rutidosperma extract, after it was found to have been used by the local people in the Philippine for that purpose. Methods: In this study presented below, the CNS depressant effects of the extract was evaluated in in vivo mice models; using the standard procedures of Open field, Hole cross and Thiopental sodium induced sleeping time tests. Results: Using two test extracts at a concentration of 100 and 200 mg/kg, it was seen that the extracts showed significant (p< 0.01) dose dependent suppression of motor activity in both open field and hole cross test, 4.67 ± 0.68 ** and 3.00 ± 0.45 ** , respectively at 200 mg/kg. It also showed significant (p< 0.01) decrease in the time for the onset of sleep (5.00 ± 0.45 at 200 mg/ kg); and an increase in sleeping duration (70.20 ± 0.66 at 200 mg/kg), when compared with the positive control Thiopental sodium. Conclusion: Overall, the study demonstrates that the extracts used, showed promising CNS depressant effect. Further study needs to be carried out on the extract to isolate the active constituent, so that it can be assessed for therapeutic use.

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Antinociceptive activity of Mirabilis jalapa in mice

Cited by 54 publications

References 22 publications

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

In-vitro Antioxidant Potential of Methanolic Extracts of Mirabilis jalapa Linn

Potential evaluation of central nervous system anti-depressant activity of Cleome rutidosperma in mice

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