Antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens

Ferreira, Marcele A.; Carvalho, Tiago; Turatti, Izabel Cristina Casanova; Furtado, Niege Araçari Jacometti Cardoso; Martins, Carlos Henrique Gomes; Lopes, Norberto Peporine; Cunha, Wilson Roberto; Crotti, Antônio Eduardo Miller

doi:10.1590/s0102-695x2010000200018

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…To the best of our knowledge, only its antioxidant, larvicidal, and fungicidal potentials have been reported (Lopes & Ritter, 2009;Martinez et al, 2009;Gutierrez et al, 2006). Thus, as a part of our ongoing project on the prospection of biologically active natural products (Keles et al, 2011;Melo et al, 2011;Peixoto et al, 2011;Ferreira et al, 2010), this paper will report the extraction of the essential oil from T. erecta leaves as well as on the investigation of its in vitro schistosomicidal activity against Schistosoma mansoni worms.…”

Section: Introductionmentioning

confidence: 99%

In vitro schistosomicidal effects of the essential oil of Tagetes erecta

Tonuci¹,

Melo²,

Dias³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The in vitro schistosomicidal effects of the essential oil obtained from Tagetes erecta L. Asteraceae, leaves (TE-EO) collected in Brazil against Schistosoma mansoni worms are reported in this paper. The oil caused a significant decrease in the motor activity at 50 μg/mL as minimal concentration after 24 h. This oil also caused death of all the parasites and the separation of coupled pairs into individual male and female at 100 μg/mL after 24 h. The viability of adult worm groups treated with the TE-EO at 100 μg/mL was similar to that of groups treated with praziquantel (positive control). In addition, the oil promoted the inhibition of eggs development at all the tested concentrations. These data indicate that the TE-EO could be considered as a promising source for the development of new schistosomicidal agents.

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Section: Introductionmentioning

confidence: 99%

In vitro schistosomicidal effects of the essential oil of Tagetes erecta

Tonuci¹,

Melo²,

Dias³

et al. 2012

Rev. bras. farmacogn.

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“…This aromatic plant is cultivated for a number of different culinary purposes, having been used in the medicinal folk for the treatment of gonorrhea, dysentery, syphilis, abdominal pain, and asthma (Usia et al 2005). As part of our ongoing project on the prospection of bioactive natural products (Peixoto et al 2011;Keles et al 2011;Cunha et al 2009;Ferreira et al 2010) and essential oils (Melo et al 2011;Caixeta et al 2011), and considering the recent reports on the antiparasitic activity of crude extracts and isolated compounds from Piper species (Al-Adhorey et al 2010; Moraes et al 2011), in this paper, we investigate the in vitro effects of the essential oil from the fruits of P. cubeba against cercariae, schistossomula, and adult S. mansoni worms.…”

Section: Introductionmentioning

confidence: 99%

In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni

et al. 2011

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In this paper, cercariae, schistosomula, and adult Schistosoma mansoni worms were incubated in vitro with the essential oil of Piper cubeba (PC-EO) at concentrations from 12.5 to 200 μg/mL, and the viability was evaluated using an inverted microscopy. The effects of PC-EO at 100 and 200 μg/mL on the stages of S. mansoni were similar to those of the positive control (PZQ at 12.5 μg/mL), with total absence of mobility after 120 h. However, at concentrations from 12.5 to 50 μg/mL, PC-EO caused a reduction in the viability of cercariae and schistosomula when compared with the negative control groups (RPMI 1640 or dechlorinated water) or (RPMI 1640 + 0.1% DMSO or dechlorinated water + 0.1% DMSO). On the other hand, adult S. mansoni worms remained normally active when incubated with PC-EO at concentrations of 12.5 and 25 μg/mL, and their viabilities were similar to those of the negative control groups. In addition, at concentrations ranging from 50 to 200 μg/mL, separation of all the coupled adult worms was observed after 24 h of incubation, which is related to the fact of the reduction in egg production at this concentration. The main chemical constituents of PC-EO were identified by gas chromatography-mass spectrometry as being sabinene (19.99%), eucalyptol (11.87%), 4-terpineol (6.36%), β-pinene (5.81%), camphor (5.61%), and δ-3-carene (5.34%). The cytotoxicity of the PC-EO was determined, and a significant cytotoxicity was only obtained in the concentration of 200 μg/mL after 24 h treatment. The results suggest that PC-EO possesses an effect against cercariae, schistosomula, and adult worms of the S. mansoni.

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“…However, this major compound identified in the essential oil of S. phalerata is also present in the hexane-rich fraction of another species (Lacistema pubescens) that presented action against Leishmania amazonensis promastigote and amastigote forms . Therefore, it appears that phytol is an important molecule in antileishmanial activity, but the individual action of this compound seems insufficient, since it is also present in the essential oil of the dry season in high concentrations, and yet did not present any biological activity.…”

Section: Resultsmentioning

confidence: 97%

Chemical Constituents and Antileishmanial and Antibacterial Activities of Essential Oils from Scheelea phalerata

et al. 2020

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Scheelea phalerata Mart. ex Spreng (Arecaceae) is a palm tree found in the Brazilian cerrado. There are no topics related to volatile oils from S. phalerata leaves in the literature. This work determines its chemical composition and evaluates the biological activity under two different seasonal conditions (dry and rainy seasons). The dry essential oil yield was 0.034 ± 0.001% and the rainy essential oil yield was 0.011 ± 0.003%. Both essential oils presented different qualitative and quantitative compositions (99.4 and 98.5%). The main constituents of the dry essential oil were phytol (36.7%), nonadecane (9.7%), linolenic acid (9.1%), (Z)-hex-3-en-1-ol (4.2%), and squalene (4.0%). The main constituents of the rainy essential oil were phytol (26.1%), palmitic acid (18.7%), hexan-1-ol (15.6%), (Z)-hex-3-en-1-ol (9.7%), and oleic acid (4.0%). The antileishmanial activity against promastigotes of Leishmania amazonensis was observed only for the rainy season essential oil (IC 50 value of 165.05 ± 33.26 μg mL −1 ). A molecular docking study showed that alcohols exert a paramount efficacy and that the action of some essential oil compounds may be similar to that of amphotericin B. Still, only the essential oil from the dry season showed moderate antibacterial activity against S. sanguinis (MICs 200−400 μg mL −1 ). The cytotoxicity against Vero cells was identical (>512) for both essential oils. The novel data here for both chemical characterization and biological activity, in particular, evidence that the action of these compounds is similar to that of amphotericin B, provide valuable information to the drug-discovery field.

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Antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens

Cited by 13 publications

References 18 publications

In vitro schistosomicidal effects of the essential oil of Tagetes erecta

In vitro schistosomicidal effects of the essential oil of Tagetes erecta

In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni

Chemical Constituents and Antileishmanial and Antibacterial Activities of Essential Oils from Scheelea phalerata

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