2020
DOI: 10.3389/fphar.2020.00777
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Abstract: Introduction: Pain is considered an unpleasant sensory and emotional experience, being considered as one of the most important causes of human suffering. Computational chemistry associated with bioinformatics has stood out in the process of developing new drugs, through natural products, to manage this condition. Objective: To analyze, through literature data, recent molecular coupling studies on the antinociceptive activity of essential oils and monoterpenes. Data source: Systematic search of the literature c… Show more

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Cited by 17 publications
(7 citation statements)
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References 113 publications
(167 reference statements)
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“…Similarly, in this docking work interactions at Val76 and Leu125 were detected. In another experimental study, the natural agonist of LasR, OdDHL, was also found to have hydrogen bonds at Trp60 and Ser129 as in TP-1 [29]. These studies supported the docking results reported here.…”
Section: Discussionsupporting
confidence: 84%
“…Similarly, in this docking work interactions at Val76 and Leu125 were detected. In another experimental study, the natural agonist of LasR, OdDHL, was also found to have hydrogen bonds at Trp60 and Ser129 as in TP-1 [29]. These studies supported the docking results reported here.…”
Section: Discussionsupporting
confidence: 84%
“…It is a predictive model that assists in the evaluation of the pharmacological activity of a substance based on in vivo tests. 29,30 The choice of models for the analysis of orofacial antinociceptive effect in this study considered neuroanatomical aspects of capture, path, and processing of information about the face region, more specifically about the trigeminal nerve. This model was used for behavior analysis in inflammatory conditions: changes in spontaneous grooming behavior.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, we reinforce the notion that other receptors distinct from dTRPA1 may mediate part of the aversive responses of D. melanogaster to citronellal. These include the olfactory coreceptor OR83b [11], and potentially, 5-HT and GABA receptors [47][48][49].…”
Section: Discussionmentioning
confidence: 99%