Lipoxygenase inhibiting activity of some Malaysian plants

Chung, Lip Yong; Soo, Wei Kwan; Chan, Kit Yee; Mustafa, Mohd Rais; Goh, S. H.; Imiyabir, Zamrie

doi:10.3109/13880200903008724

Cited by 37 publications

(20 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inhibitory activity toward 15-lipoxygenase was measured in accordance with Chung et al [13]. Basic samples containing sea buckthorn extract and enzymes were incubated at 37 • C. Then, linoleic acid was added and incubation continued for 20 min.…”

Section: Analysis Of Fatty Acidsmentioning

confidence: 99%

“…The lipoxygenase pathway, including lipoxygenase 5-LOX, 12-LOX, and 15-LOX, is associated with the production of hydroperoxy fatty acids and leukotrienes. Increased concentrations of these products correlate with the progression of, inter alia, inflammatory bowel disease, asthmatic bronchitis, rheumatoid arthritis, cancers, and cardiovascular diseases [13].Therefore, it was assumed that the results will allow the identification of significant differences in the pro-health potential and composition of the studied sea buckthorn cultivars for further use in the design of innovative functional products, nutraceuticals, and cosmeceuticals. Additionally, this study should indicate cultivars with the highest biological potential for further use in planning and expanding cultivations.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Anti-Oxidant and Anti-Enzymatic Activities of Sea Buckthorn (Hippophaë rhamnoides L.) Fruits Modulated by Chemical Components

et al. 2019

View full text Add to dashboard Cite

The aim of this study was to analyze in vitro biological activities as anti-oxidant, anti-α-amylase, anti-α-glucosidase, anti-lipase, and anti-lipoxygenase activity, relative to bioactive components (phenolic acids, flavonols, xanthophylls, carotenes, esterified carotenoids, tocopherols, tocotrienols, and fatty acids) and the basic chemical composition (sugars, organic acid, dry matter, soluble solid, pH, titratable acidity, ash, pectins, and vitamin C) of Hippophaë rhamnoides berries. Six sea buckthorn cultivars commonly grown in Poland were analyzed including Aromatnaja, Botaniczeskaja-Lubitelskaja, Józef, Luczistaja, Moskwiczka, and Podarok Sadu. Berries contained 1.34–2.87 g of sugars and 0.96–4.22 g of organic acids in 100 g fresh weight, 468.60–901.11 mg of phenolic compounds, and 46.61–508.57 mg of carotenoids in 100 g dry mass. The fatty acid profile was established: palmitic > palmitoleic > oleic and linoleic > stearic and linolenic acids. The highest anti-oxidant (34.68 mmol Trolox/100 g dry mass) and anti-α-amylase potential (IC50 = 26.83 mg/mL) was determined in Aromatnaja, anti-α-glucosidase in Botaniczeskaja-Lubitelskaja (IC50 = 41.78 mg/mL), anti-lipase in Moskwiczka and Aromatnaja (average IC50 = 4.37 mg/mL), and anti-lipoxygenase in Aromatnaja and Podarok Sadu fruits (100% inhibition). The studied sea buckthorn berries may be a raw material for the development of functional foods and nutraceutical products rich in compounds with high biological activity.

show abstract

Section: Analysis Of Fatty Acidsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Anti-Oxidant and Anti-Enzymatic Activities of Sea Buckthorn (Hippophaë rhamnoides L.) Fruits Modulated by Chemical Components

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Thus, the antilipoxygenase activity of the extract can be exploited to combat a range of inflammation-related diseases. In a previous study, 160 Malaysian plant extracts were screened for lipoxygenase inhibiting effects at 100 µg/mL; those with more than 70% inhibition were classified as highly active against lipoxygenase, those showing 41-70% inhibition as having moderate activity, and those with 0-40% as having low activity [80]. Accordingly, A. malaccensis leaf extract activity, with 65.56% ± 2.75% inhibition of lipoxygenase at a dose of 100 µg/mL, suggests that the extract exhibits potential moderate antilipoxygenase activity in a concentration-dependent manner.…”

