Screening of Anxiolytic and Antidepressant of Methanolic Leaves Extract of Syzygium Cumini in Mice

Rehman, Ahad Abdul; Riaz, Azra; Asghar, Muhammad Arif; Sikandar, Bushra; Baig, Moona

doi:10.37962/jpps.v8i2.368

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…In Table S6 and S7 families, there are two plants with the potential to overcome health disorders, namely Syzygium aromaticum and Syzygium cumini (Myrtaceae), as well as Piper methysticum L. and Piper nigrum Linn. (Piperaceae) (Rehman et al, 2020;P. Tiwari et al, 2014;Emon et al, 2021).…”

Section: Scientific Evidence Indonesian Medicinal Plants Overcome Men...mentioning

confidence: 99%

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Indonesian Indonesian Medicine Plants for Mental Health Disorders: Anxiety and Depression

Wati,

Batubara,

Arifin

et al. 2024

Indonesian J Pharm

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Mental health disorders are currently widely discussed, especially anxiety and depression. The number of people living with anxiety and depression disorders in 2020 increased significantly due to the COVID-19 pandemic. These mental health disorders are quite serious and need to be addressed. Indonesian people for generations have used medicinal plants in everyday life, one of which is to treat symptoms of mental health disorders such as increasing mood and motivation, calming, overcoming depression, stress, anxiety, and sleep disorders. However, there has been no comprehensive review on the ethnopharmacology of Indonesian medicinal plants that can treat mental health disorders such as depression and anxiety and there is also little scientific evidence to support the efficacy of these plants. This paper reviews Indonesian medicinal plants used to treat mental health disorders and reviews the scientific evidence for these plants. We conduct literature studies of scientific articles, research journals, and books at national and international vessels. The search results identified 67 Indonesian medicinal plants used to treat symptoms of mental health disorders. The Zingiberaceae family is reported as the most medicinal plant that can potentially treat mental health disorders such as depression and anxiety. Several plants have been proven in preclinical research, but many still have not been studied and proven. Therefore, further research on Indonesian medicinal plants that can overcome mental health disorders must be carried out to provide knowledge and develop drugs for mental health disorders.

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Section: Scientific Evidence Indonesian Medicinal Plants Overcome Men...mentioning

confidence: 99%

“…Tiwari et al, 2014;Emon et al, 2021). S. aromaticum has antianxiety activity, while S. cumini possesses antidepressant, antianxiety, and sedative effects (Galal and Abdellatief 2015;Rehman et al 2020). P. nigrum Linn.…”

Section: Scientific Evidence Indonesian Medicinal Plants Overcome Men...mentioning

confidence: 99%

Indonesian Indonesian Medicine Plants for Mental Health Disorders: Anxiety and Depression

Wati,

Batubara,

Arifin

et al. 2024

Indonesian J Pharm

View full text Add to dashboard Cite

show abstract

“…intrinsic renal azotemia, prerenal azotemia and postrenal azotemia [2]. Recently, many studies reported the significant pharmacological activities of different plant extracts [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CCl4 induced renal injury in rats

Burki

Asghar

et al. 2021

BMC Complement Med Ther

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Background Degenerative kidney diseases are mostly associated with oxidative stress. Natural products are considered as the antioxidants enrich food that can restrict the progress of oxidative stress induced disorders. Therefore, the present study was aimed to evaluate the renal protective effect of Ajuga parviflora leaf extract in carbon tetrachloride intoxicated rats. Methods The hydromethanolic extract of A. parviflora leaves was obtained by extracting twice in 60% methanol. The principal bioactive constituents were detected by LC/MS analysis. Toxicity of plant extract was assessed using brine shrimp lethal toxicity test and acute toxicity model on healthy Sprague-Dawley male rats. Nephroprotective effects of plant extract were also evaluated on rats by inducing CCl4 renal toxicity in comparison with positive control and naïve groups. The dose of A. parviflora administered to animal was 100, 200 and 300 mg/kg. All administrations were given orally on an alternate day basis for 30 days. Urine and serum biomarkers were analyzed, along with antioxidant enzymes. Finally, the DNA damages, lipid peroxides, hydrogen peroxides and nitrites were assessed in rat’s renal tissue. The histopathology alterations in renal tissues were further studied for kidney damages. Results The LC/MS analysis confirmed the presence of different important pharmacological compounds in A. parviflora methanolic leaf extract. The key bioactive compounds include pyocyanin, zonisamide, D Saccharic acid, altretamine, carbocyclic thromboxane A2, Sinapyl alcohol, and vitamin C. The important polypeptides identified include Lys-Tyr-Lys, His-His-Lys, Met-Asp-Arg, Phe-Val-Arg, and PyroGlu-Val-Arg. The LD50 of A. parviflora was found to be > 1000 μg/mL. A. parviflora administration significantly subsides CCl4 toxicity in rats, reduced the elevated level of RBCs, pus and epithelial cells. The abnormal elevated level of specific gravity, creatinine, urobilinogen, urea and albumin were also reduced to normal physiological level. The reduced urinary protein and pH were also normalized. The serum urobilinogen, urea and total bilirubin levels were also reversed to normal levels while the diminished albumin and total protein levels also came to normal. The important phase I and II enzyme levels were also reversed in A. parviflora administered rats. The H2O2, thiobarbituric acid reactive substance (TBARS) and nitrite levels were significantly decreased. Furthermore, the damaged DNA and histopathological changes in CCl4 exposed rats were also highly significantly reversed after the administration of A. parviflora. All effects were significant (P < 0.05) and highly significant (P < 0.005) at 100 and 300 mg/kg respectively. Conclusion The restored urine and serum profile of various parameters to normal physiological levels suggests that the A. parviflora has potential antioxidant and repairing potential in renal disorders.

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Screening of Anxiolytic and Antidepressant of Methanolic Leaves Extract of Syzygium Cumini in Mice

Cited by 2 publications

References 25 publications

Indonesian Indonesian Medicine Plants for Mental Health Disorders: Anxiety and Depression

Indonesian Indonesian Medicine Plants for Mental Health Disorders: Anxiety and Depression

Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CCl4 induced renal injury in rats

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