Sedative properties of &lt;i&gt;Mitracarpus villosus&lt;/i&gt; leaves in mice

John-Africa, LB; Danjuma, NM; Anuka, JA; Chindo, Ben A.

doi:10.4314/ijbcs.v8i5.18

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…For instance, studies have shown that the leaf extract of M. vilosus using different solvent fractions like methanol, acetone ethanol, n-hexane, and ethyl acetate yielded secondary metabolites like terpenoids, phenols, tannins, cardiac glycosides, and carbohydrates (23,24). John-Africa and colleagues investigated the effect of the sedative properties of M.villosis leaves in mice, and observed the presence of psychoactive substances that are sedative in nature, then concluded that M.villosus leaf can be used as a therapeutic agent in the management of stress-related diseases (25). The crushed leaves of M. villosus have also been shown to be beneficial in the treatment of ulcers, ringworms, eczema, and fresh wounds which could be due to its antibacterial and anti-ulcerative properties (24).…”

Section: Discussionmentioning

confidence: 99%

Elucidation of Phytochemicals in Mitracarpus Vilosus Flower Extract using GC-MS

2022

JBAH

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Mitracarpus villosus which belongs to the family of Rubiaceae is one of the important medicinal plants widely known for its broad spectrum of pharmacological activities and biological uses which includes antioxidant, antimicrobial, anti-inflammatory, anti-cancer, anti-ulcer, and antibacterial activities amongst others. It is used in the treatment of various ailments such as ulcers, and skin-related infections like dermatitis, eczema, psoriasis, and acne. This study elucidated the phytochemical properties of Mitracarpus villosus flower. This was achieved through the methanolic extraction of M. villosus flower, and further phytochemical analysis of the methanol extract such as the tannins, saponins, flavonoids, steroids, terpenoids, and cardiac glucoside contents. Moreso, the use of Gas Chromatography-Mass Spectrophotometry (GC-MS) technique was employed on the methanolic extract to isolate and characterize the different bioactive compounds present and to further validate the qualitative data obtained from the phytochemical analysis. Results obtained exhibited the presence of tannins, saponins, flavonoids, steroids, and cardiac glucoside, with a noticeable absence of terpenoids. Also, the GC-MS analysis showed spectra of 52 bioactive compounds present in the extract with five specific compounds having the highest composition such as oleic acid (14.76%), 9,12-Octadecadienoic acid (11.25%), n-Hexadecanoic acid (10.92%), octadecanoic acid (9.21%), and squalene (8.87%) having the highest composition. The presence of these phytochemicals with their numerous biological activities in the methanolic extract of M. vilosus flower makes it a promising pharmaco-therapeutic agent, and thus should be employed in medicine for the treatment of diseases and also as an active agent in the pharmaceutical and non-pharmaceutical industries.

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Section: Discussionmentioning

confidence: 99%

Elucidation of Phytochemicals in Mitracarpus Vilosus Flower Extract using GC-MS

2022

JBAH

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“…That is when mice were rolled sideways and could not stand upright using all four limbs (Miya et al, 1973). The first parameter was decrease in latency of sleep as shown by Crinum zeylanicum (Tijani et al, 2012a) and Gymnema sylvestre (James et al, 2014). The second parameter assessed was increase in the duration of sleep as seen in Hippocratea Africana (Okokon et al, 2014) and Homalium letestui (Okokon and Davies, 2014) all indicating sedative activity.…”

