Antimicrobial Activities of Malaysian Plant Species

Chung, Pooi Yin; Chung, Lip Yong; Ngeow, Yun Fong; Goh, S. H.; Imiyabir, Zamrie

doi:10.1080/13880200490511837

Cited by 58 publications

(51 citation statements)

References 7 publications

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“…Previously, we have reported G-protein coupled receptor binding and antimicrobial activities of some Malaysian plants and isolated compounds in our ongoing screening programme (Chung et al, 2004(Chung et al, , 2005a(Chung et al, , 2005b(Chung et al, , 2006(Chung et al, , 2008. In the current study we evaluated LOX inhibiting activity of Malaysian plants using a microplatebased ferric oxidation of xylenol orange (FOX) assay.…”

Section: Introductionmentioning

confidence: 99%

Lipoxygenase inhibiting activity of some Malaysian plants

Chung

Soo

Chan

et al. 2009

Pharmaceutical Biology

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Section: Introductionmentioning

confidence: 99%

Lipoxygenase inhibiting activity of some Malaysian plants

Chung

Soo

Chan

et al. 2009

Pharmaceutical Biology

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“…The antimicrobial activities of the synthesized compounds were tested using the disk-diffusion method 41 . A plate of 90 mm diameter containing the Muller-Hinton agar for the growth of bacteria and the sabouraud dextrose agar for the growth of fungi were prepared and each plate was separately inoculated with different cultures of the test bacteria and fungi by swabbing aseptically on the whole surface of the agar with cotton wool.…”

Section: Antimicrobial Assessment Methodologymentioning

confidence: 99%

Syntheses of Enaminone-Based Heterocyclic Compounds and Study their Biological Activity

Azab¹,

Break²,

El-Zahrani³

2016

Orient. J. Chem

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We herein reported the utility of 3-(3-(dimethylamino)acryloyl)-2H-chromen-2-one (2), as a versatile precursor for the synthesis of some new azole systems of possible biological activities. The structure of the newly synthesized compounds has been confirmed by IR, 1 H NMR, mass spectral and elemental analysis. Furthermore, some selected compounds were screened in vitro for their anti-microbial activities. The results declared that most of the synthesized compounds have high anti-microbial activity.

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“…As part of our ongoing research on the antimicrobial activities of Brazilian plants and bioactive natural compounds (Oliveira et al, 2007;Silva et al, 2007;Cunha et al, 2007), and because previous reports documenting the antimicrobial activity of Verbenaceae species against oral pathogens (Chung et al, 2004;Botelho et al, 2007), we have investigated the in vitro antimicrobial potential of Aegiphila sellowiana Cham., Lamiaceae, popularly known as "tamanqueira". This species is an arboreous (or sometimes arbustive) species, which naturally occurs in the tropical and subtropical regions of America, mainly in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens

Ferreira¹,

Carvalho²,

Turatti³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Atividade antimicrobiana de Aegiphila sellowiana Cham., Lamiaceae, contra patógenos orais". A atividade antimicrobiana de Aegiphila sellowiana Cham., Lamiaceae, contra patógenos da cavidade bucal foi avaliada empregando-se o método de microdiluição em caldo, segundo o protocolo CLSI M7-A7, utilizando-se clorexidina como controle positivo. O extrato etanólico bruto das partes aéreas de A. sellowiana, obtido por maceração, exibiu atividade contra os microrganismos testados neste trabalho, entretanto, os valores de CIM (concentração inibitória mínima) aumentaram após a partição com n-hexano, diclorometano e acetato de etila. Entre as frações testadas, a fração n-hexânica foi a mais efetiva contra os patógenos bucais avaliados, com valores de CIM entre 140 e 350 μg/mL -1 . Dados obtidos por CG-EM revelaram que ésteres de ácidos graxos, esteróides e hidrocarbonetos sesquiterpênicos alifáticos são os constituintes majoritários desta fração. Embora esses compostos possam ser os responsáveis pela atividade da fração n-hexânica, outros constituintes químicos presentes nas frações em diclorometano, acetato de etila e hidroalcoólica podem potencializar suas atividades no extrato bruto.Unitermos: Aegiphila sellowiana, antividade antimicrobiana, CG-EM, patógenos orais, Lamiaceae. ABSTRACT:The antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens is reported. The Minimal Inhibitory Concentrations (MICs) for inhibiting the microorganisms growth were determined using the broth microdilution method from the CLSI M7-A7 protocol. Chlorhexidine was used as the positive control. The ethanol crude extract of the aerial parts of A. sellowiana exhibited activity against the microorganisms tested in this work; however, the activity decreased after partition with n-hexane, dichloromethane, and ethyl acetate. Among the tested fractions, the n-hexane fraction was found to be the most effective against the evaluated oral pathogens. GC-MS analysis of this latter fraction revealed that fatty acids esters, steroids, and aliphatic sesquiterpene hydrocarbons are its major constituents. These compounds may be responsible for the activity of the n-hexane fraction, but other chemical constituents of the dichloromethane, ethyl acetate, and hydroalcoholic fraction may potentialize their activities in the crude extract.

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Antimicrobial Activities of Malaysian Plant Species

Cited by 58 publications

References 7 publications

Lipoxygenase inhibiting activity of some Malaysian plants

Lipoxygenase inhibiting activity of some Malaysian plants

Syntheses of Enaminone-Based Heterocyclic Compounds and Study their Biological Activity

Antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens

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