Section: The Antilipoxygenase Assaymentioning

confidence: 99%

Metabolite Profiling of Aquilaria malaccensis Leaf Extract Using Liquid Chromatography-Q-TOF-Mass Spectrometry and Investigation of Its Potential Antilipoxygenase Activity In-Vitro

et al. 2020

View full text Add to dashboard Cite

The Aquilaria malaccensis species of the genus Aquilaria is an abundant source of agarwood resin and many bioactive phytochemicals. Recent data regarding the chemical constituents and biological activities of Aquilaria leaves led us to attempt to qualitatively profile the metabolites of Aquilaria malaccensis leaves from a healthy, noninoculated tree through phytochemical screening, GC-MS, and LC/Q-TOF-MS. The present work is also the first to report the antilipoxygenase activity of A. malaccensis leaves from healthy noninoculated tree and investigate its toxicity on oral mucosal cells. A total of 53 compounds were tentatively identified in the extract, some of which have been described in literature as exhibiting anti-inflammatory activity. A number of compounds were identified for the first time in the extract of A. malaccensis leaf, including quercetin, quercetin-O-hexoside, kaempferol-O-dirhamnoside, isorhamnetin-O-hexoside, syringetin-O-hexoside, myricetin, tetrahydroxyflavanone, hesperetin, sissotrin, and lupeol. The antilipoxygenase assay was used to determine the lipoxygenase (LOX) inhibitory potential of the extract, while a WST-1 assay was conducted to investigate the effect of the extract on oral epithelial cells (OEC). The extract implied moderate anti-LOX activity with IC50 value of 71.6 µg/mL. Meanwhile, the cell viability of OEC ranged between 92.55% (10 µg/mL)–76.06% ± (100 µg/mL) upon treatment, indicating some potential toxicity risks. The results attained encourage future studies of the isolation of bioactive compounds from Aquilaria malaccensis leaves, as well as further investigation on the anti-inflammatory mechanisms and toxicity associated with their use.

show abstract

“…In a screening study for lipoxygenase (LOX) inhibitory activities of some Malaysian plants, the bark of C. polyandrus was found to be one of the most active plant extracts showing strong (71 – 100%) inhibitory activity. In the study, the flowers of C. macranthus , the bark of C. pentandrus , and the leaves of C. polyandrus exhibited moderate activities (41 – 70% inhibition), while the leaves of C. macranthus showed weak (21 – 40% inhibition) activity . Further, the CH 2 Cl 2 extract of C. polyandrus leaves was studied to isolate LOX and cyclooxygenase (COX) inhibitory compounds thorough bioactivity‐guided fractionation.…”

Section: Biological Activitiesmentioning

confidence: 99%

Advances in Chemistry and Bioactivity of the Genus Chisocheton Blume

Shilpi

Saha

Chong

et al. 2016

Chemistry & Biodiversity

View full text Add to dashboard Cite

Chisocheton is one of the genera of the family Meliaceae and consists of ca. 53 species; the distribution of most of those are confined to the Indo-Malay region. Species of broader geographic distribution have undergone extensive phytochemical investigations. Previous phytochemical investigations of this genus resulted in the isolation of mainly limonoids, apotirucallane, tirucallane, and dammarane triterpenes. Reported bioactivities of the isolated compounds include cytotoxic, anti-inflammatory, antifungal, antimalarial, antimycobacterial, antifeedant, and lipid droplet inhibitory activities. Aside from chemistry and biological activities, this review also deals briefly with botany, distribution, and uses of various species of this genus.

show abstract

Lipoxygenase inhibiting activity of some Malaysian plants

Cited by 37 publications

References 62 publications

Anti-Oxidant and Anti-Enzymatic Activities of Sea Buckthorn (Hippophaë rhamnoides L.) Fruits Modulated by Chemical Components

Anti-Oxidant and Anti-Enzymatic Activities of Sea Buckthorn (Hippophaë rhamnoides L.) Fruits Modulated by Chemical Components

Metabolite Profiling of Aquilaria malaccensis Leaf Extract Using Liquid Chromatography-Q-TOF-Mass Spectrometry and Investigation of Its Potential Antilipoxygenase Activity In-Vitro

Advances in Chemistry and Bioactivity of the Genus Chisocheton Blume

Contact Info

Product

Resources

About