Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Abstract

Purpose The role of serum AMH levels in prediction of ovarian response in idiopathic hypogonadotropic hypogonadism (IHH) was evaluated. Material method(s) Twelve patients with IHH underwent controlled ovarian hyperstimulation (COH) for IVF were enrolled in this prospective study. Serum AMH levels were studied on the 2nd or 3rd day of an induced menstrual cycle by a preceding low-dose oral contraceptive pill treatment. A fixed dose (150-300 IU/day) of hMG was given in all COH cycles. Correlations between serum AMH levels, COH outcomes and embryological data were investigated. Results Mean serum AMH levels was 3.47±2.15 ng/mL and mean serum peak estradiol was 2196±1705 pg/mL. Mean number of follicles >14 mm, >17 mm on hCG day and MII oocytes were 4.14±3.2, 4±2.5 and 7.28±3.5, respectively. Mean number of grade A embryos and transferred embryos were 3.28 ± 2.4 and 2.5 ± 0.7, respectively. The clinical pregnancy rate per patient was 41.6 % (5/12). Positive correlations were observed between serum AMH levels and MII oocytes (r00.84), grade A embryos (r00.85), serum peak estradiol levels (r00.87), and number of follicles >14 mm (r00.83) and >17 mm (r00.81) on hCG day, respectively. Conclusion AMH appears as a promising marker of ovarian response in patients with IHH undergoing IVF.

Oocyte quality in women with thalassaemia major: insights from IVF cycles

“…Previous studies on ovarian function and TM mainly focused on ovarian reserve and generally supported an impairment: AMH and AFC are consistently lower [4,[7], [8], [9], [10], [11]]. Our data is in agreement with these findings since both biomarkers resulted reduced in exposed women.…”

“…Recent studies also revealed that patients with TM have lower levels of anti-Mullerian hormone (AMH) and reduced antral follicular count (AFC), suggesting that the peripheral excess of iron may also be toxic locally to the gonads, harming the ovarian reserve [4,[7], [8], [9], [10], [11]]. In addition, iron excess, in particular non-transferrin-bound iron and its redox active form, may actually impact on oocyte quality.…”

Infertility treatment strategy involving combined freeze‐all embryos and single vitrified‐warmed embryo transfer during hormonal replacement cycle for in vitro fertilization of women with hypogonadotropic hypogonadism

“…Women with HH have abnormalities in the HPG axis and ovarian function but have age‐dependent dormant follicles in their ovaries . Theoretically, optimal physiological activation of ovarian follicles via gonadotropin administration can induce the development of single follicles and prevent multiple pregnancies and OHSS.…”

“…Therefore, women with HH show symptoms of hypoestrogenism, ovulation disorders and amenorrhea. However, according to the data of an ovarian function biomarker, anti‐Müllerian hormone, most women with HH have age‐dependent ovarian reserve . Therefore, optimal induction of gonadotropin secretion by pulsatile GnRH or continuous gonadotropin administration may improve folliculogenesis and ovulation, leading to improving pregnancy rates theoretically .…”

Pregnancy outcome of assisted reproductive technology cycle in patients with hypogonadotropic hypogonadism

“…AMH may be useful to some extent. [ 4 ] Ovaries may or may not be seen on USG in these patients. Only after a patient is subjected to gonadotropin stimulation, we can estimate her pattern of response.…”