Antiinflammatory and Antimicrobial Activities of Mitracarpus scaber Extracts

Ekpendu, T. O.; Akah, P. A.; Adesomoju, Akinbo A.; Okogun, Joseph I.

doi:10.3109/13880209409082992

Cited by 60 publications

(49 citation statements)

References 3 publications

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“…9,11,13 Considering the decreasing of number of Candida in the experimental tubes while the concentrations increased, it was found that the extracts act in a dose-effect relationship. MIC values (Figure 1) of crude extracts X Aq and X 0 indicated that X 0 extract was respectively 8 and 4 times more active than X Aq , but 4 and 8 times less active than X 11 on C. parapsilosis and C. guilliermondii.…”

Section: Resultsmentioning

confidence: 99%

“…This plant has been the subject of several studies including the study of antimicrobial; antifungal, antibacterial activity, anti-inflammatory, antioxidant activities and bio-tolerance. [6][7][8][9][10][11][12] In addition, work on this plant led to isolation of secondary metabolites, some of them of therapeutic interest and even extracts of this plant have been formulated in ointments, and syrups. 6,[13][14][15] Antifungal activity has been evaluated on C. albicans, C. glabrata and C. tropicalis in 2009 and 2010.…”

Section: Introductionmentioning

confidence: 99%

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Antifungal potential of improved crude extracts of Mitracarpus scaber (Zucc) against Candida guilliermondii and Candida parapsilosis

Kporou¹,

Coulibaly

Ackah³

et al. 2017

PBE

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Objective: The present study was undertaken to evaluate antifungal potential of improved crude extracts of Mitracarpus scaber Zucc., an ivorian traditional medicinal plant against two species of clinical yeast isolates: Candida parapsilosis and Candida guilliermondii. Methods:For evaluation of antifungal activity, double dilution method in slope tubes was used. Crude extracts of M. scaber were prepared by extracting with a blender in aqueous and hydroalcohol. In first; Aqueous (X Aq ) and Hydroalcoholic (X 0 ) extracts were evaluated, and secondary the crude extract X 0 was improved by partition in mixture of aqueous and hexanic solvent 50:50 v/v. Each dried phase was also examined. A phytochemical screening has been performed on most active extracts. Results:In vitro antifungal activity showed that crude extract X 0 was the most active with MIC = 6.25 mg/ml. Among the extracts obtained by partition from extract X 0 , extract X 11 (Hexanic phase) was the better with lowest antifungal parameters MIC and MFC range between 1.562 mg/ml and 0.781 mg/ml and IC 50 range between 0.73 mg/ml to 0.598 mg/ml. In addition, the most active extract contained only terpens and steroids.Conclusions: Antifungal activity of M. scaber was improved by partition of an hydroalcoholic extract (X 0 ) in mixture hexane-water 50:50 v/v. Hexanic phase (X 11 ) was more active against C. parapsilosis and C. guilliermondii.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antifungal potential of improved crude extracts of Mitracarpus scaber (Zucc) against Candida guilliermondii and Candida parapsilosis

Kporou¹,

Coulibaly

Ackah³

et al. 2017

PBE

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show abstract

“…Thirty minutes later, diazepam 25 mg/kg was administered intraperitoneally to each mouse. The time taken to lose a righting reflex indicated the onset of sleep, while the time between the loss and recovery of the righting reflex for each mouse was taken as the duration of sleep (Rakotonirina et al, 2001). …”

Section: Diazepam Induced Sleep In Micementioning

confidence: 99%

“…Previous studies revealed that the plant contains biologically active substances such as fatty acids, terpenes, flavonoids and other phenolic compounds with potential hepatoprotective, larvicidal, antifungal, antimicrobial, antinociceptive and antiinflammatory activities (Ekpendu et al, 1994;Germano et al, 1999;Bisignano et al, 2000;Kprou et al, 2010;Makambila-Koebemba et al, 2011;Abdullahi et al, 2011). Furthermore, the pharmacognostic properties of the plant have been studied (Jegede et al, 2005;Abere et al, 2007) and some constituents of the volatile oil isolated and characterized (Ekpendu et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Sedative properties of <i>Mitracarpus villosus</i> leaves in mice

John-Africa¹,

Danjuma²,

Anuka³

et al. 2015

Int. J. Bio. Chem. Sci

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The leaves of Mitracarpus villosus (Sw.) DC. (Rubiaceae) have several therapeutic applications in the West African folk medicine for the management of a plethora of stress-related diseases including headaches. This study was designed to evaluate the sedative properties of the ethylacetate extract of Mitracarpus villosus on open field (OFT), diazepam-induced sleep, staircase climbing, head-dips in the hole-board test and rota rod test in mice. Graded doses (100 -400 mg/kg) of the extract significantly and dose-dependently prolonged the duration of diazepam-induced sleep (P<0.05), decreased the number of squares crossed in the OFT (P<0.0001), decreased number of head-dips in the hole-board test (P<0.05) and reduced steps climbing (P<0.05) in mice.The extract at the doses tested had no effect on motor coordination as observed in the rota-rod treadmill assay in mice. Our results revealed that the ethylacetate extract of Mitracarpus villosus leaves may contain psychoactive principles that are sedative in nature, thus supporting further development of the psychoactive components of this plant for management of stress-related diseases.

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“…Rat hind paw oedema was used as a model of acute inflammation. Rat hind paw oedema was induced by intra-plantar injection of fresh egg albumin (0.5 mL/ kg), a cheap phlogistic agent (Ekpendu et al, 1994;Muko and Ohiri, 2000). The linear diameter of the injected paw was assessed for 3 h at 30 min intervals following administration of the phlogistic agent.…”

Section: Animalsmentioning

confidence: 99%

Analgesic and antiinflammatory effects of mollic acid glucoside, a 1α‐hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf

Ojewole

2007

Phytotherapy Research

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Antiinflammatory and Antimicrobial Activities of Mitracarpus scaber Extracts

Cited by 60 publications

References 3 publications

Antifungal potential of improved crude extracts of Mitracarpus scaber (Zucc) against Candida guilliermondii and Candida parapsilosis

Antifungal potential of improved crude extracts of Mitracarpus scaber (Zucc) against Candida guilliermondii and Candida parapsilosis

Sedative properties of <i>Mitracarpus villosus</i> leaves in mice

Analgesic and antiinflammatory effects of mollic acid glucoside, a 1α‐hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf

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