Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Sultana, Tania; Mannan, Md. Abdul; Ahmed, Tasnia

doi:10.1186/s40816-018-0063-1

Cited by 23 publications

(23 citation statements)

References 23 publications

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“…Consequently, it is anticipated that the extract may potentiate GABAergic inhibition in the CNS via membrane hyper polarization of critical neurons in the brain or it may directly activate GABA receptors. It may enhance affinity for GABA or an increase in the duration of the GABA-gated channel opening [15].…”

Section: Discussionmentioning

confidence: 99%

Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice

et al. 2019

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Background: Recently, medicinal plants have grabbed attention worldwide in the field of neurosciences for therapeutic intervention. Traditionally, Ceriscoides turgida is used to treat scorpion string, epilepsy, stomachache etc. Present study was designed to peruse neuropharmacological properties of leaf and root extract of C. turgida. Methods: The neuropharmacological activities were examined by thiopental sodium induced sleeping time, hole cross, hole board and open field tests in mice at the doses of 100 mg/kg and 200 mg/kg body weight. Results: All the extracts exhibited significant reduction of onset and duration of sleep in thiopental sodium induced sleeping time test. Besides, significant reduction of spontaneous locomotor and exploratory activities was found in both hole cross and open field test. Furthermore, both extracts also decreased the number of head dips by mice in hole-board test. Conclusion: Altogether, these results suggest that experimental extracts of C. turgida possesses potent CNS depressant and hypnotic properties, which support its use in traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice

et al. 2019

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“…Figure (3 and 4) showed reduction in immobility duration in a dose dependent manner at 125 and 250 mg/kg however duration of immobility was increased at a dose of 500 mg/kg which indicates its depressive effect and it could be due to the presence saponins in high levels in the SCME [27]. Role of saponins was reported in various studies as CNS depressant due to its agonistic response on GABA-A receptor complex [28,29]. Hence therapeutic levels of drug concentration can be achieved by the adjustment of dose.…”

Section: Discussionmentioning

confidence: 86%

“…Variables estimated were (1) Immobility duration, (2) Climbing duration and (3) Swimming duration. 28 SCME, vehicle and imipramine were administered daily through oral route over a period of 14 days and then animals were exposed to pre-test session after 14 days of treatment. Once again animals were placed in the same condition for 5 min (test session) after 24 h of the pre-test session.…”

Section: Forced Swimming Testmentioning

confidence: 99%

Screening of Anxiolytic and Antidepressant of Methanolic Leaves Extract of Syzygium Cumini in Mice

Rehman

Riaz

Asghar

et al. 2020

RADS J. Pharm. Pharm. Sci.

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Background: Anxiety and depression are very common in clinical practice and reduce the overall quality of life. In recent years, various researchers have focused on natural products which are derived from medicinal plants. Studies suggested that diet rich in flavonoids, vitamins and antioxidants are the important components in reduction of anxiety and depression. Objective: Hence current investigation was aimed to assess the anxiolytic and antidepressant effects of Syzygium cumini in mice at 125, 250 and 500 mg/kg. Methods: These effects were mainly evaluated twice at 8th and 15th days by elevated plus maze, open field test, forced swimming test and tail suspension test. Results and Conclusion: In open field test S. cumini showed escalation rearing in numbers and its duration which indicates improved exploratory behavior and locomotor activity of the animals. In EPM, there was increase in entries numbers and time spent in open arm. Decrease in immobility duration observed at low dose while high dose increased immobility duration in FST. Hence outcomes of current study indicate that S. cumini have anxiolytic and anti-depressant effect.

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“…Because during active locomotion, excitatory feedback is supplied by sensory afferent neurons to spinal interneuron and motor neuron in regards to muscle constriction [ 59 ]. This feedback pathway is further inhibited by GABAergic interneuron through an allosteric moderation of GABA receptors and thus induces CNS depressant effect [ 61 ]. As reported by many researchers, open field and hole cross tests are the classic animal models to evaluate the instinctive activity of experimental mice [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

An integrated exploration of pharmacological potencies of Bischofia javanica (Blume) leaves through experimental and computational modeling

Chowdhury

Hanif

et al. 2020

Heliyon

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Bischofia javanica (Blume), an edible wild plant, has both prospective nutraceutical and therapeutic properties. Here, we intended to explore the pharmacological potentials of the methanol extract of B. javanica (MEBJ) through integrated approaches. Phytochemical screening revealed the presence of important phytoconstituents which were found to be safe during cytotoxicity analysis. The sedative potential of MEBJ (200 and 400 mg/kg) was determined by employing open field, hole cross, and thiopental sodium-induced sleeping time tests, where a significant reduction of the locomotor performance and an enhancement in the duration of sleeping have been observed, respectively. In addition, mice treated with MEBJ exhibited superior exploration during both elevated plus maze and hole board tests. In parallel, anti-diabetic potency was investigated via alpha-amylase inhibitory assay, where a dose-response increase in the percentage of inhibition has been marked. A similar response, such as an increased percentage of clot lysis, was observed during the thrombolytic test. Furthermore, molecular docking was performed with the identified compounds, demonstrated strong binding affinities to the target receptors of the experiments as mentioned above. Also, ADME/T and toxicological parameters verified the drug-like properties of the identified compounds. Collectively, these results indicate bioactivity of Bischofia javanica , which can be a potential candidate in the food and pharmaceutical industries.

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Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Cited by 23 publications

References 23 publications

Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice

Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice

Screening of Anxiolytic and Antidepressant of Methanolic Leaves Extract of Syzygium Cumini in Mice

An integrated exploration of pharmacological potencies of Bischofia javanica (Blume) leaves through experimental and computational modeling

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