Antimicrobial, antioxidant and anticancer activities of &lt;i&gt;Strychnos lucida&lt;/i&gt; R. Br.

Sarmento, N Da Costa; Worachartcheewan, A; Pingaew, R; Prachayasittikul, S; Ruchirawat, S; Prachayasittikul, V

doi:10.4314/ajtcam.v12i4.18

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…It has been reported to modify enzymatic activities and immune response pathways. A study by Moustafa et al showed an up-regulation in gene expression of IL-1β and TNF-α , reduced levels of aspartate aminotransferase (AST), and alanine aminotransferase (ALT), and increased resistance against A. hydrophila after administration of 3% fenugreek seed powder in Nile tilapia [ 86 , 87 ].…”

Section: The Effect Of Herbal Extracts and Plant Components On Immune-related Genes In Fish Speciesmentioning

confidence: 99%

The Gene Regulatory Roles of Herbal Extracts on the Growth, Immune System, and Reproduction of Fish

Ahmadifar

Fallah

Yousefi

et al. 2021

Animals

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The crucial need for safe and healthy aquatic animals obligates researchers in aquaculture to investigate alternative and beneficial additives. Medicinal herbals and their extracts are compromised with diverse effects on the performances of aquatic animals. These compounds can affect growth performance and stimulate the immune system when used in fish diet. In addition, the use of medicinal herbs and their extracts can reduce oxidative stress induced by several stressors during fish culture. Correspondingly, aquatic animals could gain increased resistance against infectious pathogens and environmental stressors. Nevertheless, the exact mode of action where these additives can affect aquatic animals’ performances is still not well documented. Understanding the mechanistic role of herbal supplements and their derivatives is a vital tool to develop further the strategies and application of these additives for feasible and sustainable aquaculture. Gene-related studies have clarified the detailed information on the herbal supplements’ mode of action when administered orally in aquafeed. Several review articles have presented the potential roles of medicinal herbs on the performances of aquatic animals. However, this review article discusses the outputs of studies conducted on aquatic animals fed dietary, medicinal herbs, focusing on the gene expression related to growth and immune performances. Furthermore, a particular focus is directed to the expected influence of herbal supplements on the reproduction of aquatic animals.

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Section: The Effect Of Herbal Extracts and Plant Components On Immune-related Genes In Fish Speciesmentioning

confidence: 99%

The Gene Regulatory Roles of Herbal Extracts on the Growth, Immune System, and Reproduction of Fish

Ahmadifar

Fallah

Yousefi

et al. 2021

Animals

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“…Furthermore, some researches had proven that different parts of this species showed different activities. The leaf is potential for antibacterial, that against Staphyloccocus aureus [6] and anticancer activity against MOLT-3 cells [7], the seed showed has antibacterial activity against S. aureus ATCC 25923 and Salmonella thypi [8], the wood of this species is potential for antimalarial [1] and antimicrobial against Bacillus subtilis ATCC 6683, B. cereus and S. pyogenes; the stem bark showed has an antioxidant and anticancer activity that inhibited MOLT-3 cells [7].…”

Section: Introductionmentioning

confidence: 99%

“…Previous publications have reported that the chemical components that had been found in S. ligustrina were triterpenoids [1,7,8], phenolics [1,7], tannins, alkaloids [1,8] such as strychnine and brucine, and flavonoids [1]. However, the composition of the compounds of medicinal plants in one species may depend on several factors, i.e.…”

Section: Introductionmentioning

confidence: 99%

Chemical components of different parts of Strychnos ligustrina, a medicinal plant from Indonesia

Rahayu¹,

Prihantini²,

Krisnawati³

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Strychnos ligustrina Blume is one of the potential plants for medicine that has been used by the local community in Indonesia for traditional medicine. Some studies showed that S. ligustrina parts had different activities, such as antimalarial, antibacterial, antimicrobial, antioxidant, and anticancer activities. Triterpenoids, phenolics, tannins, alkaloids, and flavonoids were detected in this species. Different plant parts and grow sites may affect the composition of chemical components. Therefore, the present study investigated the chemical components in different parts of S. ligustrina from some grow sites. The chemical components of different plant parts were analyzed by GC-MS and showed 51 compounds in total. The major constituents identified as mome inositol, heptadecene-(8)-carbonic acid-(1), palmitic acid, quinic acid, and stearic acid. The main active constituent of the antimalarial drug, strychnine, was also detected in this study. The PCA and cluster analysis of chemical components resulted in distinguished plant parts into three groups, whereas had shown no difference among the sites. In addition, the crucial compounds of this species that potential for antimalarial, strychnine, are only found in the leaf and stem. It has been shown that the leaf and stem are potential plant parts for the antimalarial agent.

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“…Songga wood (S. ligustrina) is a natural ingredient with antibiotic content that is used as a malaria drug by most people of Bima, West Nusa Tenggara and Bali, in addition songga wood is also used to treat diabetes and high blood. Sarmento et al (2015) research suggests that songga wood (S. ligustrina) Has antimicrobial, antioxidant, and anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Strychnos ligustrina Bl. Extract as Feed Supplementation to Increase Immune System of Nile Tilapia (Oreochromis niloticus) wich againts Streptococcus agalactiae

Zubaidah¹,

Faidah²,

Samsundari

2018

IJOTA

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One of the problems of intensive cultivation of tilapia is the attack of Streptococcosis disease caused by Streptococcus agalactiae bacteria. To prevent it is necessary to prevent the use of natural antibiotics that is Strychnine bush extract. The method used in this research is the experimental method using Completely Randomized Design (RAL), then the data is analyzed by using ANAVA. In this research, there were five treatments with various dosages, namely treatment (K: 0%), (A: 5%), (B: 10%), (C: 15%) and (D: 20%), each treatment was repeated four times. The main parameters used are hematocrit level, leukocrit level, leukocyte count and phagocytosis activity. As a supporting parameter is water quality and MIC (Minimum Inhibitation Concentration) test. The results showed that dosage of Strychnine bush extract did not affect the level of hematocrit and leukocrit level, but significant effect on leukocyte count with the highest value at treatment B with 10% dose is 11,9 × 105 cell / mm3. Giving extract also significant effect on phagocytosis activity with the highest phagocytosis value at treatment B with dose of 10% that is 32%.Keywords: Imune system, Streptococcosis, antibiotics, Minimum Inhibitation Concentration

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Antimicrobial, antioxidant and anticancer activities of <i>Strychnos lucida</i> R. Br.

Cited by 5 publications

References 15 publications

The Gene Regulatory Roles of Herbal Extracts on the Growth, Immune System, and Reproduction of Fish

The Gene Regulatory Roles of Herbal Extracts on the Growth, Immune System, and Reproduction of Fish

Chemical components of different parts of Strychnos ligustrina, a medicinal plant from Indonesia

Effectiveness of Strychnos ligustrina Bl. Extract as Feed Supplementation to Increase Immune System of Nile Tilapia (Oreochromis niloticus) wich againts Streptococcus agalactiae

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