Antimullerian hormone and obesity: insights in oral contraceptive users

Steiner, Anne Z.; Stanczyk, Frank Z.; Patel, Sumit; Edelman, Alison

doi:10.1016/j.contraception.2009.10.004

Cited by 102 publications

(95 citation statements)

References 19 publications

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“…In this respect, various results have been reported regarding the impact of steroid suppression on serum AMH levels. Some studies reported null effect of OCP treatment on serum AMH levels [18,21,22], whereas others revealed suppressed AMH levels in normal cycling women pretreated with OCP [1,15]. In a recent case report it was demonstrated that during 16 week course of menotropin treatment both serum AMH and AFC increased in an IHH patient.…”

Section: Discussionmentioning

confidence: 99%

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Sönmezer

Özmen

Atabekoglu

et al. 2012

J Assist Reprod Genet

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Purpose The role of serum AMH levels in prediction of ovarian response in idiopathic hypogonadotropic hypogonadism (IHH) was evaluated. Material method(s) Twelve patients with IHH underwent controlled ovarian hyperstimulation (COH) for IVF were enrolled in this prospective study. Serum AMH levels were studied on the 2nd or 3rd day of an induced menstrual cycle by a preceding low-dose oral contraceptive pill treatment. A fixed dose (150-300 IU/day) of hMG was given in all COH cycles. Correlations between serum AMH levels, COH outcomes and embryological data were investigated. Results Mean serum AMH levels was 3.47±2.15 ng/mL and mean serum peak estradiol was 2196±1705 pg/mL. Mean number of follicles >14 mm, >17 mm on hCG day and MII oocytes were 4.14±3.2, 4±2.5 and 7.28±3.5, respectively. Mean number of grade A embryos and transferred embryos were 3.28 ± 2.4 and 2.5 ± 0.7, respectively. The clinical pregnancy rate per patient was 41.6 % (5/12). Positive correlations were observed between serum AMH levels and MII oocytes (r00.84), grade A embryos (r00.85), serum peak estradiol levels (r00.87), and number of follicles >14 mm (r00.83) and >17 mm (r00.81) on hCG day, respectively. Conclusion AMH appears as a promising marker of ovarian response in patients with IHH undergoing IVF.

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Section: Discussionmentioning

confidence: 99%

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Sönmezer

Özmen

Atabekoglu

et al. 2012

J Assist Reprod Genet

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“…A number of studies have evaluated the association between AMH and BMI [11,[14][15][16][17][18][19][20][27][28][29][30][31]. (Table 4) These study results can be classified under two groups: (1) studies which suggest presence of a negative correlation between AMH levels and BMI, (2) studies which suggest that there is no correlation between BMI and AMH levels.…”

Section: Discussionmentioning

confidence: 99%

Serum anti‐müllerian hormone concentrations in reproductive age women with and without polycystic ovary syndrome: the influence of body mass index

Şahmay

Güralp

Şentürk

et al. 2011

Reprod Medicine & Biology

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Purpose To evaluate the correlation between anti-mülle-rian hormone (AMH) and body mass index (BMI) in patients with and without polycystic ovarian syndrome (PCOS). Methods Serum AMH levels of 332 women in their reproductive period and below 45 years of age who were admitted to our reproductive endocrinology clinic with infertility were investigated in a cross-sectional study. Patients were divided into two groups as BMI under and equal or over 25 kg/m 2 . Both groups were divided into two subgroups as PCOS and non-PCOS. AMH levels of patients were analyzed for each group. Results Mean AMH values of BMI \25 and C25 kg/m 2 groups were 3.87 ± 2.95 and 3.58 ± 2.93 ng/mL, respectively (P [ 0.05) in all patients. Means of AMH were not significantly different in BMI quartiles (r = -0.008401, P = 0.96). Among 107 patients with PCOS, means of AMH were 6.85 ± 2.95 ng/mL in 56 patients with BMI \25 kg/m 2 and 6.66 ± 3.18 ng/mL in 51 patients with BMI C25 kg/m 2 (P [ 0.05). In the group of 225 non-PCOS patients, means of AMH were 2.27 ± 1.12 ng/mL in 104 patients with BMI\25 kg/m 2 and 2.28 ± 1.49 ng/mL in 121 patients with BMI C25 kg/m 2 (P [ 0.05). Conclusions Body mass index does not seem to have an effect on serum AMH levels in reproductive age women both with and without PCOS.

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“…Because recent findings suggested an influence of OC-use on AMH levels, we adjusted for OC-use in model 1 (23). In the second model, we additionally corrected for FM (kg) (model 2) because obesity has been previously related to serum AMH levels (24). Thirdly, we added age at menarche to the model (model 3), and finally SES was added (model 4).…”

Section: Discussionmentioning

confidence: 99%

Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women

Kerkhof

Leunissen

Willemsen

et al. 2010

European Journal of Endocrinology

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Background/objectives: Preterm birth has been associated with reduced reproduction rates, and controversies remain regarding the effect of being born small for gestational age (SGA) on ovarian function. Recent findings in young men showed no effect of preterm and SGA birth on testis function. We hypothesised that follicle pool size in young adult women is also not affected by preterm and SGA birth. Design/methods: In 279 young women of the PROGRAM/PREMS study, aged 18-24 years, the influence of gestational age, birth length and birth weight on serum levels of anti-Mü llerian hormone (AMH) was analysed with multiple regression modelling. Additionally, AMH levels were analysed in preterm-versus term-born females and in three subgroups: females born SGA with either short stature or catch-up growth (SGA-CU), and females born term and appropriate for gestational age with normal stature (AGA controls). Results: Preterm and SGA birth did not affect AMH and other hormone levels. Older age at menarche and oral contraceptive pill use (OC-use) were related to lower AMH levels, and maternal smoking during gestation was related to higher AMH levels. After correction for maternal smoking, lower socioeconomic status (SES) was associated with lower AMH levels. In subgroup comparisons, SGA-CU women showed higher AMH levels than AGA controls, also after adjustment for several factors. Conclusion: Preterm and SGA birth did not affect AMH levels. Factors associated with serum AMH levels were OC-use, age at menarche, maternal smoking during gestation and SES. We conclude that preterm-and/or SGA-born females are not likely to have a reduced follicle pool size.

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Antimullerian hormone and obesity: insights in oral contraceptive users

Cited by 102 publications

References 19 publications

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Serum anti‐müllerian hormone concentrations in reproductive age women with and without polycystic ovary syndrome: the influence of body mass index

Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women

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