Section: (Iv) Phenobarbitone Induced Sleeping Time (Pist)mentioning

confidence: 99%

Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review

Abubakar¹,

Haque²

2019

Istanbul J Pharm

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Medicinal plants have been widely used in folklore medicine in the treatment of various diseases such as mental and neurological disorders. Mental disorders like anxiety and depression are very common among Nigerian populace. The purpose of this review was to access and evaluate several articles published on the anxiolytic and sedative properties of medicinal plants in Nigeria and to find out the gaps left for further research and drug development. Eighty-two publications available among Nigerian Universities and Research Institutes between 2008 and 2018 were selected. Seven electronic databases such as Nigerian Plant Database, HerbMed, AGRICOLA, MedlinePlus, PubMed, ScienceDirect, and Springer-Link were thoroughly explored from which 226 relevant articles were obtained using Google Scholar, Hotbot and FreeFullPdf as search engines. A number of studies conducted to test for the anxiolytic and sedative activity of medicinal plants in Nigeria were included. Articles published between 2008 and 2018 were selected. The studies were conducted in Nigeria. Research carried out before 2008 was not selected. All publications with authorship outside Nigeria were excluded. Several medicinal plants on which experiments were conducted were reported to have anxiolytic and or sedative properties in Nigeria. Several medicinal plants have shown promise as anxiolytic and sedative agents in laboratory animals' studies. The majority of these plants were used traditionally in the past to treat anxiety in Nigeria. Further research on the efficacy and safety of these medicinal plants could yield a more cost effective and perhaps safer alternative in the treatment of anxiety among Nigerians. Cite this article as: Abubakar AR, Haque M (2019). Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review. Istanbul J Pharm 49 (2): 92-104.

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“…Secondary metabolites : Various studies have identified the presence of important classes of secondary metabolites in the plant. Flavonoids, tannins, terpenoids, phenols, resins and carbohydrates were detected in M. Villosus according to [25]. Furthermore, Saponin and alkaloid are present in the crude extract of M. villosus according to [26].…”

Section: Phytochemistrymentioning

confidence: 99%

Bioactive chemical compounds and pharmacological prospect of Mitracarpus villosus (Swartz) DC- a review

2017

AJBPR

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Mitracarpus villosus [Swartz] DC formerly known as Mitracarpus scaber (Zuccarini) is an annual herb which is widely used in the West African traditional system of medicine as an antibiotic for the management of several disease conditions. The quantitative and qualitative phytochemical analysis from previous research have revealed that saponins, flavonoids, tannins, phenols, alkaloid, soluble carbohydrate, cyanide, cardiac glycoside, steroid, terpenoid, essential oil and reducing sugar are the major constituents of M. Villosus. However, resins, coumarins and anthraquinones are also present in the plant. Furthermore, stigmasterols, pentalongin, azaanthroquinones, gallic acid, 3,4,5-trimethoxybenzoic acid, 4-methoxyacetophenone, 3,4,5trimethoxyacetophenone, kaempferol-3-O-rutinoside, rutin, psoralen, oleanolic and ursolic acids have been isolated from Mitracarpus villosus. The essential oils of Mitracarpus villosus, is dominated by the long-chain aldehyde pentadecanal and the polyunsaturated fatty acid ester methyl (7Z,10Z,13Z)-hexadecatrienoate, with lesser quantities of 2,3-dimethylnaphthoquinone, and α-pinene. These compounds are reported to possess several biological and pharmacological activities, although the antibiotic potential of Mitracarpus villosus is well known, the chemical compounds detected in the plant possess; antioxidant, antidiabetic, antiviral, anticonvulsant, antiinflammatory, antitumour, antihyperlycemic, antihyperlipidemic, antihypertensive activities to mention a few. The cardiovascular protective effect and ability to ameliorate neurodegenerative disorder have also been reported for some of the compounds. Based on the chemical constituents of the plant, M. villosus is a potential candidate for the management of diseases like cancer, HIV and AIDS, liver disease, cardiovascular diseases and neurodegenerative disorders and other diseases. However, this claim is subject to scientific studies.

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Sedative properties of <i>Mitracarpus villosus</i> leaves in mice

Cited by 8 publications

References 23 publications

Elucidation of Phytochemicals in Mitracarpus Vilosus Flower Extract using GC-MS

Elucidation of Phytochemicals in Mitracarpus Vilosus Flower Extract using GC-MS

Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review

Bioactive chemical compounds and pharmacological prospect of Mitracarpus villosus (Swartz) DC- a review

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